Abstract: A cooking appliance comprises an outer frame surface defining a cooktop and the cooktop defines an outlet port. An inner frame surface defines a heating cavity disposed below the cooktop and within the outer frame surface. The inner frame surface defines an inlet port and a chimney extends between a first end connected to the inlet port and a second end connected to the outlet port for directing steam from the heating cavity outside of the cooking appliance. A nozzle apparatus is connected around the outlet port and includes an inner wall defining at least one aperture. The at least one aperture is oriented at an acute angle relative to the cooktop. The nozzle apparatus includes at least one post for connection to the cooktop.

Abstract: Provided herein are populations of placental-derived natural killer cells comprising a cleavage resistant CD16. Also provided are methods of treating diseases, disorders or conditions in a human subject comprising administering to the subject an effective amount of a population of placental-derived natural killer cells comprising a cleavage resistant CD16 to the subject so as thereby to provide an effective treatment of the to the subject. The cells, such as CYNK cells, can be placental CD34+ cell-derived natural killer (NK) cells. The diseases, disorders or conditions include cancers such as multiple myeloma and lymphoma. The present invention also provides compositions comprising populations of placental-derived natural killer cells comprising a cleavage resistant CD16 for the treatment of a subject and methods of their use.

Abstract: A system, method, and computer program product for setting an employee contribution to a retirement plan are disclosed. The method includes: assigning, by a computer system, each employee in a plurality of employees to one of a plurality of clusters by processing socio-economic information for the plurality of employees using machine learning to generate a machine learning model; determining, by the computer system, a benchmark for each cluster in the plurality of clusters from a characteristic of contributions to a retirement plan of the employees assigned to the cluster; identifying, by the computer system, a selected cluster in the plurality of clusters for a selected employee using the machine learning model; and controlling displaying, by a graphical user interface, the benchmark for the selected cluster to the selected employee.

Abstract: A dry granulation process using a twin-screw extruder for granulating a powder mixture which includes at least one active ingredient and at least one carrier. The process includes steps of kneading the powder mixture in the screw barrel of the twin-screw extruder at a barrel temperature below a melting point of the at least one active ingredient and a melting point or a glass transition temperature of the at least one carrier to provide a kneaded powder mixture, and extruding the kneaded powder mixture to form granules. Granules and tablets produced using the dry granulation process in the twin-screw extruder are also provided.

Abstract: A dry granulation process using a twin-screw extruder for granulating a powder mixture which includes at least one active ingredient and at least one carrier. The process includes steps of kneading the powder mixture in the screw barrel of the twin-screw extruder at a barrel temperature below a melting point of the at least one active ingredient and a melting point or a glass transition temperature of the at least one carrier to provide a kneaded powder mixture, and extruding the kneaded powder mixture to form granules. Granules and tablets produced using the dry granulation process in the twin-screw extruder are also provided.

Abstract: Provided herein are methods of treating cancer in a human subject comprising administering to the subject an effective amount of human placental-derived natural killer cells comprising a CD38 chimeric antigen receptor (CAR) to the subject so as thereby to provide an effective treatment of the cancer in the subject. The cells, such as CYNK cells, can be placental CD34+ cell-derived natural killer (NK) cells. The cancers to be treated include multiple myeloma and lymphoma. The present invention also provides compositions comprising human placental-derived natural killer cells comprising a CD38 chimeric antigen receptor (CAR) or the treatment of multiple myeloma and lymphoma and methods of their use.

Abstract: The present invention relates to a stable liquid pharmaceutical composition of pemetrexed for parenteral administration. The invention provides composition comprising pemetrexed diacid, an organic amine and cyclodextrin. The composition may further comprise an inert gas. The composition can be ready to use infusion solution of pemetrexed diacid or liquid concentrate formulation to be diluted before administration to the patient. The present invention further relates to a process for manufacturing the compositions as well as use of the compositions of the invention for the treatment of malignant pleural mesothelioma and non-small cell lung cancer.

Abstract: A diabetes management system includes a handheld medical device, a mobile computing device, and a diabetes management application. The handheld medical device is configured to measure glucose in a sample of fluid residing in a test strip and associate a measurement time with the glucose measurement. The diabetes management application is configured to request a current device time from the RTC, determine a first device delta time by determining a difference between the current device time and an internal clock time, and associate a first timestamp with a glucose measurement, wherein the first timestamp is equal to the measurement time plus the first device delta time.

Abstract: Provided herein are stimulated placental stem cells and methods of treating individuals having diseases or disorders of the circulatory system using stimulated placental cells. The invention also provides methods of inducing angiogenesis using such stimulated cells or populations of cells comprising such stimulated cells.

Abstract: A video player that can launch a program from the video player while a video relating to the program (for example, a tutorial video) is being played. Also, a video player that can start a video location at a time location that is determined by a program location currently being executed by a computer program being run by the user. In order to do these things, a mapping is maintained between time ranges in the video and program locations to which the time ranges of the video respectively relate.

Abstract: To increase the efficiency of electronic design automation, in a putative electronic logic circuit design, at least one transparent latch is identified as a candidate for slack stealing. An initial timing slack, available for stealing, and associated with the at least one transparent latch, is determined. Responsive to a determination that the initial timing slack available for stealing is insufficient, it is determined whether the initial timing slack available for stealing is on a feedback path. If so, responsive to determining that the initial timing slack available for stealing is on the feedback path, the initial timing slack available for stealing is replaced with a next worse slack.

Abstract: To increase the efficiency of electronic design automation, in a putative electronic logic circuit design, at least one transparent latch is identified as a candidate for slack stealing. An initial timing slack, available for stealing, and associated with the at least one transparent latch, is determined. Responsive to a determination that the initial timing slack available for stealing is insufficient, it is determined whether the initial timing slack available for stealing is on a feedback path. If so, responsive to determining that the initial timing slack available for stealing is on the feedback path, the initial timing slack available for stealing is replaced with a next worse slack.

Abstract: A dissimilar query engine is configured to translate a query including a first query language to a second query language. One dissimilar query engine includes a configuration script handler configured to retrieve at least one pair of query language configuration scripts, a uniform query language compiler configured to translate the first query language to a uniform query language using the at least one pair of query language configuration scripts, and a uniform query language interpreter configured to translate the uniform query language to the second query language using the at least one pair of query language configuration scripts.

Abstract: A dry granulation process using a twin-screw extruder for granulating a powder mixture which includes at least one active ingredient and at least one carrier. The process includes steps of kneading the powder mixture in the screw barrel of the twin-screw extruder at a barrel temperature below a melting point of the at least one active ingredient and a melting point or a glass transition temperature of the at least one carrier to provide a kneaded powder mixture, and extruding the kneaded powder mixture to form granules. Granules and tablets produced using the dry granulation process in the twin-screw extruder are also provided.

Abstract: A dry granulation process using a twin-screw extruder for granulating a powder mixture which includes at least one active ingredient and at least one carrier. The process includes steps of kneading the powder mixture in the screw barrel of the twin-screw extruder at a barrel temperature below a melting point of the at least one active ingredient and a melting point or a glass transition temperature of the at least one carrier to provide a kneaded powder mixture, and extruding the kneaded powder mixture to form granules. Granules and tablets produced using the dry granulation process in the twin-screw extruder are also provided.

Abstract: The present invention relates to a stable liquid pharmaceutical composition of pemetrexed for parenteral administration. The invention provides composition comprising pemetrexed diacid, an organic amine and cyclodextrin. The composition may further comprise an inert gas. The composition can be ready to use infusion solution of pemetrexed diacid or liquid concentrate formulation to be diluted before administration to the patient. The present invention further relates to a process for manufacturing the compositions as well as use of the compositions of the invention for the treatment of malignant pleural mesothelioma and non-small cell lung cancer.

Abstract: A method for a processing circuit to display a graphical user interface (GUI) for a building management system (BMS). The method includes retrieving structured data from a display service executed by the processing circuit, wherein the structured data is a library. The method further includes generating a tag based on the structured data, wherein the tag associates interface data and bound data from a number of different data sources. The interface data describing an arrangement of an element of the GUI, and the bound data describing content of the element. The bound data is associated with the element according to the arrangement. The interface data and bound data are selected by a user. The method further includes displaying, on a display of a client device, the GUI based on the tag. The GUI may be used in different formats by associating the interface data with a different one of bound data, or the bound data with a different one of the interface data.

Abstract: A video player that can launch a program from the video player while a video relating to the program (for example, a tutorial video) is being played. Also, a video player that can start a video location at a time location that is determined by a program location currently being executed by a computer program being run by the user. In order to do these things, a mapping is maintained between time ranges in the video and program locations to which the time ranges of the video respectively relate.

Abstract: A method, system and computer readable media are provided to generate short video notes (v-notes) from one or more videos. A series of inputs including playback commands from a user is received. By utilizing a machine learning system, the received inputs can be analyzed for video content to identify which portions are of importance. A customized v-note, smaller in size than the one or more videos, may be generated by aggregating the identified portions of video content from the one or more videos, wherein the v-note is customized to the user, based upon received inputs from the user.

Abstract: A system and method involves partitioning a design of an integrated circuit into two or more hierarchical levels. A lowest level includes macros and a higher level includes some or all of the macros. Each of the macros includes two or more components. A macro timing model corresponding with each of the macros indicates a delay through the macro. The macro timing model corresponding with ones of the macros that are part of the higher level are loaded to perform higher-level timing analysis, which indicates a delay through the ones of the macros that are part of the higher level. Modified macro timing models corresponding with one or more of the macros are generated, and only the modified macro timing models associated with the macros that are part of the higher level modify corresponding loaded macro timing models to continue the higher-level timing analysis.