Patents by Inventor Hendrik Jan Ankersmit

Hendrik Jan Ankersmit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230000910
    Abstract: The present invention relates to a composition comprising a supernatant of a peripheral blood mononuclear cell (PBMC) cell culture for use in the treatment or prevention of an allergy or an allergic reaction caused by the administration of at least one food and/or inhalation allergen or by the systemic administration of at least one drug to a human or mammal body.
    Type: Application
    Filed: December 23, 2020
    Publication date: January 5, 2023
    Inventors: Hendrik Jan Ankersmit, Michael Mildner
  • Patent number: 11333662
    Abstract: The present invention relates to a method for determining the potency of a supernatant of a mammalian cell culture to be used in the treatment of an inflammatory condition.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: May 17, 2022
    Assignee: APOSCIENCE AG
    Inventors: Hendrik Jan Ankersmit, Michael Mildner
  • Publication number: 20220118020
    Abstract: The present invention relates to a topical pharmaceutical preparation for treating an inflammatory skin condition, preferably a condition associated with ischemia, comprising a supernatant of a physiological solution obtainable by cultivating peripheral blood mononuclear cells (PBMCs) or a subset thereof in a physiological solution free of PBMC-proliferating and PBMC-activating substances for at least 1 h.
    Type: Application
    Filed: December 20, 2021
    Publication date: April 21, 2022
    Inventor: Hendrik Jan Ankersmit
  • Patent number: 11235003
    Abstract: The present invention relates to a topical pharmaceutical preparation for treating an inflammatory skin condition, preferably a condition associated with ischemia, comprising a supernatant of a physiological solution obtainable by cultivating peripheral blood mononuclear cells (PBMCs) or a subset thereof in a physiological solution free of PBMC-proliferating and PBMC-activating substances for at least 1 h.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: February 1, 2022
    Assignee: APOSCIENCE AG
    Inventor: Hendrik Jan Ankersmit
  • Publication number: 20200386740
    Abstract: The present invention relates to a method for determining the potency of a supernatant of a mammalian cell culture to be used in the treatment of an inflammatory condition.
    Type: Application
    Filed: December 19, 2018
    Publication date: December 10, 2020
    Inventors: Hendrik Jan ANKERSMIT, Michael MILDNER
  • Publication number: 20200254019
    Abstract: The present invention relates to a pharmaceutical preparation for treating an inflammatory condition, preferably a condition associated with ischemia comprising: a) a physiological solution comprising peripheral blood mononuclear cells (PBM-Cs) or a subset thereof, or b) a supernatant of the solution a), wherein the solution a) is obtainable by cultivating PBMCs or a subset thereof in a physiological solution free of PBMC-proliferating and PBMC-activating substances for at least 1 h.
    Type: Application
    Filed: November 18, 2019
    Publication date: August 13, 2020
    Inventor: Hendrik Jan Ankersmit
  • Patent number: 10478456
    Abstract: The present invention relates to a pharmaceutical preparation for treating an inflammatory condition, preferably a condition associated with ischemia comprising: a) a physiological solution comprising peripheral blood mononuclear cells (PBM-Cs) or a subset thereof, or b) a supernatant of the solution a), wherein the solution a) is obtainable by cultivating PBMCs or a subset thereof in a physiological solution free of PBMC-proliferating and PBMC-activating substances for at least 1 h.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: November 19, 2019
    Assignee: APOSCIENCE AG
    Inventor: Hendrik Jan Ankersmit
  • Publication number: 20130244260
    Abstract: The present invention relates to a method for discriminating between early and advanced stage lung carcinoma in an individual suffering from lung carcinoma comprising the steps of a) providing a sample of an individual suffering from lung carcinoma, b) determining the level of heat shock protein 27 (HSP27) in said sample, c) comparing the determined level of HSP27 in said sample with a reference range of HSP27 measured in samples of control individuals with an early stage lung carcinoma and/or with advanced stage lung carcinoma, d) diagnosing early stage lung carcinoma in said individual when the level of HSP27 in sample a) is below the reference range of HSP27 in samples of control individuals with advanced stage lung carcinoma or within the reference range of control individuals with early stage lung carcinoma and diagnosing advanced stage lung carcinoma when the level of HSP27 in sample a) is above the reference range of HSP27 in samples of control individuals with early stage lung carcinoma or within the
    Type: Application
    Filed: December 14, 2011
    Publication date: September 19, 2013
    Applicant: Aposcience AG
    Inventor: Hendrik Jan Ankersmit
  • Publication number: 20120045418
    Abstract: The present invention relates to a topical pharmaceutical preparation for treating an inflammatory skin condition, preferably a condition associated with ischemia, comprising a supernatant of a physiological solution obtainable by cultivating peripheral blood mononuclear cells (PBMCs) or a subset thereof in a physiological solution free of PBMC-proliferating and PBMC-activating substances for at least 1 h.
    Type: Application
    Filed: December 18, 2009
    Publication date: February 23, 2012
    Applicant: APOSCIENCE AG
    Inventor: Hendrik Jan Ankersmit
  • Publication number: 20110250190
    Abstract: The present invention relates to a pharmaceutical preparation for treating an inflammatory condition, preferably a condition associated with ischemia comprising: a) a physiological solution comprising peripheral blood mononuclear cells (PBM-Cs) or a subset thereof, or b) a supernatant of the solution a), wherein the solution a) is obtainable by cultivating PBMCs or a subset thereof in a physiological solution free of PBMC-proliferating and PBMC-activating substances for at least 1 h.
    Type: Application
    Filed: December 18, 2009
    Publication date: October 13, 2011
    Applicant: APOSCIENCE AG
    Inventor: Hendrik Jan Ankersmit
  • Publication number: 20090098104
    Abstract: Method for diagnosing a cardiovascular disease in an individual comprising the steps of: providing a sample of an individual; determining the amount of cytokeratin-18 (CK-18) or fragments thereof and/or interleukin-1? precursor (IL-1? precursor) in said sample; comparing the amount of CK-18 or fragments thereof and/or IL-1? precursor in said sample to the amount of CK-18 or fragments thereof and/or IL-1? precursor present in a reference control of at least one individual not suffering from a cardiovascular disease; and diagnosing a cardiovascular disease if the amount of CK-18 or fragments thereof in the sample is increased in comparison to the amount of CK-18 or fragments thereof in the reference control and/or the amount of IL-1? precursor in the sample is decreased in comparison to the amount of IL-1? precursor in the reference control.
    Type: Application
    Filed: April 16, 2007
    Publication date: April 16, 2009
    Applicant: MEDIZINISCHE UNIVERSITAT WIEN
    Inventor: Hendrik Jan Ankersmit
  • Patent number: 5669216
    Abstract: A process for the continuous conversion of energy chemically bound in a starting fuel based on C-H compounds into usable mechanical energy. For this purpose, a gas turbine is used and in order to obtain high mechanical efficiency the combustion is effected at least partially with a fuel obtained from the starting fuel by endothermic reaction, the heating of the reaction space for the endothermic reaction being effected either by compressed combustion air, which has been heated by the exhaust gases, or by the hot exhaust gas itself.
    Type: Grant
    Filed: April 3, 1995
    Date of Patent: September 23, 1997
    Assignee: Mannesmann Aktiengesellschaft
    Inventors: Hendrik Jan Ankersmit, Rudolf Hendriks, Leo Jozef Maria Joannes Blomen