Patents by Inventor Helena Maria Johanna Dekker-Vlaar

Helena Maria Johanna Dekker-Vlaar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Homologous recombination in mismatch repair inactivated eukaryotic cells
    Patent number: 7199280
    Abstract: A mammalian cell having a mismatch repair-deficient phenotype is provided, where one or both alleles of a gene essential for mismatch repair, such as an Msh gene, are inactivated. Using this cell in a gene knock-out methodology advantageously allows efficient homologous recombination, even when the DNA sequences of the donor and recipient sequences diverge by significantly more than 0.6%.
    Type: Grant
    Filed: June 20, 2001
    Date of Patent: April 3, 2007
    Assignee: Mixis France S.A.
    Inventors: Henricus Petrus Joseph Te Riele, Niels De Wind, Helena Maria Johanna Dekker-Vlaar
  • Homologous recombination in mismatch repair inactivated eukaryotic cells
    Publication number: 20030221208
    Abstract: A mammalian cell having a mismatch repair-deficient phenotype is provided, where one or both alleles of a gene essential for mismatch repair, such as an Msh gene, are inactivated. Using this cell in a gene knock-out methodology advantageously allows efficient homologous recombination, even when the DNA sequences of the donor and recipient sequences diverge by significantly more than 0.6%.
    Type: Application
    Filed: February 12, 2003
    Publication date: November 27, 2003
    Applicant: Mixis France S.A.
    Inventors: Henricus Petrus Joseph Te Riele, Niels De Wind, Helena Maria Johanna Dekker-Vlaar
  • Homologous recombination in mismatch repair inactivated eukaryotic cells
    Publication number: 20020151059
    Abstract: A mammalian cell having a mismatch repair-deficient phenotype is provided, where one or both alleles of a gene essential for mismatch repair, such as an Msh gene, are inactivated. Using this cell in a gene knock-out methodology advantageously allows efficient homologous recombination, even when the DNA sequences of the donor and recipient sequences diverge by significantly more than 0.6%.
    Type: Application
    Filed: June 20, 2001
    Publication date: October 17, 2002
    Inventors: Henricus Petrus Joseph Te Riele, Niels De Wind, Helena Maria Johanna Dekker-Vlaar