Patents by Inventor HELEN BURT
HELEN BURT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9186410Abstract: Herein are provided derivatized hyperbranched polyglycerols (“dHPGs”). The dHPG comprises a core comprising a hyperbranched polyglycerol derivatized with C1C20 alkyl chains and a shell comprising at least one hydrophilic substituent bound to hydroxyl groups of the core, wherein the hyperbranched polyglycerol comprises from about 1 to about 200 moles of the at least one hydrophilic substituent. The dHPGs are for use as agents for the delivery of a drug or other biologically active moiety to the urinary tract, the digestive tract, the airways, the vaginal cavity and cervix and the peritoneal cavity to treat indications such as cancer, which may be useful in the treatment of or the manufacture of a medicament, in the preparation, of a pharmaceutical composition for the treatment of cancer, as a pre-treatment or co-treatment to improve drug uptake in a tissue. Furthermore, there are provided methods of making dHPGs.Type: GrantFiled: March 1, 2011Date of Patent: November 17, 2015Assignees: The University of British Columbia, Centre for Drug Research and DevelopmentInventors: Helen Burt, Donald Brooks, Jayachandran Kizhakkedathu, Richard Liggins, Dechi Guan, Lu Ye, Clement Mugabe, Alan So, Martin E. Gleave, John K. Jackson, Rajesh Kumar Kainthan
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Publication number: 20080020063Abstract: The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and taxol. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.Type: ApplicationFiled: July 30, 2007Publication date: January 24, 2008Inventors: William HUNTER, Lindsay Machan, A. Arsenault, Helen Burt, John Jackson, Stephen Dordunoo
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Publication number: 20070298123Abstract: The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and taxol. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.Type: ApplicationFiled: July 30, 2007Publication date: December 27, 2007Inventors: William Hunter, Lindsay Machan, A. Arsenault, Helen Burt, John Jackson, Stephen Dordunoo
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Publication number: 20070238697Abstract: Compositions, methods and the like comprising fucans such as fucoidan to treat surgical adhesions, arthritis, and psoriasis.Type: ApplicationFiled: December 5, 2006Publication date: October 11, 2007Inventors: John Jackson, Helen Burt
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Publication number: 20070003629Abstract: The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.Type: ApplicationFiled: May 18, 2006Publication date: January 4, 2007Applicant: ANGIOTECH PHARMACEUTICALS, INC.Inventors: William Hunter, Lindsay Machan, A. Arsenault, Helen Burt, John Jackson, Stephen Dordunoo
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Publication number: 20070003630Abstract: The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.Type: ApplicationFiled: May 18, 2006Publication date: January 4, 2007Applicant: ANGIOTECH PHARMACEUTICALS, INC.Inventors: William Hunter, Lindsay Machan, A. Larry-Arsenault, Helen Burt, John Jackson, Stephen Dordunoo
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Publication number: 20060240113Abstract: The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and taxol. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.Type: ApplicationFiled: May 18, 2006Publication date: October 26, 2006Applicant: ANGIOTECH PHARMACEUTICALS, INC.Inventors: William Hunter, Lindsay Machan, A. Arsenault, Helen Burt, John Jackson, Stephen Dordunoo
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Publication number: 20060189785Abstract: This invention provides compositions comprising a hydrophobic drug, a biocompatible micelle forming polymer, and a biocompatible low molecular weight, water-soluble polymer. Also provided are devices for injection of such compositions and for the use of such compositions to form hydrophobic drug containing micelles within the body of a patient.Type: ApplicationFiled: December 6, 2005Publication date: August 24, 2006Inventors: John Jackson, Jason Zastre, Helen Burt
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Publication number: 20060127445Abstract: The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.Type: ApplicationFiled: June 14, 2005Publication date: June 15, 2006Applicant: ANGIOTECH PHARMACEUTICALS, INC.Inventors: William Hunter, Lindsay Machan, A. Arsenault, Helen Burt, John Jackson, Stephen Dordunoo
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Publication number: 20060121117Abstract: The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.Type: ApplicationFiled: January 17, 2006Publication date: June 8, 2006Applicant: ANGIOTECH PHARMACEUTICALS, INC.Inventors: William Hunter, Lindsay Machan, A. Arsenault, Helen Burt, John Jackson, Stephen Dordunoo
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Publication number: 20050208137Abstract: The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and taxol. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.Type: ApplicationFiled: October 7, 2004Publication date: September 22, 2005Applicant: ANGIOTECH PHARMACEUTICALS, INC.Inventors: William Hunter, Lindsay Machan, A. Arsenault, Helen Burt, John Jackson, Stephen Dordunoo
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Publication number: 20050123605Abstract: The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and taxol. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.Type: ApplicationFiled: October 7, 2004Publication date: June 9, 2005Inventors: William Hunter, Lindsay Machan, A. Larry-Arsenault, Helen Burt, John Jackson, Stephen Dordunoo
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Publication number: 20050119216Abstract: Compositions, methods and the like comprising fucans such as fucoidan to treat surgical adhesions, arthritis, and psoriasis.Type: ApplicationFiled: October 5, 2004Publication date: June 2, 2005Inventors: John Jackson, Helen Burt
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Publication number: 20050074496Abstract: Compositions, methods and the like comprising fucans such as fucoidan to treat surgical adhesions, arthritis, and psoriasis.Type: ApplicationFiled: September 13, 2004Publication date: April 7, 2005Inventors: John Jackson, Helen Burt
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Publication number: 20050042293Abstract: Biodegradable polymeric implants can provide a safe and efficient means to deliver drugs in the treatment of various diseases. Although a polymeric drug delivery system can be implanted as a solid device within a subject, it is also possible to administer such a system as an injectable liquid which solidifies in vivo. An improved formulation of a polymeric drug delivery system comprises a water insoluble copolymer that is a solid or wax at 37° C., a water soluble polymer that is a liquid at 25° C., and a hydrophobic drug. These drug delivery systems can be administered by injection, and do not require the use of a toxic curing agent or inconvenient temperature manipulations.Type: ApplicationFiled: November 25, 2003Publication date: February 24, 2005Applicants: The University of British Columbia, Angiotech Pharmaceuticals, Inc.Inventors: John Jackson, Xichen Zhang, Helen Burt
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Publication number: 20040224914Abstract: A therapeutic method for treatment of non-cancerous angiogenesis-related diseases involves administering a therapeutically effective amount of a composition effective to reduce the effective amount of clusterin in the individual. Preferred therapeutic compositions contain antisense oligonucleotides which reduce the effective amount of clusterin.Type: ApplicationFiled: April 19, 2004Publication date: November 11, 2004Applicant: The University of British ColumbiaInventors: John K. Jackson, Helen Burt, Christopher Springate, Martin Gleave
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Publication number: 20040220131Abstract: Cancerous angiogenesis-related diseases treated, and angiogenesis is reduced by administration of a therapeutically effective amount of a composition effective to reduce the effective amount of clusterin in an individual. Preferred therapeutic compositions comprise antisense oligonucleotides which reduce the effective amount of clusterin.Type: ApplicationFiled: April 19, 2004Publication date: November 4, 2004Applicant: The University of British ColumbiaInventors: John K. Jackson, Helen Burt, Christopher Springate, Martin Gleave
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Publication number: 20020164374Abstract: Biodegradable polymeric implants can provide a safe and efficient means to deliver drugs in the treatment of various diseases. Although a polymeric drug delivery system can be implanted as a solid device within a subject, it is also possible to administer such a system as an injectable liquid which solidifies in vivo. An improved formulation of a polymeric drug delivery system comprises a water insoluble copolymer that is a solid or wax at 37° C., a water soluble polymer that is a liquid at 25° C., and a hydrophobic drug. These drug delivery systems can be administered by injection, and do not require the use of a toxic curing agent or inconvenient temperature manipulations.Type: ApplicationFiled: October 28, 1998Publication date: November 7, 2002Inventors: JOHN JACKSON, XICHEN ZHANG, HELEN BURT