Patents by Inventor Helena Domingues

Helena Domingues has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified cytokine
    Patent number: 7112660
    Abstract: The invention relates to methods for the stabilisation of cytokines and to cytokines generated by such methods. The methods of the invention involve mutating the amino acid sequence of a cytokine so as to remove solvent-exposed hydrophobic residues, and/or mutating the amino acid sequence of the cytokine so as to stabilise one or more secondary structure elements in the molecule. These steps have the effect of destabilsing intermediates that are formed during the folding process, relative to the stability of the cytokine in its naturally folded state, so increasing the yield of the cytokine as produced in vitro.
    Type: Grant
    Filed: May 23, 2000
    Date of Patent: September 26, 2006
    Assignees: European Molecular Biology Laboratory, Bayer AG
    Inventors: Helena Domingues, Hartmut Oschkinat, Luis Serrano, Joerg Peters
  • Coiled-coil dimer derived antagonists of 4-helix bundle cytokines, design and uses thereof
    Patent number: 6685932
    Abstract: The design of antagonists of 4-helix bundle cytokine specific receptors, mimetic peptides that are able to act as such antagonists and their use as pharmaceutical agents is disclosed.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: February 3, 2004
    Assignee: Europaisches Laboratorium Molekularbiologie
    Inventors: Helena Domingues, David Cregut, Walter Sebald, Hartmut Oschkinat, Luis Serrano