Patents by Inventor Hauke Hennecke

Hauke Hennecke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • L-phenylalanyl-tRNA synthetase mutants, a process for the preparation thereof and the use thereof for the in vivo incorporation of non-proteinogenous amino acids into peptides or proteins
    Patent number: 5536652
    Abstract: L-Phenylalanyl-tRNA synthetase mutants, a process for the preparation thereof and the use thereof for the in vivo incorporation of non-proteinogenous amino acids into peptides or proteins.The invention relates to L-phenylalanyl-tRNA synthetases from microorganisms which, by reason of a modification generated by genetic engineering, have an altered substrate selectivity, and to their preparation and use for the in vivo incorporation of non-proteinogenous amino acids into peptides or proteins.
    Type: Grant
    Filed: August 5, 1994
    Date of Patent: July 16, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hauke Hennecke, Peter Kast
  • L-phenylalanyl-tRNA synthetase mutants, a process for the preparation thereof and the use thereof for the in vivo incorporation of non-proteinogenous amino acids into peptides or proteins
    Patent number: 5370995
    Abstract: L-Phenylalanyl-tRNA synthetase mutants, a process for the preparation thereof and the use thereof for the in vivo incorporation of non-proteinogenous amino acids into peptides or proteins.The invention relates to L-phenylalanyl-tRNA synthetases from microorganisms which, by reason of a modification generated by genetic engineering, have an altered substrate selectivity, and to their preparation and use for the in vivo incorporation of non-proteinogenous amino acids into peptides or proteins.
    Type: Grant
    Filed: January 21, 1992
    Date of Patent: December 6, 1994
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hauke Hennecke, Peter Kast
  • Rhizobial ferredoxin genes
    Patent number: 5059533
    Abstract: Rhizobial ferredoxin genes and proteins are provided. Rhizobial ferredoxins are useful to enhance the nitrogenase systems of rhizobia. Useful rhizobial ferredoxin diagnostic segments are also provided comprising DNA sequences encoding the characteristic ferredoxin cysteine residue patterns. Exemplied rhizobial ferredoxin genes are fixX of Rhizobium trifolii and Rhizobium meliloti Between fixC and nifA, fixY of Rhizobium meliloti down stream from nifB, and frxA of Bradyrhizobium japonicum.
    Type: Grant
    Filed: July 15, 1988
    Date of Patent: October 22, 1991
    Assignee: Lubrizol Genetics, Inc.
    Inventors: John M. Watson, Siiri E. Iismaa, Helmut Reilander, Alfred Puhler, Hauke Hennecke
  • Bradyrhizobium japonicum nodulation regulatory protein and gene
    Patent number: 5023180
    Abstract: Nodulation regulatory genes (nodD genes) of Bradyrhizobium japonicum strains have been isolated and sequenced. Recombinant DNA molecules and vectors containing these regulatory genes are described. These genes, molecules and vectors are useful in the genetic engineering of Rhizobium and Bradyrhizobium strains. A method for selective expression of structural genes in response to the application of chemical factors which induce B. japonicum nod genes which employs these genes is described.
    Type: Grant
    Filed: June 11, 1987
    Date of Patent: June 11, 1991
    Assignee: Lubrizol Genetics, Inc.
    Inventors: Edward R. Appelbaum, Hauke Hennecke, Joseph W. Lamb, Michael Gottfert
  • nifH promoters of Bradyrhizobium
    Patent number: 5008194
    Abstract: The nifH promoter regions of Bradyrhizobium japonicum and Bradyrhizobium sp. (parasponia) have been sequenced and found to be significantly homologous. Recombinant DNA molecules comprising foreign genes under the control of such promoters are provided. Rhizobial species containing such recombinant constructions, either in plasmids or integrated into the genome, are provided. These are especially useful for expressing desired foreign genes within root nodules.
    Type: Grant
    Filed: October 16, 1987
    Date of Patent: April 16, 1991
    Assignee: Lubrizol Genetics, Inc.
    Inventors: Barry G. Rolfe, John Shine, Kieran F. Scott, Hauke Hennecke
  • nifD promoter of Bradyrhizobium
    Patent number: 5001061
    Abstract: The nifD promoter regions of Bradyrhizobium japonicum and Bradyhizobium sp. (Parasponia) have been sequenced and found to be significantly homologous. Recombinant DNA molecules comprising foreign genes under the control of such promoters are provided. Rhizobial species containing such recombinant constructions, either in plasmids or integrated into the genome, are provided. These are especially useful for expressing desired foreign genes within root nodules.
    Type: Grant
    Filed: October 16, 1987
    Date of Patent: March 19, 1991
    Assignee: Lubrizol Genetics, Inc.
    Inventors: Barry G. Rolfe, John Shine, Kieran F. Scott, Hauke Hennecke, Kieran F. Scott