Abstract: The disclosure relates to compounds of Formula I or a pharmaceutically acceptable salt thereof, wherein, m, R1-R5, R5A, and L are defined herein. These compounds are useful in methods for stabilizing a mutant PAH protein or reducing blood phenylalanine concentration in a subject suffering from phenylketonuria. In some embodiments, the mutant PAH protein contains at least one R408W, R261Q, R243Q, Y414C, L48S, A403V, I65T, R241C, L348V, R408Q, or V388M mutation. In other embodiments, the mutant PAH protein contains at least one R408W, Y414C, I65T, F39L, R408Q, L348V, R261Q, A300S, or L48S mutation.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to coordinate node level adaptations. An example apparatus includes an adaptation support determiner to determine if an adaptation in an adaptation message is supported by a first device, an extractor to, in response to the determination that the adaptation in the adaptation message is supported by the first device, calculate a start-time for the first device based on (a) a transit duration of the adaptation message, (b) an execution duration of the adaptation in the adaptation message, and (c) a timestamp of when the second device sent the adaptation message, and an initiate a timer value for the first device and the second device, the timer value being a function of the start-time. The example apparatus further includes an installer to, in response to the timer value satisfying a threshold, execute the adaptation to reduce disruptions in the CPS.

Abstract: Technologies for managing network traffic through heterogeneous fog network segments of a fog network include a fog node deployed in a fog network segment. The fog node is configured to receive a fog frame that includes control instructions. The fog node is further configured to perform a route selection action to identify a preferred target fog node based on the control instructions, perform action(s) based on the control instructions and network characteristic(s) of the fog network segment relative to corresponding network characteristic(s) of the different fog network segment, and generate updated control instructions based on at least one network characteristic of the different fog network segment. Additionally, the fog node is configured to replace the original control instructions of the received fog frame with the updated control instructions and transmit the received fog frame with the updated control instructions to the preferred target fog node. Other embodiments are described and claimed.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to coordinate node level adaptations. An example apparatus includes an adaptation support determiner to determine if an adaptation in an adaptation message is supported by a first device, an extractor to, in response to the determination that the adaptation in the adaptation message is supported by the first device, calculate a start-time for the first device based on (a) a transit duration of the adaptation message, (b) an execution duration of the adaptation in the adaptation message, and (c) a timestamp of when the second device sent the adaptation message, and an initiate a timer value for the first device and the second device, the timer value being a function of the start-time. The example apparatus further includes an installer to, in response to the timer value satisfying a threshold, execute the adaptation to reduce disruptions in the CPS.

Abstract: Technologies for managing network traffic through heterogeneous fog network segments of a fog network include a fog node deployed in a fog network segment. The fog node is configured to receive a fog frame that includes control instructions. The fog node is further configured to perform a route selection action to identify a preferred target fog node based on the control instructions, perform action(s) based on the control instructions and network characteristic(s) of the fog network segment relative to corresponding network characteristic(s) of the different fog network segment, and generate updated control instructions based on at least one network characteristic of the different fog network segment. Additionally, the fog node is configured to replace the original control instructions of the received fog frame with the updated control instructions and transmit the received fog frame with the updated control instructions to the preferred target fog node. Other embodiments are described and claimed.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to coordinate node level adaptations. An example apparatus includes an adaptation support determiner to determine if an adaptation in an adaptation message is supported by a first device, an extractor to, in response to the determination that the adaptation in the adaptation message is supported by the first device, calculate a start-time for the first device based on (a) a transit duration of the adaptation message, (b) an execution duration of the adaptation in the adaptation message, and (c) a timestamp of when the second device sent the adaptation message, and an initiate a timer value for the first device and the second device, the timer value being a function of the start-time. The example apparatus further includes an installer to, in response to the timer value satisfying a threshold, execute the adaptation to reduce disruptions in the CPS.

Abstract: Technologies for managing network traffic through heterogeneous fog network segments of a fog network include a fog node deployed in a fog network segment. The fog node is configured to receive a fog frame that includes control instructions. The fog node is further configured to perform a route selection action to identify a preferred target fog node based on the control instructions, perform action(s) based on the control instructions and network characteristic(s) of the fog network segment relative to corresponding network characteristic(s) of the different fog network segment, and generate updated control instructions based on at least one network characteristic of the different fog network segment. Additionally, the fog node is configured to replace the original control instructions of the received fog frame with the updated control instructions and transmit the received fog frame with the updated control instructions to the preferred target fog node. Other embodiments are described and claimed.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to coordinate node level adaptations. An example apparatus includes an adaptation support determiner to determine if an adaptation in an adaptation message is supported by a first device, an extractor to, in response to the determination that the adaptation in the adaptation message is supported by the first device, calculate a start-time for the first device based on (a) a transit duration of the adaptation message, (b) an execution duration of the adaptation in the adaptation message, and (c) a timestamp of when the second device sent the adaptation message, and an initiate a timer value for the first device and the second device, the timer value being a function of the start-time. The example apparatus further includes an installer to, in response to the timer value satisfying a threshold, execute the adaptation to reduce disruptions in the CPS.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to coordinate node level adaptations. An example apparatus includes an adaptation support determiner to determine if an adaptation in an adaptation message is supported by a first device, an extractor to, in response to the determination that the adaptation in the adaptation message is supported by the first device, calculate a start-time for the first device based on (a) a transit duration of the adaptation message, (b) an execution duration of the adaptation in the adaptation message, and (c) a timestamp of when the second device sent the adaptation message, and an initiate a timer value for the first device and the second device, the timer value being a function of the start-time. The example apparatus further includes an installer to, in response to the timer value satisfying a threshold, execute the adaptation to reduce disruptions in the CPS.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to coordinate node level adaptations. An example apparatus includes an adaptation support determiner to determine if an adaptation in an adaptation message is supported by a first device, an extractor to, in response to the determination that the adaptation in the adaptation message is supported by the first device, calculate a start-time for the first device based on (a) a transit duration of the adaptation message, (b) an execution duration of the adaptation in the adaptation message, and (c) a timestamp of when the second device sent the adaptation message, and an initiate a timer value for the first device and the second device, the timer value being a function of the start-time. The example apparatus further includes an installer to, in response to the timer value satisfying a threshold, execute the adaptation to reduce disruptions in the CPS.

Abstract: Technologies for managing network traffic through heterogeneous fog network segments of a fog network include a fog node deployed in a fog network segment. The fog node is configured to receive a fog frame that includes control instructions. The fog node is further configured to perform a route selection action to identify a preferred target fog node based on the control instructions, perform action(s) based on the control instructions and network characteristic(s) of the fog network segment relative to corresponding network characteristic(s) of the different fog network segment, and generate updated control instructions based on at least one network characteristic of the different fog network segment. Additionally, the fog node is configured to replace the original control instructions of the received fog frame with the updated control instructions and transmit the received fog frame with the updated control instructions to the preferred target fog node. Other embodiments are described and claimed.