Patents by Inventor Hee Kyoon Yoon
Hee Kyoon Yoon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11661406Abstract: A method of preparing an intermediate useful for the synthesis of a diphenylmethane derivative that can be used as an SGLT inhibitor is described. A method of synthesizing a compound of Formula 7 can address problems of existing synthesis processes requiring the synthesis of the Grignard reagent and management of related substances. In addition, the method can minimize the generation of related substances, and thus does not require reprocessing of reaction products, thereby simplifying the process. Accordingly, the production yield of a diphenylmethane derivative can be maximized.Type: GrantFiled: August 9, 2019Date of Patent: May 30, 2023Assignee: DAEWOONG PHARMACEUTICAL CO., LTD.Inventors: Qing Ri Li, Hee Kyoon Yoon
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Publication number: 20230096670Abstract: An intermediate useful for the synthesis of an SGLT inhibitor and a method for preparing an SGLT inhibitor are provided. By employing an intermediate having Chemical Formula 5, the difficulty of purification with existing processes can be solved, the quality requirements for related substances can be achieved with only one purification step, and the quality control problem in each step can be solved by performing several steps in situ. A method for synthesizing a compound of Chemical Formula 1 by using a compound of Chemical Formula 5 enables purification in an earlier step, thereby solving the problems of existing synthesis processes, in which the quality requirements for related substances were difficult to control step-by-step due to a continuous process, thereby minimizing the amount of related substances in the final product. In addition, the yield of a diphenylmethane derivative according to Chemical Formula 1 is increased.Type: ApplicationFiled: February 26, 2021Publication date: March 30, 2023Inventors: Youn Jung YOON, Hee Kyoon YOON
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Publication number: 20210292291Abstract: A method of preparing an intermediate useful for the synthesis of a diphenylmethane derivative that can be used as an SGLT inhibitor is described. A method of synthesizing a compound of Formula 7 can address problems of existing synthesis processes requiring the synthesis of the Grignard reagent and management of related substances. In addition, the method can minimize the generation of related substances, and thus does not require reprocessing of reaction products, thereby simplifying the process. Accordingly, the production yield of a diphenylmethane derivative can be maximized.Type: ApplicationFiled: August 9, 2019Publication date: September 23, 2021Inventors: Qing Ri LI, Hee Kyoon YOON
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Patent number: 10889574Abstract: The present invention relates to an improved method for producing a diphenylmethane derivative which is effective as a sodium-dependent glucose cotransporter (SGLT) inhibitor, the method being carried out by means of a convergent synthesis method in which each major group is separately synthesized and then coupled. As such, in comparison to a linear synthesis method disclosed in existing documents, the synthesis pathway is compact and yield can be increased, and risk factors inherent in the linear synthesis pathway can be reduced. Furthermore, the crystal form of the compound produced according to the method has superb physicochemical characteristics, and thus can be effectively utilized in fields such as pharmaceutical manufacturing.Type: GrantFiled: August 30, 2019Date of Patent: January 12, 2021Assignees: DAEWOONG PHARMACEUTICAL CO., LTD., GREEN CROSS CORPORATIONInventors: Hee-kyoon Yoon, Se-Hwan Park, Ji-sung Yoon, Soongyu Choi, Hee Jeong Seo, Eun-Jung Park, Younggyu Kong, Kwang-Seop Song, Min Ju Kim, So Ok Park
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Patent number: 10640496Abstract: The present invention relates to an improved method for producing a diphenylmethane derivative which is effective as a sodium-dependent glucose cotransporter (SGLT) inhibitor, the method being carried out by means of a convergent synthesis method in which each major group is separately synthesized and then coupled. As such, in comparison to a linear synthesis method disclosed in existing documents, the synthesis pathway is compact and yield can be increased, and risk factors inherent in the linear synthesis pathway can be reduced. Furthermore, the crystal form of the compound produced according to the method has superb physicochemical characteristics, and thus can be effectively utilized in fields such as pharmaceutical manufacturing.Type: GrantFiled: June 15, 2017Date of Patent: May 5, 2020Assignees: DAEWOONG PHARMACEUTICAL CO., LTD., GREEN CROSS CORPORATIONInventors: Hee-kyoon Yoon, Se-Hwan Park, Ji-sung Yoon, Soongyu Choi, Hee Jeong Seo, Eun-Jung Park, Younggyu Kong, Kwang-Seop Song, Min Ju Kim, So Ok Park
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Publication number: 20190382390Abstract: The present invention relates to an improved method for producing a diphenylmethane derivative which is effective as a sodium-dependent glucose cotransporter (SGLT) inhibitor, the method being carried out by means of a convergent synthesis method in which each major group is separately synthesized and then coupled. As such, in comparison to a linear synthesis method disclosed in existing documents, the synthesis pathway is compact and yield can be increased, and risk factors inherent in the linear synthesis pathway can be reduced. Furthermore, the crystal form of the compound produced according to the method has superb physicochemical characteristics, and thus can be effectively utilized in fields such as pharmaceutical manufacturing.Type: ApplicationFiled: August 30, 2019Publication date: December 19, 2019Applicants: DAEWOONG PHARMACEUTICAL CO., LTD., GREEN CROSS CORPORATIONInventors: Hee-kyoon YOON, Se-Hwan PARK, Ji-sung YOON, Soongyu CHOI, Hee Jeong SEO, Eun-Jung PARK, Younggyu KONG, Kwang-Seop SONG, Min Ju KIM, So Ok PARK
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Publication number: 20190169174Abstract: The present invention relates to an improved method for producing a diphenylmethane derivative which is effective as a sodium-dependent glucose cotransporter (SGLT) inhibitor, the method being carried out by means of a convergent synthesis method in which each major group is separately synthesized and then coupled. As such, in comparison to a linear synthesis method disclosed in existing documents, the synthesis pathway is compact and yield can be increased, and risk factors inherent in the linear synthesis pathway can be reduced. Furthermore, the crystal form of the compound produced according to the method has superb physicochemical characteristics, and thus can be effectively utilized in fields such as pharmaceutical manufacturing.Type: ApplicationFiled: June 15, 2017Publication date: June 6, 2019Applicants: DAEWOONG PHARMACEUTICAL CO., LTD., GREEN CROSS CORPORATIONInventors: Hee-kyoon YOON, Se-Hwan PARK, Ji-Sung YOON, Soongyu CHOI, Hee Jeong SEO, Eun-Jung PARK, Younggyu KONG, Kwang-Seop SONG, Min Ju KIM, So Ok PARK
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Publication number: 20170224660Abstract: The present invention provides a process for preparing an ertapenem-containing lyophilized formulation, comprising the use of hydroxypropyl p-cyclodextrin as both a cryoprotective agent and a stabilizing agent.Type: ApplicationFiled: July 28, 2015Publication date: August 10, 2017Applicant: DAEWOONG PHARMACEUTICAL CO., LTD.Inventors: Bong-Yong LEE, Hee-Kyoon YOON, Wol-Young KIM, Jeong-Taek SHIN
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Patent number: 9717708Abstract: The present invention provides a process for preparing an ertapenem-containing lyophilized formulation, comprising the use of hydroxypropyl ?-cyclodextrin as both a cryoprotective agent and a stabilizing agent.Type: GrantFiled: July 28, 2015Date of Patent: August 1, 2017Assignee: DAEWOONG PHARMACEUTICAL CO., LTD.Inventors: Bong-Yong Lee, Hee-Kyoon Yoon, Wol-Young Kim, Jeong-Taek Shin
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Patent number: 9328115Abstract: Provided is a process for the preparation of meropenem trihydrate in high purity and high yield, including using a dry methanol solvate of meropenem, which can remarkably reduce the amount of residual solvents in the resulting product, thereby obtain meropenem trihydrate in high purity.Type: GrantFiled: November 21, 2013Date of Patent: May 3, 2016Assignee: DAEWOONG PHARMACEUTICAL CO., LTD.Inventors: Soo-Jin Choi, Byung-Goo Lee, Hee-Kyoon Yoon, Sung-Woo Park, Sun-Ah Jun, Kyung-Ho Lee, Byung-Jo Lim
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Patent number: 9233963Abstract: The present invention relates to an improved method for synthesizing meropenem trihydrate[(1R,5S,6S)-2-[((2?S,4?S)-2?-dimethylaminocarbozyl)pyrrolidin-4?-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid, trihydrate], which is a novel carbapenem antibiotic.Type: GrantFiled: March 11, 2010Date of Patent: January 12, 2016Assignees: DAEWOONG PHARMACEUTICAL CO., LTD., DAEWOONG BIO, INC.Inventors: Yoon Seok Song, Sung Woo Park, Yeon Jung Yoon, Hee Kyoon Yoon, Seong Cheol Moon, Byung Goo Lee, Soo Jin Choi, Sun Ah Jun
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Publication number: 20150353554Abstract: Provided is a process for the preparation of meropenem trihydrate in high purity and high yield, including using a dry methanol solvate of meropenem, which can remarkably reduce the amount of residual solvents in the resulting product, thereby obtain meropenem trihydrate in high purity.Type: ApplicationFiled: November 21, 2013Publication date: December 10, 2015Applicant: DAEWOONG PHARMACEUTICAL CO., LTD.Inventors: Soo-Jin CHOI, Byung-Goo LEE, Hee-Kyoon YOON, Sung-Woo PARK, Sun-Ah JUN, Kyung-Ho LEE, Byung-Jo LIM
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Patent number: 9040572Abstract: This invention relates to a method of preparing a benzoimidazole derivative at high purity and high yield so as to enable the production of the benzoimidazole derivative compound as an antagonist against a vanilloid reactor-1, and particularly to a method of preparing a benzoimidazole derivative at high purity and high yield, wherein the benzoimidazole derivative is synthesized using a novel intermediate, namely, benzaldehyde, and thereby the preparation process is simple so that it can be applied to production.Type: GrantFiled: September 27, 2011Date of Patent: May 26, 2015Assignee: Daewoong Pharmaceutical Co., Ltd.Inventors: In Woo Kim, Ji Duck Kim, Hong Chul Yoon, Hee Kyoon Yoon, Byung Goo Lee, Joon Hwan Lee, Young Mook Lim, Soo Jin Choi
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Publication number: 20130231477Abstract: This invention relates to a method of preparing a benzoimidazole derivative at high purity and high yield so as to enable the production of the benzoimidazole derivative compound as an antagonist against a vanilloid reactor-1, and particularly to a method of preparing a benzoimidazole derivative at high purity and high yield, wherein the benzoimidazole derivative is synthesized using a novel intermediate, namely, benzaldehyde, and thereby the preparation process is simple so that it can be applied to production.Type: ApplicationFiled: September 27, 2011Publication date: September 5, 2013Applicant: DAEWOONG PHARMACEUTICAL CO., LTD.Inventors: In Woo Kim, Ji Duck Kim, Hong Chul Yoon, Hee Kyoon Yoon, Byung Goo Lee, Joon Hwan Lee, Young Mook Lim, Soo Jin Choi
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Publication number: 20120065392Abstract: The present invention relates to an improved method for synthesizing meropenem trihydrate [(1R,5S,6S)-2-[((2?S,4?S)-2?-dimethylaminocarbozyl)pyrrolidin-4?-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid, trihydrate], which is a novel carbapenem antibiotic.Type: ApplicationFiled: March 11, 2010Publication date: March 15, 2012Applicants: DAEWOONG BIO INC., DAEWOONG PHARMACEUTICAL CO., LTD.Inventors: Yoon Seok Song, Sung Woo Park, Yeon Jung Yoon, Hee Kyoon Yoon, Seong Cheol Moon, Byung Goo Lee, Soo Jin Choi, Sun Ah Jun