Patents by Inventor Hege Karlsen

Hege Karlsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Contrast agents
    Patent number: 8273325
    Abstract: The present invention provides novel compounds and pharmaceutical compositions containing such compounds, wherein the compounds have affinity for proteoglycans. The compounds comprise an amino acid based core unit linked to positively charged moieties. The compounds further comprise at least one imaging moiety detectable in in vivo imaging making the compounds useful as diagnostic contrast agents for imaging of proteoglycans, such as heparan sulphate proteoglycans.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: September 25, 2012
    Assignee: GE Healthcare AS
    Inventors: Helge Tolleshaug, Alan Cuthbertson, Hege Karlsen
  • Radiofluorination methods
    Patent number: 8216548
    Abstract: The invention relates to conjugates of formula (V) or (VI), their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes.
    Type: Grant
    Filed: December 27, 2007
    Date of Patent: July 10, 2012
    Assignee: GE Healthcare AS
    Inventors: Alan Cuthbertson, Magne Solbakken, Hege Karlsen
  • Methods of radiofluorination of biologically active vectors
    Patent number: 8197793
    Abstract: The invention relates to conjugates of formula (V) or (VI): wherein X is —CO—NH—, —NH—, —O—, —NHCONH—, or —NHCSNH—; their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes.
    Type: Grant
    Filed: March 12, 2004
    Date of Patent: June 12, 2012
    Assignee: GE Healthcare AS
    Inventors: Alan Cuthbertson, Magne Solbakken, Joseph Maduabuchi Arukwe, Hege Karlsen, Matthias Eberhard Glaser
  • CONTRAST AGENTS
    Publication number: 20100111865
    Abstract: The present invention provides novel compounds and pharmaceutical compositions containing such compounds, wherein the compounds have affinity for proteoglycans. The compounds comprise an amino acid based core unit linked to positively charged moieties. The compounds further comprise at least one imaging moiety detectable in in vivo imaging making the compounds useful as diagnostic contrast agents for imaging of proteoglycans, such as heparan sulphate proteoglycans.
    Type: Application
    Filed: December 19, 2007
    Publication date: May 6, 2010
    Applicant: GE HEALTHCARE AS
    Inventors: Helge Tolleshaug, Alan Cuthbertson, Hege Karlsen
  • Methods of radiofluorination of biologically active vectors
    Publication number: 20100068139
    Abstract: The invention relates to conjugates of formula (V) or (VI): wherein X is —CO—NH—, —NH—, —O—, —NHCONH—, or —NHCSNH—; their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes.
    Type: Application
    Filed: March 12, 2004
    Publication date: March 18, 2010
    Inventors: Alan Cuthbertson, Magne Solbakken, Joseph Maduabuchi Arukwe, Hege Karlsen, Matthias Eberhard Glaser
  • RADIOFLUORINATION METHODS
    Publication number: 20100034740
    Abstract: The invention relates to conjugates of formula (V) or (VI), their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes.
    Type: Application
    Filed: December 27, 2007
    Publication date: February 11, 2010
    Inventors: Alan Cuthbertson, Magne Solbakken, Hege Karlsen
  • RADIOFLORINATION METHODS
    Publication number: 20080274052
    Abstract: The present invention relates to methods and reagents for [18F]-fluorination, particularly of peptides. The resultant 18F-labelled compounds are useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET). Thus, a compound of formula 18F-(Linker)-SH, such as a compound of formula (IV), (V), or (VI): may be reacted with an activated peptide as a means for 18F-labelling.
    Type: Application
    Filed: April 7, 2008
    Publication date: November 6, 2008
    Applicant: GE HEALTHCARE LIMITED
    Inventors: Alan Cuthbertson, Magne Solbakken, Joseph Maduabuchi Arukwe, Hege Karlsen
  • Radiolabelled Insulin
    Publication number: 20080213174
    Abstract: The invention relates to in vivo imaging agents, specifically radiolabelled insulin derivatives of formula (III); wherein X is —CO—NH—, —NH—, —O—, —NHCONH—, or —NHCSNH—, and is preferably —CO—NH—, —NH— or —O—; Y is H, alkyl or aryl substituents; R* is a radiolabel moiety suitable for detection by SPECT or PET; and methods for preparing the same as well as their use in in vivo imaging methods.
    Type: Application
    Filed: September 13, 2005
    Publication date: September 4, 2008
    Inventors: Matthias Eberhard Glaser, Frank Brady, Sajinder Kaur Luthra, Alan Cuthbertson, Hege Karlsen
  • Radiofluorination methods
    Patent number: 7368474
    Abstract: The present invention relates to methods and reagents for [18F]-fluorination, particularly of peptides. The resultant 18F-labelled compounds are useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET). Thus, a compound of formula 18F-(Linker)-SH, such as a compound of formula (IV), (V), or (VI): 18F—(CH2CH2O)n—(CH2)m—SH ??(IV) 18F—(CH2)p—SH ??(V) may be reacted with an activated peptide as a means for 18F-labelling.
    Type: Grant
    Filed: March 20, 2003
    Date of Patent: May 6, 2008
    Assignee: GE Healthcare Limited
    Inventors: Alan Cuthbertson, Magne Solbakken, Joseph Maduabuchi Arukwe, Hege Karlsen
  • Radiofluorination methods
    Publication number: 20050142061
    Abstract: The present invention relates to methods and reagents for [18F]-fluorination, particularly of peptides. The resultant 18F-labelled compounds are useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET). Thus, a compound of formula 18F-(Linker)-SH, such as a compound of formula (IV), (V), or (VI): 18F—(CH2CH2O)n—(CH2)m—SH ??(IV) 18F—(CH2)p—SH ??(V) may be reacted with an activated peptide as a means for 18F-labelling.
    Type: Application
    Filed: March 20, 2003
    Publication date: June 30, 2005
    Inventors: Alan Cuthbertson, Magne Solbakken, Joseph Arukwe, Hege Karlsen