Abstract: A spray drying apparatus has a spray drying chamber; a liquid feed atomizer; a drying gas disperser; a perforated bottom; and a plenum chamber with an outlet below the perforated bottom. At least one guide plate is provided in the plenum chamber to direct gas, which is passing through the perforated bottom into the plenum chamber, towards the bottom of the plenum chamber. The guide plates have lower edges extending on average down to at least half-way between the perforated bottom of the spray drying chamber and the bottom of the plenum chamber.

Abstract: A method for training an operator of a spray drying plant, the spray drying plant including a plurality of plant elements including pre-processing elements, a spray drying element, post-processing elements, powder recovery elements, and a programmable logic controller, PLC. The method including the steps of: obtaining a transient model of the spray drying plant, wherein the transient model includes transient sub-models of the plurality of plant elements; calculating repeatedly simulated sensor data based on the obtained transient model, using a processing unit; displaying on a display a training human machine interface, tHMI, configured to communicate with the transient model of the spray drying plant, and to display the simulated sensor data and control data for the transient model; and updating the transient model based on operator input on the tHMI, for controlling the transient model of the spray drying plant.

Abstract: A spray drying apparatus has a spray drying chamber; a liquid feed atomizer; a drying gas disperser; a perforated bottom; and a plenum chamber with an outlet below the perforated bottom. At least one guide plate is provided in the plenum chamber to direct gas, which is passing through the perforated bottom into the plenum chamber, towards the bottom of the plenum chamber. The guide plates have lower edges extending on average down to at least half-way between the perforated bottom of the spray drying chamber and the bottom of the plenum chamber.

Abstract: The invention relates to a plant for production of tablets, a process for production of tablets and tablets as such. The plant comprises a mixing device producing a mixed liquid feed of active pharmaceutical ingredient and excipients. A spray dryer atomizes the mixed liquid feed and dried particles with a high flowability are produced. The dried particles are subsequently compressed to tablets in a tablet press. The invention possesses several advantages, including the possibility of using an auto mated rotary tablet press directly, thereby reducing the number of unit operations in the tablet production.