Patents by Inventor Heinz-Werner Kleeman

Heinz-Werner Kleeman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7446225
    Abstract: The invention relates to pentafluorosulfanylphenyl-substituted benzoylguanidines of the formula I: and a process for preparing a compound of the formula I and/or the pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: March 9, 2007
    Date of Patent: November 4, 2008
    Assignee: Sanofi-aventis Deutschland GmbH
    Inventor: Heinz-Werner Kleeman
  • Patent number: 6600072
    Abstract: Substituted 1-naphthoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them. Substituted 1-naphthoylguanidines of the formula I in which R2 to R8 have the meanings indicated in the claims, are suitable as antiarrhythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and infarct treatment and for the treatment of angina pectoris. They also preventively inhibit the pathophysiological processes in the formation of ischemically induced damage, in particular in the production of ischemically induced cardiac arrhythmias.
    Type: Grant
    Filed: August 14, 2002
    Date of Patent: July 29, 2003
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Joachim Brendel, Heinz-Werner Kleeman, Heinrich Christian Englert, Hans Jochen Lang, Udo Albus, Bansi Lal, Anil Vasantrao Ghate
  • Publication number: 20030013719
    Abstract: Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations including their use as antiarrhythmic active compounds, for example, for the treatment and prophylaxis of atrial arrhythmias, e.g. atrial fibrillation (AF) or atrial flutters.
    Type: Application
    Filed: November 29, 2001
    Publication date: January 16, 2003
    Inventors: Stefan Peukert, Joachim Brendel, Horst Hemmerle, Heinz-Werner Kleeman
  • Patent number: 5665739
    Abstract: Benzoylguanidines of the formula I are described ##STR1## in which R(1)=hydrogen, Hal, --NO.sub.2, --C.tbd.N, --CF.sub.3, R(4)--SO.sub.m or R(5)R(6)N--SO.sub.2 --, R(4) and R(5) are alk(en)yl or CF.sub.3, R(5) also having the meaning of H,R(2)=is heteroaryl or --SR(10), --OR(10), --NR(10)R(11), --CR(10)R(11)R(12); where R(10) is --C.sub.a H.sub.2a -heteroaryl, and R(11) and R(12) are as defined for R(10) and also hydrogen or alkyl,R(3) is as defined for R(1) or is alkyl, --X--R(13) where X is oxygen, S, NR(14), where R(13) is H or (cyclo)alkyl.They are obtained from a compound of the formula II ##STR2## by reacting it with guanidine.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: September 9, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hans-Jochen Lang, Heinz-Werner Kleeman, Wolfgang Scholz, Udo Albus
  • Patent number: 5169841
    Abstract: The invention relates to compounds of the formula 1 ##STR1## in which A.sup.1 denotes a radical of the formulae ##STR2## A.sup.2 is absent or represents a radical of the formula ##STR3## R.sup.2, R.sup.3 and R.sup.4 are as defined in the specification, and X and Y, independently of one another, represent --O-- or --NR.sup.13 --, and to the salts thereof. Also described is a process for the preparation of the compounds of the formula 1, corresponding pharmaceutical products, and the use thereof as medicines, and intermediates for the preparation of these compounds.
    Type: Grant
    Filed: November 3, 1988
    Date of Patent: December 8, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Heinz-Werner Kleeman, Hansjorg Urbach, Dieter Ruppert, Bernward Scholkens