Patents by Inventor Helmut Brod
Helmut Brod has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11597901Abstract: Disclosed herein is a sterilizable adapter for a cell culture vessel comprising a body, an upper connection and/or a lid, at least one port, a ventilation passage, a lower internal connection suitable for connection to a cell culture vessel and a cell retention device and/or a cell separation device as well as a device comprising said sterilizable adapter and a method for cell cultivation using said sterilizable adapter.Type: GrantFiled: July 19, 2017Date of Patent: March 7, 2023Assignees: Bayer Aktiengesellschaft, BAYER HEALTHCARE LLCInventors: Annette Eidt, Wolf Kloeckner, Helmut Brod, Martin Poggel, Bernd Tscheschke
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Publication number: 20210277346Abstract: Disclosed herein is a sterilizable adapter for a cell culture vessel comprising a body, an upper connection and/or a lid, at least one port, a ventilation passage, a lower internal connection suitable for connection to a cell culture vessel and a cell retention device and/or a cell separation device as well as a device comprising said sterilizable adapter and a method for cell cultivation using said sterilizable adapter.Type: ApplicationFiled: July 19, 2017Publication date: September 9, 2021Inventors: Annette EIDT, Wolf KLOECKNER, Helmut BROD, Martin POGGEL, Bernd TSCHESCHKE
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Publication number: 20210071131Abstract: What is described herein relates to a prechamber for an inclined channel gravity cell separator with a multitude of channels for retaining cells from a reactor mixture, wherein said prechamber comprises at least one inlet for flow distribution of an incoming fluid stream and at least one aperture towards the multitude of channels and wherein said prechamber encloses a 3-dimensional space.Type: ApplicationFiled: April 17, 2019Publication date: March 11, 2021Inventors: Marc JENNE, Helmut BROD, Joerg KAULING, Helge MOEBUS
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Patent number: 9840691Abstract: The invention relates to the use of single- or multilayer plastic web plates in a sloped channel-type solid material separator with a lamella package.Type: GrantFiled: February 20, 2013Date of Patent: December 12, 2017Assignee: BAYER AKTIENGESELLSCHAFTInventors: Andre Pastor, Juri Seletzky, Helmut Brod, Joerg Kauling, Peter Commer
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Patent number: 9809792Abstract: The invention relates to a separator for retaining and recirculating cells in a continuous-flow or batch-flow type plastic bag or bottle, which can preferably be operated outside of a bioreactor. Additionally, the invention relates to a method for retaining and recirculating cells within or outside a bioreactor. The invention further relates to a method for producing the separator according to the invention.Type: GrantFiled: February 20, 2013Date of Patent: November 7, 2017Assignee: BAYER AKTIENGESELLSCHAFTInventors: Joerg Kauling, Juri Seletzky, Jorgen Magnus, Andre Pastor, Helmut Brod
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Publication number: 20150218501Abstract: The invention relates to a reactor tank designed as a disposable element having a cover and/or sensor patches readable opto-electronically fixed in the interior, a reactor comprising the reactor tank and reactor tank receiving peripherals, the same comprising a reactor tank holder and optionally an opto-electronic measuring system for reading sensor patches, wherein the reactor tank holder is coupled to a drive unit for generating a rotating-oscillation motion of the reactor tank around the central vertical axis thereof, and also the use of this device for culturing cells and/or microorganisms.Type: ApplicationFiled: September 13, 2013Publication date: August 6, 2015Applicant: BAYER TECHNOLOGY SERVICES GMBHInventors: Joerg Kauling, Annette Waldhelm, Helmut Brod, Verena Herrmann, Stefanie Jacob
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Publication number: 20150024478Abstract: The invention relates to the use of single- or multilayer plastic web plates in a sloped channel-type solid material separator with a lamella package.Type: ApplicationFiled: February 20, 2013Publication date: January 22, 2015Applicants: BAYER TECHNOLOGY SERVICES GMBh, MAYER INTELLECTUAL PROPERTY GMBHInventors: Andre Pastor, Juri Seletzky, Helmut Brod, Joerg Kauling, Peter Commer
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Publication number: 20150017716Abstract: The invention relates to a separator for retaining and recirculating cells in a continuous-flow or batch-flow type plastic bag or bottle, which can preferably be operated outside of a bioreactor. Additionally, the invention relates to a method for retaining and recirculating cells within or outside a bioreactor. The invention further relates to a method for producing the separator according to the invention.Type: ApplicationFiled: February 20, 2013Publication date: January 15, 2015Inventors: Joerg Kauling, Juri Seletzky, Jorgen Magnus, Andre Pastor, Helmut Brod
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Publication number: 20140293734Abstract: The invention relates to a reactor driven in an oscillatory-rotary manner about its fixed, preferably vertical, axis, for preferably biotechnological and pharmaceutical applications. By means of its process-intensifying properties for mixing, suspension, gaseous material transport, heat transfer, irradiation and particle retention, the applicability on the industrial scale is ensured. The reactor which succeeds without a shaft seal permits particularly robust production with respect to sterile technique with avoidance of cleaning and cleaning validation required when the reactor is constructed as a single-use reactor.Type: ApplicationFiled: May 15, 2014Publication date: October 2, 2014Inventors: Jörg KAULING, Helmut BROD, Sebastian SCHMIDT, Martin POGGEL, Björn FRAHM, Reinhold ROSE
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Publication number: 20140080213Abstract: The invention relates to a reactor driven in an oscillatory-rotary manner about its fixed, preferably vertical, axis, for preferably biotechnological and pharmaceutical applications. By means of its process-intensifying properties for mixing, suspension, gaseous material transport, heat transfer, irradiation and particle retention, the applicability on the industrial scale is ensured. The reactor which succeeds without a shaft seal permits particularly robust production with respect to sterile technique with avoidance of cleaning and cleaning validation required when the reactor is constructed as a single-use reactor.Type: ApplicationFiled: October 7, 2013Publication date: March 20, 2014Inventors: Jörg KAULING, Helmut BROD, Sebastian SCHMIDT, Martin POGGEL, Björn FRAHM, Reinhold ROSE
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Patent number: 8602636Abstract: The invention relates to a reactor driven in an oscillatory-rotary manner about its fixed, preferably vertical, axis, for preferably biotechnological and pharmaceutical applications. By means of its process-intensifying properties for mixing, suspension, gaseous material transport, heat transfer, irradiation and particle retention, the applicability on the industrial scale is ensured. The reactor which succeeds without a shaft seal permits particularly robust production with respect to sterile technique with avoidance of cleaning and cleaning validation required when the reactor is constructed as a single-use reactor.Type: GrantFiled: April 23, 2007Date of Patent: December 10, 2013Assignee: Bayer Intellectual Property GmbHInventors: Jörg Kauling, Helmut Brod, Sebastian Schmidt, Martin Poggel, Björn Frahm, Reinhold Rose
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Patent number: 8328167Abstract: The present invention relates to a device for the aeration of liquid media by tube aeration, special tube modules contained therein and the use of a device for the aeration of liquid media.Type: GrantFiled: October 25, 2006Date of Patent: December 11, 2012Assignee: Bayer Technology Services GmbHInventors: Jörg Kauling, Hans-Jürgen Henzler, Sebastian Schmidt, Helmut Brod, Klaus Kaiser, Stephan Kirchner, Dirk Havekost
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Publication number: 20120282677Abstract: The invention relates to a photobioreactor having illumination by light sources (light guides, LEDs) moved in rotational oscillation, and optionally membrane surfaces for gas transport moved in combination in rotational oscillation. Advantages are, inter alia, light input which is spatially homogeneous on average over time and can be adapted by means of intensity and oscillation to the culture and its density, as well as low-shear power input and optionally low-shear bubble free gasification and degassing.Type: ApplicationFiled: May 2, 2012Publication date: November 8, 2012Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventors: Helmut BROD, Bjoern FRAHM
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Publication number: 20120234394Abstract: The invention relates to a sparger for introducing a gas or gas mixture into a liquid and to a method for sparging liquids. The sparger according to the invention comprises a cavity, a gas inlet for routing a gas into the cavity and two or more faces, which are or can be pressed onto one another in a positive fashion such that a gas pressed into the cavity through the gas inlet escapes through the gaps occurring between the pressed together faces.Type: ApplicationFiled: September 4, 2010Publication date: September 20, 2012Applicant: BAYER TECHNOLOGY SERVICES GMBHInventors: Jurl Seletzky, Joerg Kauling, Björn Frahm, Helmut Brod, Marc Jenne, Franz Schmitt
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Publication number: 20110256624Abstract: The invention relates to a bioreactor, to the use of the bioreactor for culturing microorganisms or cell cultures, and also to a method for culturing microorganisms or cell cultures.Type: ApplicationFiled: December 8, 2009Publication date: October 20, 2011Applicant: BAYER TECHNOLOGY SERVICES GMBHInventors: Marc Jenne, Björn Frahm, Joerg Kauling, Helmut Brod
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Publication number: 20110165677Abstract: The invention relates to a process for reducing the amount of deposits during the culture of organisms, and in particular of cell cultures, where these have a tendency towards agglomeration or adhesion to the bioreactor and to its elements, or where these are readily susceptible to agglomeration or adhesion of cell debris or of substances.Type: ApplicationFiled: September 17, 2009Publication date: July 7, 2011Applicant: Bayer Technology Services GMBHInventors: Helmut Brod, Björn Frahm, Joerg Kauling
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Publication number: 20110097800Abstract: The invention relates to a device and a method for retaining and recirculating cells in a vessel through which flow passes continuously or batchwise. In addition, the invention relates to a method of producing a device by which cells can be retained and recirculated in a vessel through which flow passes continuously or batchwise.Type: ApplicationFiled: June 10, 2009Publication date: April 28, 2011Applicant: Bayer Technology Services GmbhInventors: Joerg Kauling, Björn Frahm, Marc Jenne, Helmut Brod, Stephan Kirchner, Arndt Braun
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Patent number: 7871193Abstract: A mixer having improved axial and radial mixing which retains good mixing time even during large viscosity changes, comprising a housing with at least one helical or anchor agitator located centrally in the housing in combination with at least one eccentrically arranged screw or blade agitator, preferably in mutual engagement, the combination of a helical agitator and a screw agitator enabling a much shorter mixing time as compared to a mixer having only a helical agitator without a screw agitator.Type: GrantFiled: July 2, 2005Date of Patent: January 18, 2011Assignee: Bayer Technology Services GmbHInventors: Helmut Brod, Stefanie Köhler, Reinhold Rose
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Publication number: 20090286318Abstract: The present invention relates to a device for the aeration of liquid media by means of tube aeration, special tube modules contained therein and the use of a device for the aeration of liquid media.Type: ApplicationFiled: October 25, 2006Publication date: November 19, 2009Inventors: Jörg Kauling, Hans-Jürgen Henzler, Sebastian Schmidt, Helmut Brod, Klaus Kaiser, Stephan Kirchner, Dirk Havekost
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Publication number: 20090180933Abstract: The invention relates to a reactor driven in an oscillatory-rotary manner about its fixed, preferably vertical, axis, for preferably biotechnological and pharmaceutical applications. By means of its process-intensifying properties for mixing, suspension, gaseous material transport, heat transfer, irradiation and particle retention, the applicability on the industrial scale is ensured. The reactor which succeeds without a shaft seal permits particularly robust production with respect to sterile technique with avoidance of cleaning and cleaning validation required when the reactor is constructed as a single-use reactor.Type: ApplicationFiled: April 23, 2007Publication date: July 16, 2009Applicant: Bayer Technology Services GmbHInventors: Jörg Kauling, Helmut Brod, Sebastian Schmidt, Martin Poggel, Björn Frahm, Reinhold Rose