Patents by Inventor Helmut Merkle

Helmut Merkle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11684306
    Abstract: This disclosure generally relates to stable water isotope labeling followed by detection via MRI (swiMRI), including deuterium MRI (dMRI) and 17O MRI, for visualizing rapidly dividing immune cells within target and/or lymphoid organ/s and/or tissues affected by chronic graft-versus-host disease (cGVHD). Using deuterated water labeling, followed by dMRI, a distinction in deuterium signal was detected in a target organ (e.g. liver) of the cGVHD-affected mice compared to unaffected mice, i.e. syngeneic HSCT recipient mice, where the host and donor are matched, and normal (unmanipulated) mice.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: June 27, 2023
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES et al.
    Inventors: Nataliya Buxbaum, Donald Farthing, Martin Lizak, Helmut Merkle, Natella Maglakelidze, Brittany Oliver, Ronald Gress
  • Publication number: 20190274616
    Abstract: This disclosure generally relates to stable water isotope labeling followed by detection via MRI (swiMRI), including deuterium MRI (dMRI) and 17O MRI, for visualizing rapidly dividing immune cells within target and/or lymphoid organ/s and/or tissues affected by chronic graft-versus-host disease (cGVHD). Using deuterated water labeling, followed by dMRI, a distinction in deuterium signal was detected in a target organ (e.g. liver) of the cGVHD-affected mice compared to unaffected mice, i.e. syngeneic HSCT recipient mice, where the host and donor are matched, and normal (unmanipulated) mice.
    Type: Application
    Filed: October 27, 2017
    Publication date: September 12, 2019
    Inventors: Nataliya BUXBAUM, Donald FARTHING, Martin LIZAK, Helmut MERKLE, Natella MAGLAKELIDZE, Brittany OLIVER, Ronald GRESS
  • Patent number: 5965047
    Abstract: A rapid thermal processing (RTP) chamber, wherein one wall of the chamber supporting a substrate rotates with respect to the rest of the chamber so that the substrate being treated in the RTP chamber is relatively rotated with respect to the lamps heating the substrate.
    Type: Grant
    Filed: October 24, 1997
    Date of Patent: October 12, 1999
    Assignee: Steag AST
    Inventors: Werner Blersch, Peter Gruenwald, Michael Maurer, Helmut Merkle, Thomas Theiler, Heinrich Walk
  • Patent number: 5870526
    Abstract: A rapid thermal processing (RTP) chamber is disclosed, wherein a transparent plate and a body are sealed with a gas tight seal, and wherein the gas tight seal is activated by inflating an inflatable element.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: February 9, 1999
    Assignee: Steag-Ast
    Inventors: Helmut Aschner, Helmut Merkle, Ulrich Walk, Dieter Zernickel
  • Patent number: 5580830
    Abstract: A reaction chamber for a Rapid Thermal Processing (RTP) system contains an aperture to allow introduction and removal of the object to be processed. The cross sectional area of the aperture is significantly less than the cross sectional area of the reaction chamber. A method of flushing the reaction chamber, using a short time laminar flow of the flush gas, is used in combination with the aperture to increase the throughput of the RTP system.
    Type: Grant
    Filed: February 13, 1995
    Date of Patent: December 3, 1996
    Assignee: AST Elekronik
    Inventors: Zsolt Nenyei, Helmut Merkle, Andreas Tillmann
  • Patent number: 4079262
    Abstract: A mobile current consumer device, especially a fire control device for artillery- and/or rocket weapons, comprising a current generator unit insertable into a receiving compartment thereof. In the installed condition of the current generator unit, at least two spatially separated cooling air currents can be delivered to the current generator unit, and removed in the form of heated air currents spatially separated from one another. The one cooling air current can be delivered to an internal combustion engine of the current consumer device provided with a blower by means of an air infeed channel having a suction opening facing in the direction of travel. Such air current is then removable as heated air from the cooling casing surrounding the engine through the floor of the current generator unit which is extensively open at the region of the engine and by means of at least one opening provided in the floor of the receiving compartment.
    Type: Grant
    Filed: November 15, 1976
    Date of Patent: March 14, 1978
    Assignee: Contraves AG
    Inventor: Helmut Merkle