Abstract: There is disclosed herein a process for purifying a crude xanthophyll which is characterized by acting a lipase on the crude xanthophyll, which is obtained by extracting algae with a solvent, in the present of water under an acidic condition without adjusting the pH whereupon the contaminating neutral lipids (mono-, di- and triglycerides) are selectively hydrolyzed, subjecting the lipase-treated liquor to oil/water separation and removing free fatty acids from the oil layer fractioned thereby elevating the content of xanthophyll.

Abstract: A simulated moving bed type chromatographic separation apparatus is provided in which a plurality of columns each filled with a hydrophobic adsorbent for reversed-phase liquid chromatography having a relatively low affinity for tocotrienol than that for tocopherol are connected cyclically and in series. To the chromatographic separation apparatus, a raw material fluid containing at least several tens of percent of tocopherol and tocotrienol and consisting substantially 100% of oil constituents and an eluent of ethanol-water=90/10 are supplied so that a fraction fluid enriched with tocotrienol is separated from tocopherol. With this configuration, preparation of tocotrienol from a raw material fluid containing a large amount of tocopherol and tocotrienol can be achieved in a commercial scale through a method not too different from the conventionally known simulated moving bed type chromatographic separation and the initial investment cost and running cost can be reduced.

Abstract: This invention relates to an inhibitor having inhibitory activity against neovasculation, cell multiplication, lumen formation and fibroblast growth factor which comprises &bgr;-, &ggr;- or &dgr;-tocotrienol.

Abstract: A tocotrienol-containing powder prepared by a process wherein an oil containing a tocotrienol is treated with a lecithin, a cellulose and an emulsifying agent in water to form an emulsion, a powder substance is mixed with the formed emulsion to form a suspension and then the formed suspension is spray-dried. The powder containing tocotrienol, which has excellent storage stability and free flowability, can be used in preparing a tablet which comprises the powder compressed into a tablet form.

Abstract: A coated antacid comprising sucralfate and an antacid inhibits decline in the adhesion characteristics of sucralfate whereby the drug ingested can reliably show its effect in the stomach. This coated antacid not only shows the mucosa repairing effect of sucralfate itself, but also shows the antacid effect and the gastric mucosa protective effect of the coated antacid, thereby synergistically producing an excellent antiulcer effect and an excellent ulcer inhibiting/healing effect.

Abstract: This invention relates to an inhibitor having inhibitory activity against neovasculation, cell multiplication, lumen formation and fibroblast growth factor which comprises &bgr;-, &ggr;- or &dgr;-tocotrienol.

Abstract: The present invention provides an agent for ischemic disease, for improving deformability of erythrocyte membranc and for improving peripheral circulation, cohich comprises a tocotrienol compound as an active component.

Abstract: The improved pharmaceutical preparation for oral administration which is adapted to release the drug at appropriate sites in the intestines comprises: a core that comprises an active ingredient and a pharmaceutically acceptable excipient, a first layer that covers the core and which comprises an enteric or water-soluble ingredient and an optional insoluble ingredient, a second layer that covers the first layer and which comprises a non-enteric ingredient that dissolves upon reacting with at least one ingredient in the core, and a third layer that covers the second layer and which comprises an enteric ingredient. This preparation is characterized in that it will not release the active ingredient until after it reaches a desired site in the intestines and that, in addition, it is capable of controlling the rate at which the active ingredient is released after it has reached the desired site.

Abstract: A stable solid thiol ester derivative preparation which contains as active ingredients a thiol ester derivative or a salt thereof, a water-soluble wax which is solid at ordinary temperatures, and sodium carboxymethyl starch and/or a monovalent electrolyte. Thiol ester derivatives are very useful as drugs but, in a solid state, they are sensitive to moisture. A stable solid preparation of thiol ester derivative is obtained by mixing the above additives and/or a monovalent electrolyte into a thiol ester derivative.