Patents by Inventor Heiko Kroth

Heiko Kroth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gamma-carboline compounds for the detection of Tau aggregates
    Patent number: 11306089
    Abstract: The present invention relates to novel compounds of the formula (II) and formula (III) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
    Type: Grant
    Filed: January 22, 2019
    Date of Patent: April 19, 2022
    Assignee: LIFE MOLECULAR IMAGING LIMITED
    Inventors: Mathias Berndt, Andre Müller, Felix Oden, Hanno Schieferstein, Heribert Schmitt-Willich, Heiko Kroth, Jérôme Molette
  • Novel Compounds for the Treatment, Alleviation or Prevention of Disorders Associated with Tau Aggregates
    Publication number: 20210214371
    Abstract: The present invention relates to novel compounds that can be employed in the treatment, alleviation or prevention of a group of disorders and abnormalities associated with Tau (Tubulin associated unit) protein aggregates including, but not limited to, Neurofibrillary Tangles (NFTs), such as Alzheimer's disease (AD).
    Type: Application
    Filed: May 20, 2019
    Publication date: July 15, 2021
    Inventors: Sreenivasachary Nampally, Emanuele Gabellieri, Jerome Molette, Heiko Kroth, Cedric Boudou
  • GAMMA-CARBOLINE COMPOUNDS FOR THE DETECTION OF TAU AGGREGATES
    Publication number: 20210047321
    Abstract: The present invention relates to novel compounds of the formula (II) and formula (III) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
    Type: Application
    Filed: January 22, 2019
    Publication date: February 18, 2021
    Inventors: Mathias BERNDT, Andre MÜLLER, Felix ODEN, Hanno SCHIEFERSTEIN, Heribert SCHMITT-WILLICH, Heiko KROTH, Jérôme MOLETTE
  • DIAGNOSTIC COMPOSITIONS FOR PET IMAGING, A METHOD FOR MANUFACTURING THE DIAGNOSTIC COMPOSITION AND ITS USE IN DIAGNOSTICS
    Publication number: 20210047327
    Abstract: The present application relates to a diagnostic composition comprising: a. a compound of Formula I, b. ethanol, c. water, and d. a hydroxycarboxylic acid, a salt of a hydroxycarboxylic acid or a mixture thereof. The diagnostic composition can be used in the selective detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease (AD) and other tauopathies, for example, using Positron Emission Tomography (PET). The present invention also relates to a method of preparing the claimed diagnostic composition.
    Type: Application
    Filed: January 22, 2019
    Publication date: February 18, 2021
    Inventors: Johnny CASTILLO MELEAN, Thomas BETZEL, Mathias BERNDT, Hanno SCHIEFERSTEIN, Heiko KROTH, Jérôme MOLETTE, Vincent DARMENCY, Emanuele GABELLIERI
  • NOVEL METHOD OF PREPARING AN IMAGING COMPOUND
    Publication number: 20210038747
    Abstract: The present invention relates to a novel method of preparing a compound of the formula I. Diagnostic compositions and their use in the selective detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease (AD) and other tauopathies, for example, using Positron Emission Tomography (PET) imaging are also disclosed.
    Type: Application
    Filed: January 22, 2019
    Publication date: February 11, 2021
    Inventors: Marion ZERNA, Mathias BERNDT, Hanno SCHIEFERSTEIN, Johnny CASTILLO MELEAN, Heiko KROTH, Jérôme MOLETTE, Vincent DARMENCY, Emanuele GABELLIERI
  • AZACARBOLINE COMPOUNDS FOR THE DETECTION OF TAU AGGREGATES
    Publication number: 20210041447
    Abstract: The present invention relates to novel compounds of the formula (II) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging. The present invention also discloses intermediates which are useful in the preparation of these compounds.
    Type: Application
    Filed: January 22, 2019
    Publication date: February 11, 2021
    Inventors: Mathias BERNDT, Andre MÜLLER, Felix ODEN, Hanno SCHIEFERSTEIN, Heribert SCHMITT-WILLICH, Heiko KROTH, Jérôme MOLETTE, Emanuele GABELLIERI, Cédric BOUDOU
  • Compounds for imaging Tau protein aggregates
    Patent number: 10865207
    Abstract: The present invention relates to novel compounds of the formula (I) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: December 15, 2020
    Assignees: AC IMMUNE S.A., LIFE MOLECULAR IMAGING SA
    Inventors: Heiko Kroth, Jérôme Molette, Hanno Schieferstein, Andre Müller, Heribert Schmitt-Willich, Mathias Berndt, Felix Oden
  • Compounds for imaging Tau protein aggregates
    Patent number: 10835624
    Abstract: The present invention relates to novel compounds of the formula (II) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: November 17, 2020
    Assignees: AC IMMUNE S.A., LIFE MOLECULAR IMAGING SA
    Inventors: Heiko Kroth, Jérôme Molette, Vincent Darmency, Hanno Schieferstein, Andre Müller, Heribert Schmitt-Willich, Mathias Berndt, Felix Oden, Emanuele Gabellieri
  • Carbazole and carboline compounds for use in the diagnosis, treatment, alleviation or prevention of disorders associated with amyloid or amyloid-like proteins
    Patent number: 10662193
    Abstract: The present invention relates to novel compounds that can be employed in the diagnosis, treatment, alleviation or prevention of a group of disorders and abnormalities associated with amyloid proteins and amyloid-like proteins, such as Alzheimer's disease. Precursors for the preparation of the compounds according to the present invention are also provided.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: May 26, 2020
    Assignees: AC IMMUNE SA, LIFE MOLECULAR IMAGING SA
    Inventors: Heiko Kroth, Sreenivasachary Nampally, Jér{hacek over (o)}me Molette, Emanuele Gabellieri, Pascal André René Benderitter, Wolfgang Froestl, Hanno Schieferstein, Andre Mueller, Heribert Schmitt-Willich, Mathias Berndt
  • Compounds for the treatment of diseases associated with amyloid or amyloid-like proteins
    Patent number: 10500207
    Abstract: The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system. The present invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the preparation of medicaments for treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins. A method of treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins is also disclosed.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: December 10, 2019
    Assignee: AC IMMUNE SA
    Inventors: Heiko Kroth, Cotinica Hamel, Pascal Benderitter, Wolfgang Froestl, Nampally Sreenivasachary, Andreas Muhs
  • COMPOUNDS FOR IMAGING TAU PROTEIN AGGREGATES
    Publication number: 20190263817
    Abstract: The present invention relates to novel compounds of the formula (I) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
    Type: Application
    Filed: July 21, 2017
    Publication date: August 29, 2019
    Inventors: Heiko KROTH, Jerome MOLETTE, Hanno SCHIEFERSTEIN, Andre MULLER, Heribert SCHMITT-WILLICH, Mathias BERNDT, Felix ODEN
  • COMPOUNDS FOR IMAGING TAU PROTEIN AGGREGATES
    Publication number: 20190262480
    Abstract: The present invention relates to novel compounds of the formula (II) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
    Type: Application
    Filed: July 21, 2017
    Publication date: August 29, 2019
    Inventors: Heiko KROTH, Jérôme MOLETTE, Vicent DARMENCY, Hanno SCHIEFERSTEIN, Andre MÜLLER, Heribert SCHMITT-WILLICH, Mathias BERNDT, Felix ODEN, Emanuele GABELLIERI
  • NOVEL IMAGING COMPOUNDS
    Publication number: 20180264146
    Abstract: The present invention relates to novel compounds that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
    Type: Application
    Filed: July 15, 2016
    Publication date: September 20, 2018
    Applicants: AC IMMUNE S.A., PIRAMAL IMAGING SA
    Inventors: Heiko KROTH, Sreenivasachary NAMPALLY, Jérôme MOLETTE, Emanuele GABELLIERI, Hanno SCHIEFERSTEIN, Andre MÜLLER, Heribert SCHMITT-WILLICH, Mathias BERNDT
  • 2,6-diaminopyridine compounds suitable for treating diseases associated with amyloid or amyloid-like proteins or for treating or preventing ocular diseases or conditions associated with a pathological abnormality/change in the tissue of the visual system
    Patent number: 9701660
    Abstract: The present invention relates to 2,6-diaminopyridine compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: July 11, 2017
    Assignee: AC Immune S.A.
    Inventors: Heiko Kroth, Wolfgang Froestl, Andrea Pfeifer, Andreas Muhs
  • Carbazole and Carboline Compounds for Use in the Diagnosis, Treatment, Alleviation or Prevention of Disorders Associated with Amyloid or Amyloid-Like Proteins
    Publication number: 20170002005
    Abstract: The present invention relates to novel compounds that can be employed in the diagnosis, treatment, alleviation or prevention of a group of disorders and abnormalities associated with amyloid proteins and amyloid-like proteins, such as Alzheimer's disease. Precursors for the preparation of the compounds according to the present invention are also provided.
    Type: Application
    Filed: January 21, 2015
    Publication date: January 5, 2017
    Inventors: Heiko KROTH, Sreenivasachary NAMPALLY, Jérôme MOLETTE, Emanuele GABELLIERI, Pascal André René BENDERITTER, Wolfgang FROESTL, Hanno SCHIEFERSTEIN, Andre MUELLER, Heribert SCHMITT-WILLICH, Mathias BERNDT
  • Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins
    Publication number: 20160158242
    Abstract: The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system. The present invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the preparation of medicaments for treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins. A method of treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins is also disclosed.
    Type: Application
    Filed: November 2, 2015
    Publication date: June 9, 2016
    Inventors: Heiko KROTH, Cotinica HAMEL, Pascal BENDERITTER, Wolfgang FROESTL, Nampally SREENIVASACHARY, Andreas MUHS
  • Compounds for the treatment of diseases associated with amyloid or amyloid-like proteins
    Patent number: 9221812
    Abstract: The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system. The present invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the preparation of medicaments for treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins. A method of treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins is also disclosed.
    Type: Grant
    Filed: April 18, 2011
    Date of Patent: December 29, 2015
    Assignee: AC Immune SA
    Inventors: Heiko Kroth, Cotinica Hamel, Pascal Benderitter, Wolfgang Froestl, Nampally Sreenivasachary, Andreas Muhs
  • 2,6-Diaminopyridine Compounds Suitable for Treating Diseases Associated with Amyloid or Amyloid-Like Proteins or for Treating or Preventing Ocular Diseases or Conditions Associated with a Pathological Abnormality/Change in the Tissue of the Visual System
    Publication number: 20150023950
    Abstract: The present invention relates to 2,6-diaminopyridine compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system.
    Type: Application
    Filed: September 30, 2014
    Publication date: January 22, 2015
    Inventors: Heiko Kroth, Wolfgang Froestl, Andrea Pfeifer, Andreas Muhs
  • 2,6-diaminopyridine compounds suitable for treating diseases associated with amyloid or amyloid-like proteins or for treating or preventing ocular diseases or conditions associated with a pathological abnormality/change in the tissue of the visual system
    Patent number: 8916590
    Abstract: The present invention relates to 2,6-diaminopyridine compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: December 23, 2014
    Assignee: AC Immune SA
    Inventors: Heiko Kroth, Wolfgang Froestl, Andrea Pfeifer, Andreas Muhs
  • Heterobicyclic metalloprotease inhibitors
    Patent number: 8835441
    Abstract: The present invention relates generally to amide containing heterobicyclic compounds having the following formulas: wherein R1, R2, D, and Q are as defined in the specification. More particularly, the present invention provides a new class of amide containing heterobicyclic compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
    Type: Grant
    Filed: June 17, 2011
    Date of Patent: September 16, 2014
    Assignee: Amgen Inc.
    Inventors: Christoph Steeneck, Christian Gege, Frank Richter, Heiko Kroth, Matthias Hochgürtel, Michael Essers, Joshua van Veldhuizen, Bert Nolte, Brian M. Gallagher, Jr., Tim Feuerstein, Matthias Schneider, Torsten Arndt, Hongbo Deng, Ralf Biesinger, Xinyuan Wu, Harald Bluhm, Irving Sucholeiki, Arthur G. Taveras