Patents by Inventor Henderik W. Frijlink

Henderik W. Frijlink has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ion-strength independent sustained release pharmaceutical formulation
    Patent number: 8034379
    Abstract: The present invention is related to an optionally coated pharmaceutical hydrophilic gel forming matrix formulation comprising one or more active substances and having a prolonged release of said one or more active substances upon exposure to gastrointestinal fluids, characterized in that said release is substantially ion-strength independent. The invention is further related to a method of preparing this formulation which can be used in the administration of active substances for the treatment of a large number of disorders.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: October 11, 2011
    Assignee: Solvay Pharmaceuticals B.V.
    Inventors: Henricus R. M. Gorissen, Henderik W. Frijlink
  • Stabilized difloxacin injectable solution
    Patent number: 7273870
    Abstract: An antibacterial formulation suitable for injection into animals containing approximately 2-10% w/v difloxacin HCl, L-arginine base, propylene glycol, ethanol and/or benzyl alcohol, and water. The formulation is a solution having a pH of form 9 to 10. The formulation produces little or no tissue damage or irritation at the injection site.
    Type: Grant
    Filed: March 3, 2005
    Date of Patent: September 25, 2007
    Assignee: Wyeth
    Inventor: Henderik W. Frijlink
  • Stabilized difloxacin injectable solution
    Patent number: 6872723
    Abstract: An antibacterial formulation suitable for injection into animals containing approximately 2-10% w/v difloxacin HCl, L-arginine base, propylene glycol, ethanol and/or benzyl alcohol, and water. The formulation is a solution having a pH of form 9 to 10. The formulation produces little or no tissue damage or irritation at the injection site.
    Type: Grant
    Filed: January 17, 2003
    Date of Patent: March 29, 2005
    Assignee: Wyeth
    Inventor: Henderik W. Frijlink
  • Ion-strength independent sustained release pharmaceutical formulation
    Publication number: 20040013727
    Abstract: The present invention is related to an optionally coated pharmaceutical hydrophilic gel foaming matrix formulation comprising one or more active substances and having a prolonged release of said one or more active substances upon exposure to gastrointestinal fluids, characterized in that said release is substantially ion-strength independent. The invention is further related to a method of preparing this formulation which can be used in the administration of active substances for the treatment of a large number of disorders.
    Type: Application
    Filed: March 28, 2003
    Publication date: January 22, 2004
    Inventors: Henricus R. M. Gorissen, Henderik W. Frijlink
  • Stabilized natural cannabinoid formulation
    Publication number: 20030229027
    Abstract: The present invention is related to a pharmaceutical composition comprising a natural cannabinoid compound, for example, &Dgr;9-tetrahydrocannabinol, and a glass of a sugar, sugar alcohol, mixture of sugars or mixture of sugar alcohols, characterized in that the natural cannabinoid compound is incorporated in the sugar glass as a monomolecular encapsulation without formation of a guest-host complex. The invention further relates to a method for the preparation of the pharmaceutical composition in the form of a sugar glass by freeze drying, spray drying, vacuum drying, or critical drying of a stable mixture containing the natural cannabinoid compound and a sugar or a mixture of sugars.
    Type: Application
    Filed: April 2, 2003
    Publication date: December 11, 2003
    Inventors: Anko C. Eissens, Dirk Jan Van Drooge, Woulter L.J. Hinrichs, Henderik W. Frijlink
  • Stabilized difloxacin injectable solution
    Publication number: 20030153581
    Abstract: An antibacterial formulation suitable for injection into animals containing approximately 2-10% w/v difloxacin HCI, L-arginine base, propylene glycol, ethanol and/or benzyl alcohol, and water. The formulation is a solution having a pH of form 9 to 10. The formulation produces little or no tissue damage or irritation at the injection site.
    Type: Application
    Filed: January 17, 2003
    Publication date: August 14, 2003
    Applicant: Wyeth
    Inventor: Henderik W. Frijlink
  • Oral delayed immediate release formulation and method for preparing the same
    Patent number: 6183780
    Abstract: The invention relates to an Oral Delayed Immediate Release formulation comprising a compressed core containing one or more active substances surrounded with a coating, wherein release of active substance from the core is caused by rupture of the coating after a definite lag-time, said core comprising one or more immediate release carriers and having no substantial swelling properties upon exposure to gastrointestinal fluids. The invention further relates to formulations containing an Immediate Release formulation combined with one or more Oral Delayed Immediate Release formulations with different lag-times and to a method of preparing an Oral Delayed Immediate Release formulation.
    Type: Grant
    Filed: September 19, 1997
    Date of Patent: February 6, 2001
    Assignee: Duphar International Research B.V.
    Inventors: Paulus M. Van Balken, Jules A. C. Elbers, Henderik W. Frijlink, Wienman E. Philips