Abstract: The present invention relates to a pharmaceutical composition, for treating glioblastoma, comprising a nucleic acid complex as an active ingredient and, more particularly, to a pharmaceutical composition, for preventing or treating glioblastoma, comprising a nucleic acid complex having complementarily bound: a bioactive peptide nucleic acid having a sequence binding to TGF-?2 gene; and a carrier peptide nucleic acid. The nucleic acid complex according to the present invention has excellent cell permeability and intracellular activity and can effectively inhibit the expression of TGF-?2 gene and the hypostatic gene thereof, and thus is useful in preventing or treating glioblastoma.

Abstract: An image encoding/decoding method, device and recording medium based on accumulation of a region of interest of the present disclosure may include partitioning a current image to acquire a region of interest, cumulatively expressing the region of interest in a reference image of the current image and decoding the current image based on a reference image in which the region of interest is cumulatively expressed.

Abstract: Proposed are an unsupported metallic catalyst for a selective ring-opening (SRO) reaction and a method of using the same catalyst, wherein the catalyst contains nickel (Ni), molybdenum (Mo), and tungsten (W).

Abstract: Disclosed are a refrigerator and a method for displaying a user interface on the refrigerator, a user terminal, and a method for performing a function in the user terminal. The refrigerator according to the present disclosure may include: a storage chamber storing food therein; a temperature detection unit configured to detect the internal temperature of the storage chamber; a cooling unit configured to supply cold air to the storage chamber; a camera configured to photograph food in the storage chamber; a communication unit configured to communicate with a user terminal; a display; at least one processor electrically connected to the temperature detection unit, the camera, the cooling unit, and the communication unit; and a memory electrically connected to the at least one processor.

Abstract: The present disclosure provides a novel biphenyl derivative compound or a pharmaceutically acceptable salt thereof. The biphenyl derivative compound or pharmaceutically acceptable salt thereof according to the present disclosure is a compound that increases Nm23-H1/NDPK activity and can inhibit cancer metastasis and growth. Thus, it exhibits excellent effects not only on the prevention, alleviation and treatment of cancer, but also on the suppression of cancer metastasis.

Abstract: The present invention relates to a novel-structured nucleic acid complex having a blood-brain barrier penetration ability and a composition comprising same and, more specifically, to a nucleic acid complex in which a bioactive nucleic acid is complementarily bound to a carrier peptide nucleic acid modified to be generally positively charged, and to a composition for blood-brain barrier penetration comprising same. The nucleic acid complex according to the present invention can penetrate the blood-brain barrier at excellent efficiency, and especially, the conjugation of a drug into the nucleic acid complex increases the blood-brain barrier penetration ability of the drug, and thus is very useful in treatment or diagnosis of diseases.

Abstract: A method for producing CAR-M1 macrophages expressing a chimeric antigen receptor in vitro and in vivo includes using a conjugate of a non-viral gene delivery system and a chimeric antigen receptor gene. The CAR-M1 macrophages are produced in vivo by delivering genes encoding a chimeric antigen receptor and IFN-?, specifically to macrophages in the body, and thus does not require culturing and preparing an in-vitro cellular therapeutic agent, thus reducing the manufacturing costs of therapeutic agents. The CAR-M1 macrophages are a safer therapy since a non-viral vector is used, as compared to the production of CAR-M1 macrophages by gene delivery using a viral vector, and are a novel therapeutic candidate having the advantage of high anticancer efficiency for solid cancers, due to CAR-M1 macrophages in which intrinsic properties of macrophages infiltrating solid cancers and cancer cell phagocytosis are improved.

Abstract: A medical probe sterilizer includes a main body having a sterilizing chamber configured to accommodate a medical probe to be sterilized therein and configured to be opened and closed, a probe holder installed on the main body and configured to hold the medical probe to be located inside the sterilizing chamber, a UV sterilization unit configured to sterilize the medical probe in the sterilizing chamber by using UV light, a plasma sterilization processing unit configured to sterilize the medical probe in the sterilizing chamber by using plasma, and a sealer configured to prevent leakage of the plasma to the outside of the sterilizing chamber.

Abstract: An automatic medical condom supply device includes a condom supply part installed inside a device body to supply, one by one, medical condom modules each of which is wrapped in a wrapper, a condom withdrawal part moving, to the outside of the device body, through an outlet formed in the device body, each of the medical condom modules supplied from the condom supply part, a wrapper removal part removing the wrapper of the medical condom module withdrawn to the outside of the device body by the condom withdrawal part, and a condom holding part installed outside the device body to hold a medical condom discharged through the outlet so that a medical probe is coupled with the medical condom from which the wrapper has been removed.

Abstract: The present disclosure provides a method for delivering a neuroprotective polypeptide to at least a portion of a central nervous system (CNS) of a subject.

Abstract: An apparatus of controlling autonomous driving in a transition demand (TD) process during the autonomous driving and a method thereof are provided. A controller is configured to determine whether there is a section where it is impossible to operate autonomous driving in front of an autonomous driving route of an autonomous vehicle, during autonomous driving of the autonomous vehicle, determines a maximum speed limit while a TD is output, based on a current speed of the autonomous vehicle, outputs the TD before a predetermined distance from the section where it is impossible to operate the autonomous driving, and is configured to control a speed of the autonomous vehicle based on the maximum speed limit. The apparatus enhances a problem in which a TD is initiated from a too long distance to the section where it is impossible to operate the autonomous driving.

Abstract: An autonomous driving control apparatus for a vehicle includes: a processor that demands a user of a vehicle to take a control authority of the vehicle during an autonomous driving control when a current driving condition is in a limit situation during the autonomous driving control, and starts a minimum risk maneuver to disable reactivation of the autonomous driving control when the control authority is not transferred to the user; and a storage to store a set of instructions to be executed by the processor and data for determination and performance by the processor. In particular, the processor automatically flashes an emergency light when the minimum risk maneuver is started, and controls automatic flashing of the emergency light to not be released by the user when the vehicle is not in a stopped state.

Abstract: An autonomous driving control apparatus for a vehicle includes: a processor that determines whether a current driving condition of the vehicle is a limit situation during an autonomous driving control. When the limit situation is determined, the processor demands to transfer a control authority to a user of the vehicle, and if the control authority is not transferred to the user, the processor starts a minimum risk maneuver and controls engagement of an electronic parking brake device when the vehicle is stopped after the minimum risk maneuver ends. The autonomous driving control apparatus further includes a storage configured to store driving condition data of the vehicle and a set of instructions executed by the processor.

Abstract: The present invention relates to a surface treatment method for dental zirconia, including sandblasting the surface of three types of dental zirconia (3Y-TZP, 4Y-PSZ and 5Y-PSZ) with alumina particles, and this method optimizes sandblasting conditions for each type of zirconia and enhances mechanical properties by strengthening residual stress. In addition, a dental article including dental zirconia made by the surface treatment method for zirconia, and suitable protocols for the durable bond between resin cements and high-translucent zirconia are suggested.

Abstract: An autonomous driving control apparatus for a vehicle includes: a processor that demands a user of a vehicle to take a control authority of the vehicle during an autonomous driving control when a current driving condition is in a limit situation during the autonomous driving control, and starts a minimum risk maneuver to disable reactivation of the autonomous driving control when the control authority is not transferred to the user; and a storage to store a set of instructions to be executed by the processor and data for determination and performance by the processor. In particular, the processor automatically flashes an emergency light when the minimum risk maneuver is started, and controls automatic flashing of the emergency light to not be released by the user when the vehicle is not in a stopped state.

Abstract: An autonomous driving control apparatus for a vehicle includes: a processor that determines whether a current driving condition of the vehicle is a limit situation during an autonomous driving control, performs a demand for control authority transition to a user during the autonomous driving control when the current driving condition is the limit situation, and starts a minimum risk maneuver to transmit a signal for disabling reactivation of the autonomous driving control when control authority is not transferred to the user; and a storage to store a set of instructions and driving condition data to be used by the processor. In particular, the processor demands for engagement of an electronic parking brake device when the vehicle is stopped after the minimum risk maneuver ends.

Abstract: A method for controlling autonomous driving in an autonomous vehicle includes detecting an autonomous driving-related critical situation during the autonomous driving, outputting a notification message requesting a control-right handover from an autonomous driving system to a human driver when the autonomous driving-related critical situation is detected, and activating a minimal risk maneuver (MRM) driving mode to deactivate the autonomous driving system when the control-right handover is not successful. In particular, when the minimal risk maneuver (MRM) driving mode is activated, the deactivated state of the autonomous driving system is maintained until an engine-restart of the autonomous vehicle is detected.

Abstract: Provided are a doorbell system and a method of operating the same. The doorbell system includes a doorbell which includes: a camera configured to obtain at least one of an image of a first object in a first region and an image of a second object in a second region closer to the doorbell than the first region; an image processor configured to detect the first object from the image of the first object, and identify the second object from the image of the second object; and an alert generator configured to select and transmit to a user terminal an alert sound or alert sound information corresponding to the identified second object.

Abstract: Provided is a surface treatment method for dental zirconia, which includes sandblasting the surfaces of three types of dental zirconia (3Y-TZP, 4Y-PSZ and 5Y-PSZ) with alumina particles, and when sandblasting conditions are optimized for each type of zirconia, the microstructure destruction of a subsurface layer may be minimized and compressive stress may be reinforced by a phase change, thereby improving mechanical properties, and the penetration of resin cement through microcracks inhibits crack propagation and thus is advantageous in increasing bonding efficiency of dental zirconia. In addition, a dental article including dental zirconia made by the surface treatment method for zirconia, and clinically suitable sandblasting protocols are provided.

Abstract: The present disclosure provides a method for delivering a neuroprotective polypeptide to at least a portion of a central nervous system (CNS) of a subject.