Abstract: Disclosed is a system and method for in-situ and instantaneous measurement of a pressure gradient by real-time localized pressure measurement with two or more pressure sensors, operating with respect to blood pressure gradient across the aortic valve, or other heart valves, and associated regurgitation of blood flow due to leakage resulting from insufficient valve closure. The system includes a multi-sensor catheter, with sensors arranged along the length of the distal segment of the catheter body, spaced apart to provide simultaneous pressure measurement on either side of the valves of the heart, in addition to one or more lumina in the core of the catheter that will provide a path for introduction of diagnostic fluids which flow out through a multitude of holes in the body of the distal segment of the catheter body.

Abstract: Disclosed is a system and method for in-situ and instantaneous measurement of a pressure gradient by means of real-time localized pressure measurement with two or more pressure sensors, operating under particular application with respect to blood pressure gradient across the aortic valve, or other heart valves, and associated regurgitation of blood flow due to leakage resulting from insufficient valve closure. The pressure gradient across a diseased valve can provide an indication for the clinical indication for therapeutic intervention, as well as performing quality control following prosthetic valve placement. The body can have a construction including at least one opening in communication with the fluid bed of the circulation of blood, connected by means of a fluid canal passing the length of the catheter in contact with the proximal exterior space for introduction of a guidewire, diagnostic fluid or other therapeutic or diagnostic catheter devices.