Patents by Inventor Henning Von Horsten

Henning Von Horsten has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for preparation of fucose-linked site specific conjugates of proteins with toxins, adjuvants, detection labels and pharmacokinetic half life extenders
    Patent number: 9765158
    Abstract: The present invention relates to eukaryotic cells for producing molecules having an atypical fucose analog on their glycomoieties and/or amino acids. It also relates to methods for producing molecules having an atypical fucose analog on their glycomoieties and/or amino acids and to molecules obtainable by said methods. It further relates to methods for producing conjugates comprising molecules having an atypical fucose analog on their glycomoieties and/or amino acids and pharmaceutical active compounds and to conjugates obtainable by said methods. In addition, the present invention relates to specific conjugates.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: September 19, 2017
    Assignee: Probiogen AG
    Inventors: Hans Henning Von Horsten, Volker Sandig, Ingo Jordan, Karsten Winkler
  • Enhancement of protein production yield mediated by a fast shuttling CDC42 GTPase
    Patent number: 9163089
    Abstract: The present invention relates to a cell for producing a secreted protein comprising a polynucleotide comprising a nucleic acid sequence encoding a fast cycling cdc42 mutant and a polynucleotide comprising a nucleic acid sequence encoding a secreted protein. It also relates to a method for producing said cell and to a method for producing a secreted protein using said cell.
    Type: Grant
    Filed: May 14, 2012
    Date of Patent: October 20, 2015
    Assignee: Probiogen AG
    Inventors: Volker Sandig, Karsten Winkler, Henning Von Horsten, Thomas Rose
  • ENHANCEMENT OF PROTEIN PRODUCTION YIELD MEDIATED BY A FAST SHUTTLING CDC42 GTPASE
    Publication number: 20140377803
    Abstract: The present invention relates to a cell for producing a secreted protein comprising a polynucleotide comprising a nucleic acid sequence encoding a fast cycling cdc42 mutant and a polynucleotide comprising a nucleic acid sequence encoding a secreted protein. It also relates to a method for producing said cell and to a method for producing a secreted protein using said cell.
    Type: Application
    Filed: May 14, 2012
    Publication date: December 25, 2014
    Applicant: PROBIOGEN AG
    Inventors: Volker Sandig, Karsten Winkler, Henning Von Horsten, Thomas Rose
  • METHODS FOR PREPARATION OF FUCOSE-LINKED SITE SPECIFIC CONJUGATES OF PROTEINS WITH TOXINS, ADJUVANTS, DETECTION LABELS AND PHARMACOKINETIC HALF LIFE EXTENDERS
    Publication number: 20140221627
    Abstract: The present invention relates to eukaryotic cells for producing molecules having an atypical fucose analogue on their glycomoieties and/or amino acids. It also relates to methods for producing molecules having an atypical fucose analogue on their glycomoieties and/or amino acids and to molecules obtainable by said methods. It further relates to methods for producing conjugates comprising molecules having an atypical fucose analogue on their glycomoieties and/or amino acids and pharmaceutical active compounds and to conjugates obtainable by said methods. In addition, the present invention relates to specific conjugates.
    Type: Application
    Filed: May 31, 2012
    Publication date: August 7, 2014
    Applicant: ProBioGen AG
    Inventors: Hans Henning Von Horsten, Volker Sandig, INgo Jordan, Karsten Winkler
  • Process for producing molecules containing specialized glycan structures
    Patent number: 8642292
    Abstract: The present invention relates to cells for producing a molecule lacking fucose, having a reduced amount of fucose, or having other atypical sugars on its glycomoieties. It also relates to methods for producing a molecule lacking fucose, having a reduced amount of fucose, or having other atypical sugars on its glycomoieties using said cells and to molecules obtainable by said methods. The present invention further relates to molecules having an artificial glycosylation pattern.
    Type: Grant
    Filed: September 21, 2010
    Date of Patent: February 4, 2014
    Assignee: Probiogen AG
    Inventors: Volker Sandig, Hans Henning von Horsten, Christiane Ogorek
  • AAD-1 EVENT DAS-40278-9, RELATED TRANSGENIC CORN LINES, AND EVENT-SPECIFIC IDENTIFICATION THEREOF
    Publication number: 20120214975
    Abstract: The present invention relates to cells for producing a molecule lacking fucose, having a reduced amount of fucose, or having other atypical sugars on its glycomoieties. It also relates to methods for producing a molecule lacking fucose, having a reduced amount of fucose, or having other atypical sugars on its glycomoieties using said cells and to molecules obtainable by said methods. The present invention further relates to molecules having an artificial glycosylation pattern.
    Type: Application
    Filed: September 21, 2010
    Publication date: August 23, 2012
    Inventors: Volker Sandig, Hans Henning Von Horsten, Christiane Ogorek