Patents by Inventor Helene Crassier

Helene Crassier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MOLECULES WITH SOLUBILITY TAG AND RELATED METHODS
    Publication number: 20240058456
    Abstract: The present disclosure relates to molecules with a solubility tag, wherein the solubility tag comprises a chito-oligosaccharide, and to methods for increasing the solubility of a molecule. Moreover, the present disclosure relates to antibody-drug conjugates with solubility tag, methods and compounds for preparing such antibody-drug conjugates, methods for increasing the solubility of antibody-drug conjugates, antibody-drug conjugates prepared by such methods, as well as the use of such antibody-drug conjugates in medical treatment.
    Type: Application
    Filed: September 17, 2021
    Publication date: February 22, 2024
    Inventors: Carl Deutsch, Sven Kelly, Helene Crassier, Christoph Korpus, Joerg von Hagen, Ulrike Richter-Sander
  • N,N?-diphenylurea derivatives suitable as kinase inhibitors
    Patent number: 7846927
    Abstract: Compounds of the formula (I), in which R1, R3 and X have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours.
    Type: Grant
    Filed: October 12, 2005
    Date of Patent: December 7, 2010
    Assignee: Merck Patent GmbH
    Inventors: Guenter Hoelzemann, Helene Crassier, Alfred Jonczyk, Wilfried Rautenberg
  • Pyrazole derivatives
    Patent number: 7767696
    Abstract: Compounds of the formula (I), in which R1 and R2 have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases, and can be employed, inter alia, for the treatment of tumours.
    Type: Grant
    Filed: March 8, 2006
    Date of Patent: August 3, 2010
    Assignee: Merck Patent GmbH
    Inventors: Guenter Hoelzemann, Helene Crassier, Wilfried Rautenberg
  • 4-Amino-5-oxo-8-phenyl-5H-pyrido(2,3-D) pyrimidine derivatives as tyrosine kinase and raf kinase inhibitors for the treatment of tumours
    Patent number: 7745434
    Abstract: Compounds of the formula (I), in which R6, R7, R8, R9, Het1, X and X? have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours.
    Type: Grant
    Filed: October 20, 2005
    Date of Patent: June 29, 2010
    Assignee: Merck Patent GmbH
    Inventors: Guenter Hoelzemann, Karl-August Ackermann, Helene Crassier, Alfred Jonczyk, Wilfried Rautenberg, Gema Tarrason, Elisabet Rosell-Vives, Jaume Adan, Claudia Cases
  • Pyrazole derivatives having tyrosine kinase inhibitory activity
    Patent number: 7662827
    Abstract: Compounds of the formula (I), in which R, X, R1, R2, R3 and R4 have the meanings indicated in Claim (1), are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours.
    Type: Grant
    Filed: July 24, 2006
    Date of Patent: February 16, 2010
    Assignee: Merck Patent GmbH
    Inventors: Guenter Hoelzemann, Helene Crassier, Wilfried Rautenberg
  • Pyridopyrimidinones
    Patent number: 7547695
    Abstract: The invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and X? have the designations cited in patent claim 1. Said compounds are inhibitors of tyrosine kinases, especially TIE-2, and Raf kinases, and can, inter alia, be used for the treatment of tumors.
    Type: Grant
    Filed: October 14, 2004
    Date of Patent: June 16, 2009
    Assignee: Merck Patent GmbH
    Inventors: Guenter Hoelzemann, Helene Crassier, Karl-August Ackermann, Wolfgang Staehle, Alfred Jonczyk, Wilfried Rautenberg, Francesc Mitjans, Elisabet Rosell-Vives, Jaume Adan, Marta Soler Riera
  • Sulfonamides
    Patent number: 7528139
    Abstract: Compounds of the formula (I), in which R6, R7, R8, R9 and X have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours.
    Type: Grant
    Filed: March 17, 2005
    Date of Patent: May 5, 2009
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Guenter Hoelzemann, Helene Crassier, Alfred Jonczyk, Wolfgang Staehle, Wilfried Rautenberg
  • Indol derivatives and their use as 5-HT ligands
    Patent number: 7482465
    Abstract: The invention relates to indol derivatives of Formula (I) in which R1, R2, R3, X, A, n, m and p have the meanings indicated above.
    Type: Grant
    Filed: November 17, 2003
    Date of Patent: January 27, 2009
    Assignee: Merck Patent GmbH
    Inventors: Günter Hölzemann, Helene Crassier, Henning Böttcher, Timo Heinrich, Kai Schiemann, Joachim Leibrock, Chrisoph Van Amsterdam, Gerd Bartoszyk, Christoph Seyfried
  • Purine Derivatives as Inhibitors of Receptor Tyrosine Kinase Activity
    Publication number: 20080214582
    Abstract: Compounds of the formula (I), in which R1, R2, R3, R4 and X have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours.
    Type: Application
    Filed: March 15, 2006
    Publication date: September 4, 2008
    Inventors: Guenter Hoelzemann, Helene Crassier, Wilfried Rautenberg, Alfred Jonczyk
  • Pyrazole Derivatives Having Tyrosine Kinase Activity
    Publication number: 20080207647
    Abstract: Compounds of the formula (I), in which R, X, R1, R2, R3 and R4 have the meanings indicated in Claim (1), are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours.
    Type: Application
    Filed: July 24, 2006
    Publication date: August 28, 2008
    Applicant: Merck Patent GmbH
    Inventors: Guenter Hoelzemann, Helene Crassier, Wilfried Rautenberg
  • Pyrazole Derivatives
    Publication number: 20080207699
    Abstract: Compounds of the formula (I), in which R1 and R2 have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases, and can be employed, inter alia, for the treatment of tumours.
    Type: Application
    Filed: March 8, 2006
    Publication date: August 28, 2008
    Applicant: MERCK PATENT GMBH
    Inventors: Guenter Hoelzemann, Helene Crassier, Wilfried Rautenberg
  • Process for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl) piperazin-1-yl)-methanone and salts thereof
    Patent number: 7312342
    Abstract: The present invention relates to a process for the preparation of (3-cyano-1H-indol-7-yl)[4-(4-fluorophenethyl)piperazin-1-yl]-methanone and salts thereof, characterised in that an indole ester of the formula II in which R is as defined in Claim 1, is converter into 3-cyano-1H-indole-7-carboxylic acid via steps (1) to (4) according to Claim 1, and this is reacted with 1-[2-(4-fluorophenyl)ethyl]piperazine of salts thereof to give the product.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: December 25, 2007
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Helene Crassier, Uwe Eckert, Henning Boettcher, Andreas Bathe, Steffen Emmert
  • N,N'-Diphenylurea Derivatives Suitable as Kinase Inhibitors
    Publication number: 20070293488
    Abstract: Compounds of the formula (I), in which R1, R3 and X have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours.
    Type: Application
    Filed: October 12, 2005
    Publication date: December 20, 2007
    Applicant: Merck Patent Gmbh
    Inventors: Guenter Hoelzemann, Helene Crassier, Alfred Jonczyk, Wilfried Rautenberg
  • Sulfonamides
    Publication number: 20070244135
    Abstract: Compounds of the formula (I), in which R6, R7, R8, R9 and X have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours.
    Type: Application
    Filed: March 17, 2005
    Publication date: October 18, 2007
    Inventors: Guenter Hoelzemann, Helene Crassier, Alfred Jonczyk, Wolfgang Staehle, Wilfried Rautenberg
  • Imidazole Derivatives
    Publication number: 20070225347
    Abstract: Compounds of the formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, X and X? have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours.
    Type: Application
    Filed: March 15, 2005
    Publication date: September 27, 2007
    Applicant: Merck Patent GmbH
    Inventors: Guenter Hoelzemann, Helene Crassier, Alfred Jonczyk, Wolfgang Staehle, Arne Sutter, Wilfried Rautenberg, Francesc Mitjans, Elisabet Rosell-Vives, Jaume Adan, Marta Riera
  • Pyridopyrimidinones
    Publication number: 20070099910
    Abstract: The invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and X? have the designations cited in patent claim 1. Said compounds are inhibitors of tyrosine kinases, especially TIE-2, and Raf kinases, and can, inter alia, be used for the treatment of tumours.
    Type: Application
    Filed: October 14, 2004
    Publication date: May 3, 2007
    Applicant: Merck Patent GmbH
    Inventors: Guenter Hoelzemann, Helene Crassier, Karl-August Ackermann, Wolfgang Staehle, Alfred Jonczyk, Wilfried Rautenberg, Francesc Mitjans, Elisabet Rosell-Vives, Jaume Adan, Marta Soler Riera
  • Aminobenzimidazole derivatives
    Publication number: 20070021456
    Abstract: Novel compounds of formula (I) are disclosed, where R1, R1?, L, Y, m and p have the meanings given in claim 1, which are inhibitors of tyrosine kinases, in particular, TIE-2 and Raf kinases and can be used for the treatment of tumors.
    Type: Application
    Filed: July 19, 2004
    Publication date: January 25, 2007
    Applicant: MERCK PATENT GMBH
    Inventors: Francesc Mitjans, Elisabet Rosel-Vives, Jaume Adan, Marta Soler, Guenter Hoelzemann, Helene Crassier, Karl-August Ackermann, Wolfgang Staehle, Alfred Jonczyk, Wilfried Rautenberg
  • Indol derivatives and their use as 5-ht ligands
    Publication number: 20060116405
    Abstract: The invention relates to indol derivatives of Formula (I) in which R1, R2, R3, X, A, n, m and p have the meanings indicated above.
    Type: Application
    Filed: November 17, 2003
    Publication date: June 1, 2006
    Inventors: Gunter Hoelzemann, Helene Crassier, Henning Bottcher, Timo Heinrich, Kai Schiemann, Joachim Leibrock, Chrisoph Van Amsterdam, Gerd Bartoszyk, Christoph Seyfried
  • Process for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl) piperazin-1-yl)- methanone and salts thereof
    Publication number: 20040063723
    Abstract: The present invention relates to a process for the preparation of(3-cyano-1H-indol-7-yl)[4-(4-fluorophenethyl)piperazin-1-yl]-methanone and salts thereof, characterised in that an indole ester of the formula II in which R is as defined in Claim 1, is converter into 3-cyano-1H-indole-7-carboxylic acid via steps (1) to (4) according to Claim 1, and this is reacted with 1-[2-(4-fluorophenyl)ethyl]piperazine of salts thereof to give the product.
    Type: Application
    Filed: July 23, 2003
    Publication date: April 1, 2004
    Inventors: Helene Crassier, Uwe Eckert, Henning Bottcher, Andreas Bathe, Steffen Emmert