Patents by Inventor Heinrich Josef Schostarez

Heinrich Josef Schostarez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Statine derivatives for the treatment of Alzheimer's disease
    Patent number: 7358264
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: March 8, 2005
    Date of Patent: April 15, 2008
    Assignee: Pharmacia & Upjohn Company
    Inventors: Heinrich Josef Schostarez, Robert Alan Chrusciel
  • Statine derivatives for the treatment of Alzheimer's disease
    Patent number: 7354943
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: March 8, 2005
    Date of Patent: April 8, 2008
    Assignee: Pharmacia & Upjohn
    Inventors: Heinrich Josef Schostarez, Robert Alan Chrusciel
  • Diaminediols for the treatment of Alzheimer's disease
    Patent number: 7067542
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: June 27, 2006
    Assignee: Pharmacia & Upjohn Company
    Inventors: Heinrich Josef Schostarez, Robert A. Chrusciel
  • Aminediols for the treatment of Alzheimer's disease
    Patent number: 7053109
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: May 30, 2006
    Assignee: Pharmacia & Upjohn Company
    Inventors: Heinrich Josef Schostarez, Robert Alan Chrusciel
  • Aminediols for the treatment of Alzheimer's disease
    Patent number: 6906104
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: June 13, 2002
    Date of Patent: June 14, 2005
    Assignee: Pharmacia & Upjohn Company
    Inventors: Heinrich Josef Schostarez, Robert Alan Chrusciel
  • Statine derivatives for the treatment of Alzheimer's disease
    Patent number: 6864290
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: March 8, 2005
    Assignee: Pharmacia & Upjohn, LLP
    Inventors: Heinrich Josef Schostarez, Robert Alan Chrusciel
  • Methods for treating alzheimer's disease using quinaldoyl-amine derivatives of oxo-and hydroxy-substituted hydrocarbons
    Publication number: 20040266871
    Abstract: Disclosed are methods for treating Alzheimer's disease, and other diseases, and/or inhibiting beta-secretase enzyme, inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of compounds of of compounds of formula (I) wherein R1, R2, R3. and N, are defined herein.
    Type: Application
    Filed: August 20, 2004
    Publication date: December 30, 2004
    Inventor: Heinrich Josef Schostarez
  • Aminediols for the treatment of Alzheimer's disease
    Publication number: 20040019086
    Abstract: The present invention relates to compounds of formula (I): 1
    Type: Application
    Filed: July 10, 2002
    Publication date: January 29, 2004
    Inventors: Heinrich Josef Schostarez, Robert Alan Chrusciel
  • Aminediols for the treatment of Alzheimer's disease
    Publication number: 20030092747
    Abstract: The present invention relates to compounds of formula (I): 1
    Type: Application
    Filed: June 13, 2002
    Publication date: May 15, 2003
    Inventors: Heinrich Josef Schostarez, Robert Alan Chrusciel
  • Statine derivatives for the treatment of Alzheimer's disease
    Publication number: 20030083356
    Abstract: The present invention relates to compounds of formula (I): 1
    Type: Application
    Filed: July 10, 2002
    Publication date: May 1, 2003
    Inventors: Heinrich Josef Schostarez, Robert Alan Chrusciel
  • Diaminediols for the treatment of Alzheimer's disease
    Publication number: 20030083353
    Abstract: The present invention relates to compounds of formula (I): 1
    Type: Application
    Filed: July 10, 2002
    Publication date: May 1, 2003
    Inventors: Heinrich Josef Schostarez, Robert A. Chrusciel
  • Inhibitors of protein tyrosine phosphatase
    Patent number: 6410585
    Abstract: The present invention comprises small molecular weight, non-peptidic inhibitors of formulae I-VII of Protein Tyrosine Phosphatase 1 (PTP1) which are useful for the treatment and/or prevention of Non-Insulin Dependent Diabetes Mellitus (NIDDM).
    Type: Grant
    Filed: March 10, 1999
    Date of Patent: June 25, 2002
    Inventors: Scott D. Larsen, Paul D. May, John E. Bleasdale, Charlotta Liljebris, Heinrich Josef Schostarez, Tjeerd Barf, Marianne Nilsson
  • Inhibitors of protein tyrosine phosphatase
    Patent number: 6353023
    Abstract: The present invention comprises small molecular weight, non-peptidic inhibitors of formula I and II of Protein Tyrosine Phosphatase 1 (PTP1) which are useful for the treatment and/or prevention of Non-Insulin Dependent Diabetes Mellitus (NIDDM).
    Type: Grant
    Filed: August 24, 1998
    Date of Patent: March 5, 2002
    Assignee: Pharmacia & Upjohn Company
    Inventors: Scott D. Larsen, Paul D. May, John E. Bleasdale, Charlotta Liljebris, Heinrich Josef Schostarez, Tjeerd Barf
  • Thiadiazole amide MMP inhibitors
    Patent number: 5830869
    Abstract: The present invention provides novel thiadiazole amide derivatives represented by formula I ##STR1## The compounds of the present invention inhibit various enzymes from the matrix metalloproteinase family, predominantly stromelysins, and hence are useful for the treatment of matrix metallo endoproteinase diseases such as osteoarthritis, rheumatoid arthritis, septic arthritis, osteopenias such as osteoporosis, tumor metastasis, periodontitis, gingivitis, corneal ulceration, dermal ulceration, gastric ulceration, inflammation and other diseases related to connective tissue degradation.
    Type: Grant
    Filed: June 18, 1997
    Date of Patent: November 3, 1998
    Inventors: Mark Allen Mitchell, Heinrich Josef Schostarez, Linda Louise Maggiora, Thomas J. Lindberg
  • 4-hydroxycoumarin-3-carboxamides for the treatment of diabetes mellitus
    Patent number: 5723476
    Abstract: The present invention provides some novel 4-hydroxycoumarin-3-carboxamide derivatives and the use of a broad class of 4-hydroxycoumarin-3-carboxamide derivatives for the treatment of a patient suffering from or susceptible to diabetes mellitus.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: March 3, 1998
    Assignee: Pharmacia & Upjohn Company
    Inventors: Scott D. Larsen, Jerry R. Colca, Peter K. W. Harris, Howard R. Miller, Alice L. Laborde, Rolf F. Kletzien, Heinrich Josef Schostarez