Patents by Inventor Heinz W. Gschwend
Heinz W. Gschwend has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9512125Abstract: The present invention provides anti-inflammatory compounds useful in the treatment of diseases and conditions in which inflammation is involved in disease progression or the manifestation of symptoms of the disease or condition.Type: GrantFiled: November 21, 2005Date of Patent: December 6, 2016Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Kevan M. Shokat, Nikolai Sepetov, Chao Zhang, Heinz W. Gschwend, Eric J. Kunkel
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Publication number: 20130079354Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein W, V, x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.Type: ApplicationFiled: September 14, 2012Publication date: March 28, 2013Applicant: Xenon Pharmaceuticals Inc.Inventors: Melwyn ABREO, Daniel F. HARVEY, Mikhail A. KONDRATENKO, Wenbao LI, Rajender KAMBOJ, Vishnumurthy KODUMURU, Michael D. WINTHER, Heinz W. GSCHWEND, Nagasree CHAKKA, Shifeng LIU, Serguei SVIRIDOV, Shaoyi SUN
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Patent number: 8383628Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein W, V, x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.Type: GrantFiled: June 15, 2010Date of Patent: February 26, 2013Assignee: Xenon Pharmaceuticals Inc.Inventors: Melwyn Abreo, Daniel F. Harvey, Mikhail A. Kondratenko, Wenbao Li, Rajender Kamboj, Vishnumurthy Kodumuru, Michael D. Winther, Heinz W. Gschwend, Nagasree Chakka, Shifeng Liu, Serguei Sviridov, Shaoyi Sun
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Patent number: 8153636Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein x, y, W, V, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.Type: GrantFiled: September 2, 2009Date of Patent: April 10, 2012Assignee: Xenon Pharmaceuticals Inc.Inventors: Melwyn Abreo, Daniel F. Harvey, Heinz W. Gschwend, Wenbao Li, Chi Tu, Rajender Kamboj, Michael D. Winther, Vishnumurthy Kodumuru, Cindy J. Hudson, Mikhail A. Kondratenko, Shifeng Liu, Vandna Raina, Serguei Sviridov, Zaihui Zhang, Mehran Seid Bagherzadeh, Shaoyi Sun
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Pyridazine derivatives and their use as inhibitors of stearoyl-CoA desaturase-1 activity in a mammal
Patent number: 8148378Abstract: A method of treating an SCD-mediated disease or condition in a mammal, preferably a human, includes administering to a mammal a compound of formula (I): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. The SCD-mediated disease or condition may be selected from the group consisting of Type II diabetes, impaired glucose tolerance, insulin resistance, obesity, fatty liver, non-alcoholic steatohepatitis, dyslipidemia, metabolic syndrome, acne, cardiovascular disease, hypertriglyceridemia, inflammation, cancer, and any combination of these.Type: GrantFiled: February 20, 2009Date of Patent: April 3, 2012Assignee: Xenon Pharmaceuticals Inc.Inventors: Heinz W. Gschwend, Vishnumurthy Kodumuru, Shifeng Liu, Rajender Kamboj -
Patent number: 8030488Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R2, R3, R4, R5, R6, R7, R8, R8a, R9, R9a, R10, R10a, R11 and R11a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.Type: GrantFiled: October 8, 2008Date of Patent: October 4, 2011Assignee: Xenon Pharmaceuticals Inc.Inventors: Serguei Sviridov, Vishnumurthy Kodumuru, Shifeng Liu, Melwyn Abreo, Michael D. Winther, Heinz W. Gschwend, Rajender Kamboj, Shaoyi Sun, Mark W. Holladay, Wenbao Li, Chi Tu
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Publication number: 20110144134Abstract: The present invention provides anti-inflammatory compounds useful in the treatment of diseases and conditions in which inflammation is involved in disease progression or the manifestation of symptoms of the disease or condition.Type: ApplicationFiled: January 31, 2011Publication date: June 16, 2011Applicant: The Regents of the University of CaliforniaInventors: Kevan M. Shokat, Nikolai Sepetov, Chao Zhang, Heinz W. Gschwend, Eric J. Kunkel
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Patent number: 7919484Abstract: This invention is directed to the use of SCD-1 inhibitors of the formula (I): where x, y, V, W, G, J, L, M, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein, in combination with other drug therapies to treat adverse weight gain.Type: GrantFiled: February 8, 2006Date of Patent: April 5, 2011Assignee: Xenon Pharmaceuticals Inc.Inventors: Rajender Kamboj, Michael D. Winther, Robert Fraser, Mikhail Chafeev, Sultan Chowdhury, Jian-Min Fu, Duanjie Hou, Shifeng Liu, Vandna Raina, Mehran Seid Bagherzadeh, Serguei Sviridov, Kashinath Sadalapure, Shaoyi Sun, Vishnumurthy Kodumuru, Nagasree Chakka, Zaihui Zhang, Melwyn Abreo, Mikhail A. Kondratenko, Daniel F. Harvey, Cindy J. Hudson, Wenbao Li, Chi Tu, Sengen Sun, Mark W. Holladay, Heinz W. Gschwend
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Publication number: 20100305138Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein W, V, x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.Type: ApplicationFiled: June 15, 2010Publication date: December 2, 2010Inventors: Melwyn Abreo, Daniel F. Harvey, Mikhail A. Kondratenko, Wenbao Li, Rajender Kamboj, Vishnumurthy Kodumuru, Michael D. Winther, Heinz W. Gschwend, Nagasree Chakka, Shifeng Liu, Serguei Sviridov, Shaoyi Sun
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Patent number: 7763618Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein W, V, x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.Type: GrantFiled: July 29, 2004Date of Patent: July 27, 2010Assignee: Xenon Pharmaceuticals Inc.Inventors: Melwyn Abreo, Daniel F. Harvey, Mikhail A. Kondratenko, Wenbao Li, Rajender Kamboj, Vishnumurthy Kodumuru, Michael D. Winther, Heinz W. Gschwend, Nagasree Chakka, Shifeng Liu, Serguei Sviridov, Shaoyi Sun
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Patent number: 7754711Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (Ia): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.Type: GrantFiled: February 9, 2005Date of Patent: July 13, 2010Assignee: Xenon Pharmaceuticals Inc.Inventors: Nagasree Chakka, Mikhail Chafeev, Sultan Chowdhury, Jian-Min Fu, Duanjie Hou, Rajender Kamboj, Vishnumurthy Kodumuru, Shifeng Liu, Vandna Raina, Shaoyi Sun, Serguei Sviridov, Michael D. Winther, Zaihui Zhang, Melwyn Abreo, Mark W. Holladay, Wenbao Li, Sengen Sun, Chi Tu, Heinz W. Gschwend
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Publication number: 20100048584Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein x, y, W, V, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.Type: ApplicationFiled: September 2, 2009Publication date: February 25, 2010Applicant: XENON PHARMACEUTICALS INC.Inventors: Melwyn Abreo, Daniel F. Harvey, Heinz W. Gschwend, Wenbao Li, Chi Tu, Rajender Kamboj, Michael D. Winther, Vishnumurthy Kodumuru, Cindy J. Hudson, Mikhail A. Kondratenko, Shifeng Liu, Vandna Raina, Serguei Sviridov, Zaihui Zhang, Mehran Seid Bagherzadeh, Shaoyi Sun
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Patent number: 7605161Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein: W is —O—, —N(R1)—, C(O), S(O)t; (where t is 0, 1 or 2), N(R1)S(O)2, S(O)2N(R1), C(O)N(R1) or N(R1)C(O)N(R1); and V is C(O), C(S), C(O)N(R1)—, C(O)O—, S(O)2—, S(O)2N(R1)— or C(R11)H; and x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.Type: GrantFiled: July 29, 2004Date of Patent: October 20, 2009Assignee: Xenon Pharmaceuticals Inc.Inventors: Melwyn Abreo, Daniel F. Harvey, Heinz W. Gschwend, Wenbao Li, Chi Tu, Rajender Kamboj, Michael D. Winther, Vishnumurthy Kodumuru, Cindy J. Hudson, Mikhail A. Kondratenko, Shifeng Liu, Vandna Raina, Serguei Sviridov, Zaihui Zhang, Mehran Seid Bagherzadeh, Shaoyi Sun
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Publication number: 20090197894Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where m, n, p, V, R1, R2, R3, R4, R5 and R6 are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.Type: ApplicationFiled: April 14, 2009Publication date: August 6, 2009Applicant: XENON PHARMACEUTICALS INC.Inventors: Jian-Min Fu, Vishnumurthy Kodumuru, Shaoyi Sun, Michael D. Winther, Richard M. Fine, Daniel F. Harvey, Boris Klebansky, Mark P. Gray-Keller, Heinz W. Gschwend, Wenbao Li
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Publication number: 20090197890Abstract: A method of treating an SCD-mediated disease or condition in a mammal, preferably a human, includes administering to a mammal a compound of formula (I): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein.Type: ApplicationFiled: February 20, 2009Publication date: August 6, 2009Applicant: XENON PHARMACEUTICALS INC.Inventors: Heinz W. Gschwend, Vishnumurthy Kodumuru, Shifeng Liu, Rajender Kamboj
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Publication number: 20090131447Abstract: This invention is directed to the use of SCD-1 inhibitors of the formula (I): where x, y, V, W, G, J, L, M, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein, in combination with other drug therapies to treat adverse weight gain.Type: ApplicationFiled: February 8, 2006Publication date: May 21, 2009Applicant: XENON PHARMACEUTICALS INC.Inventors: Rajender Kamboj, Michael D. Winther, Robert Fraser, Mikhail Chafeev, Sultan Chowdhury, Jian-Min Fu, Duanjie Hou, Shifeng Liu, Vandna Raina, Mehran Seid Bagherzadeh, Serguei Sviridov, Kashinath Sadalapure, Shaoyi Sun, Vishnumurthy Kodumuru, Nagasree Chakka, Zaihui Zhang, Melwyn Abreo, Mikhail A. Kondratenko, Daniel F. Harvey, Cindy J. Hudson, Wenbao Li, Chi Tu, Sengen Sun, Mark W. Holladay, Heinz W. Gschwend
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Publication number: 20090124638Abstract: The present invention provides anti-inflammatory compounds useful in the treatment of diseases and conditions in which inflammation is involved in disease progression or the manifestation of symptoms of the disease or condition.Type: ApplicationFiled: November 21, 2005Publication date: May 14, 2009Applicants: Regents of the University of California, BIOSEEK, INC.Inventors: Kevan M. Shokat, Nikolai Sepetov, Chao Zhang, Heinz W. Gschwend, Eric J. Kunkel
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Patent number: 7514436Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.Type: GrantFiled: July 29, 2004Date of Patent: April 7, 2009Assignee: Xenon Pharmaceuticals Inc.Inventors: Heinz W. Gschwend, Vishnumurthy Kodumuru, Shifeng Liu, Rajender Kamboj
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Publication number: 20090030008Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R2, R3, R4, R5, R6, R7, R8, R8a, R9, R9a, R10, R10a, R11 and R11a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.Type: ApplicationFiled: October 8, 2008Publication date: January 29, 2009Applicant: XENON PHARMACEUTICALS INC.Inventors: Serguei Sviridov, Vishnumurthy Kodumuru, Shifeng Liu, Melwyn Abreo, Michael D. Winther, Heinz W. Gschwend, Rajender Kamboj, Shaoyi Sun, Mark W. Holladay, Wenbao Li, Chi Tu
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Patent number: 7456180Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R2, R3, R4, R5, R6, R7, R8, R8a, R9, R9a, R10, R10a, R11 and R11a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.Type: GrantFiled: July 29, 2004Date of Patent: November 25, 2008Assignee: Xenon Pharmaceuticals Inc.Inventors: Serguei Sviridov, Vishnumurthy Kodumuru, Shifeng Liu, Melwyn Abreo, Michael D. Winther, Heinz W. Gschwend, Rajender Kamboj, Shaoyi Sun, Mark W. Holladay, Wenbao Li, Chi Tu