Patents by Inventor Hendrik Marinus van Rossum

Hendrik Marinus van Rossum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENOME EDITING USING CRISPR IN CORYNEBACTERIUM
    Publication number: 20230074594
    Abstract: A CRISPR system is successfully used to modify the genomes of a gram-positive bacterium, such as a species of the Cornybacterium genus. Methods for modifying Corynebacterium species include single-nucleotide changes, creating gene deletions and/or insertions.
    Type: Application
    Filed: August 3, 2022
    Publication date: March 9, 2023
    Inventors: Stephen BLASKOWSKI, Robert COATES, Kedar PATEL, Hendrik Marinus VAN ROSSUM, Shawn SZYJKA
  • MODULAR UNIVERSAL PLASMID DESIGN STRATEGY FOR THE ASSEMBLY AND EDITING OF MULTIPLE DNA CONSTRUCTS FOR MULTIPLE HOSTS
    Publication number: 20210371856
    Abstract: Methods, compositions, and kits for high throughput DNA assembly reactions in vitro. Modular CRISPR DNA constructs comprising modular insert DNA parts flanked by cloning tag segments comprising pre-validated CRISPR protospacer/protospacer adjacent motif sequence combinations.
    Type: Application
    Filed: August 3, 2021
    Publication date: December 2, 2021
    Inventors: Brian CHAIKIND, Hendrik Marinus VAN ROSSUM
  • Modular universal plasmid design strategy for the assembly and editing of multiple DNA constructs for multiple hosts
    Patent number: 11098305
    Abstract: Methods, compositions, and kits for high throughput DNA assembly reactions in vitro. Modular CRISPR DNA constructs comprising modular insert DNA parts flanked by cloning tag segments comprising pre-validated CRISPR protospacer/protospacer adjacent motif sequence combinations.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: August 24, 2021
    Assignee: Zymergen Inc.
    Inventors: Brian Chaikind, Hendrik Marinus van Rossum
  • GENOME EDITING USING CRISPR IN CORYNEBACTERIUM
    Publication number: 20200362346
    Abstract: A CRISPR system is successfully used to modify the genomes of a gram-positive bacterium, such as a species of the Corynebacterium genus. Methods for modifying Corynebacterium species include single-nucleotide changes, creating gene deletions and/or insertions.
    Type: Application
    Filed: July 30, 2020
    Publication date: November 19, 2020
    Inventors: Stephen BLASKOWSKI, Robert COATES, Kedar PATEL, Hendrik Marinus VAN ROSSUM, Shawn SZYJKA
  • MODULAR UNIVERSAL PLASMID DESIGN STRATEGY FOR THE ASSEMBLY AND EDITING OF MULTIPLE DNA CONSTRUCTS FOR MULTIPLE HOSTS
    Publication number: 20200123540
    Abstract: The disclosure describes methods, compositions, and kits for high throughput DNA assembly reactions in vitro. The disclosure further describes modular CRISPR DNA constructs comprising modular insert DNA parts flanked by cloning tag segments comprising pre-validated CRISPR protospacer/protospacer adjacent motif sequence combinations.
    Type: Application
    Filed: August 8, 2019
    Publication date: April 23, 2020
    Inventors: Brian Chaikind, Hendrik Marinus van Rossum
  • SCARLESS DNA ASSEMBLY AND GENOME EDITING USING CRISPR/CPF1 AND DNA LIGASE
    Publication number: 20190330659
    Abstract: The disclosure describes a scarless DNA assembly and genome editing methodology termed “CLIC” (CRISPR and Ligase Cloning), which utilizes a CRISPR/Cpf1 complex and DNA ligase to perform programmable gene editing and nucleotide assembly. The CLIC process is highly amenable to applications in vitro for the scarless assembly of a plurality of DNA parts simultaneously or in vivo for the site-specific insertion of one or more DNA molecules into the host genome.
    Type: Application
    Filed: July 14, 2017
    Publication date: October 31, 2019
    Inventors: William C. DeLoache, Hendrik Marinus van Rossum, Kedar Gautam Patel