Patents by Inventor Helga Woehrer

Helga Woehrer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND DEVICES FOR PRODUCING BIOMOLECULES
    Publication number: 20130331560
    Abstract: A scalable process and device for producing a biomolecule, in particular pharmaceutical grade plasmid DNA. The process includes the steps of alkaline lysis and a neutralization. For separating the lysate and the precipitate, the mixture is allowed to gently flow downward through a clarification reactor that is partially filled, in its lower part, with retention material like glass beads, whereby the precipitate is retained on top of and within the retention. In a preferred embodiment of the lysis step, cell suspension and alkaline lysis solution flow through a lysis reactor that is filled with particulate material like glass beads. The process can be run continuously and fully automated.
    Type: Application
    Filed: June 24, 2013
    Publication date: December 12, 2013
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Jochen URTHALER, Roman NECINA, Christine ASCHER, Helga WOEHRER
  • Methods and devices for producing biomolecules
    Patent number: 8501402
    Abstract: A scalable process and device for producing a biomolecule, in particular pharmaceutical grade plasmid DNA. The process includes the steps of alkaline lysis and a neutralization. For separating the lysate and the precipitate, the mixture is allowed to gently flow downward through a clarification reactor that is partially filled, in its lower part, with retention material like glass beads, whereby the precipitate is retained on top of and within the retention. In a preferred embodiment of the lysis step, cell suspension and alkaline lysis solution flow through a lysis reactor that is filled with particulate material like glass beads. The process can be run continuously and fully automated.
    Type: Grant
    Filed: March 23, 2004
    Date of Patent: August 6, 2013
    Assignee: Boehringer Ingelheim RCV GmbH & Co KG
    Inventors: Jochen Urthaler, Roman Necina, Christine Ascher, Helga Woehrer
  • Methods and devices for producing biomolecules
    Publication number: 20050026177
    Abstract: A scalable process and device for producing a biomolecule, in particular pharmaceutical grade plasmid DNA. The process includes the steps of alkaline lysis and a neutralization. For separating the lysate and the precipitate, the mixture is allowed to gently flow downward through a clarification reactor that is partially filled, in its lower part, with retention material like glass beads, whereby the precipitate is retained on top of and within the retention. In a preferred embodiment of the lysis step, cell suspension and alkaline lysis solution flow through a lysis reactor that is filled with particulate material like glass beads. The process can be run continuosly and fully automated.
    Type: Application
    Filed: March 23, 2004
    Publication date: February 3, 2005
    Applicant: Boehringer Ingelheim Austria GmbH
    Inventors: Jochen Urthaler, Roman Necina, Christine Ascher, Helga Woehrer