Patents by Inventor Helmut MAECKE

Helmut MAECKE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BOMBESIN ANALOG PEPTIDE ANTAGONIST CONJUGATES
    Publication number: 20150265733
    Abstract: To provide a diagnostic and therapeutic medicament, a bombesin analog peptide antagonist conjugate is provided which has general Formula (I), wherein A is a metal chelator comprising at least one radionuclide metal, B is a spacer linked to N-terminal of C or a covalent bond and C is a bombesin analog peptide antagonist having a sequence as claimed, where further x is an Integer from 1 to 3 and n is an integer from 1 to 6.
    Type: Application
    Filed: March 27, 2015
    Publication date: September 24, 2015
    Applicants: UNIVERSITÄT BERN, UNIVERSITÄTSSPITAL BERN
    Inventors: Helmut MAECKE, Jean Claude REUBI, Rosalba MANSI
  • Bombesin analog peptide antagonist conjugates
    Patent number: 9035023
    Abstract: To provide a diagnostic and therapeutic medicament, a bombesin analog peptide antagonist conjugate is provided which has general Formula (I), wherein A is a metal chelator comprising at least one radionuclide metal, B is a spacer linked to N-terminal of C or a covalent bond and C is a bombesin analog peptide antagonist having a sequence as claimed, where further x is an integer from 1 to 3 and n is an integer from 1 to 6.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: May 19, 2015
    Assignee: Piramal Imaging, SA
    Inventors: Helmut Maecke, Jean Claude Reubi, Rosalba Mansi
  • Bombesin Analog Peptide Antagonist Conjugates
    Publication number: 20110097266
    Abstract: To provide a diagnostic and therapeutic medicament, a bombesin analog peptide antagonist conjugate is provided which has general Formula (I), wherein A is a metal chelator comprising at least one radionuclide metal, B is a spacer linked to N-terminal of C or a covalent bond and C is a bombesin analog peptide antagonist having a sequence as claimed, where further x is an integer from 1 to 3 and n is an integer from 1 to 6.
    Type: Application
    Filed: February 27, 2009
    Publication date: April 28, 2011
    Inventors: Helmut Maecke, Jean Claude Reubi, Rosalba Mansi
  • TREATMENT PROCESS USING SOMATOSTATIN ANALOGUES
    Publication number: 20070154392
    Abstract: In one embodiment, a method for treating a cancerous disease is provided which includes characterizing a disease by an overexpression of one or more somatostatin receptors, and exposing the one or more somatostatin receptors to a pharmaceutical composition comprising a somatostatin analogue which binds to the one or more somatostatin receptors.
    Type: Application
    Filed: March 8, 2007
    Publication date: July 5, 2007
    Inventors: Helmut Maecke, Jean Reubi, Hans Rink, Klaus-Peter Eisenwiener
  • Prochelator for the preparation of radiometal labeled molecules having improved biological properties
    Publication number: 20060233704
    Abstract: Chelating compounds for labeling bioactive molecules with a radiometal, having general formula (I) in which: both Y groups may be positioned either trans as shown or cis; A is an effector molecule, such as a peptide, in particular octreotide, CCK, substance P, gastrine, a protein, in particular an antibody or enzyme, sugars or radiosensitizing agents, like doxorubicin; R is a hydrogen, a C1-C3 alkyl or a alcohol; X is a spacer, in particular (CH2)n—X?, in which n is 1-10 and X? is COOH, NH2, SH, OH or O-halogen, in which halogen is in particular Br, I or Cl, or a molecule of the formula (a) or of the formula (b), Y is COO—, CH2CONH2, CH2CH2OH, optionally complexed with a radiometal.
    Type: Application
    Filed: May 11, 2001
    Publication date: October 19, 2006
    Inventors: Helmut MAECKE, Klaus-Peter EISENWIENER