Patents by Inventor Henry B. Lowman

Henry B. Lowman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMMUNOGLOBULIN VARIANTS AND USES THEREOF
    Publication number: 20220002430
    Abstract: The invention provides humanized and chimeric anti-CD20 antibodies for treatment of CD20 positive malignancies and autoimmune diseases.
    Type: Application
    Filed: April 20, 2021
    Publication date: January 6, 2022
    Applicant: Genentech, Inc.
    Inventors: Camellia W. ADAMS, Andrew C. CHAN, Craig W. CROWLEY, Henry B. LOWMAN, Gerald R. NAKAMURA, Leonard G. PRESTA
  • IMMUNOGLOBULIN VARIANTS AND USES THEREOF
    Publication number: 20210002359
    Abstract: Variant immunoglobulins with one or more amino acid modifications in the Fe region that have increased in vivo half-lives, and methods of using the same are provided.
    Type: Application
    Filed: June 1, 2020
    Publication date: January 7, 2021
    Applicant: Genentech, Inc.
    Inventors: Henry B. LOWMAN, Yik Andy YEUNG, Lisa A. DAMICO, Napaleone FERRARA, Yu-Ju G. MENG
  • ANTIBODY VARIANTS
    Publication number: 20190202902
    Abstract: Antibody variants of parent antibodies are disclosed which have one or more amino acids inserted in a hypervariable region of the parent antibody and a binding affinity for a target antigen which is at least about two fold stronger than the binding affinity of the parent antibody for the antigen.
    Type: Application
    Filed: July 13, 2018
    Publication date: July 4, 2019
    Applicant: Genentech, Inc.
    Inventors: Yvonne M. Chen, Henry B. Lowman, Yves Muller
  • IMMUNOGLOBULIN VARIANTS WITH ALTERED BINDING TO PROTEIN A
    Publication number: 20190085094
    Abstract: Variant immunoglobulins with one or more amino acid modifications in the VH region that have altered binding to Staphylococcus aureus protein A, and methods of using the same are provided.
    Type: Application
    Filed: November 16, 2018
    Publication date: March 21, 2019
    Applicant: Genentech, Inc.
    Inventors: Yik Andy Yeung, Henry B. Lowman
  • IMMUNOGLOBULIN VARIANTS AND USES THEREOF
    Publication number: 20190071511
    Abstract: The invention provides humanized and chimeric anti-CD20 antibodies for treatment of CD20 positive malignancies and autoimmune diseases.
    Type: Application
    Filed: February 26, 2018
    Publication date: March 7, 2019
    Applicant: Genentech, Inc.
    Inventors: Camellia W. ADAMS, Andrew C. CHAN, Craig W. CROWLEY, Henry B. LOWMAN, Gerald R. NAKAMURA, Leonard G. PRESTA
  • ANTI-HER2 ANTIBODY VARIANTS
    Publication number: 20180201692
    Abstract: The present invention concerns novel antibody variants, particularly anti-HER2 antibody variants having substitutions at positions within the variable domains of the heavy and light chains
    Type: Application
    Filed: October 10, 2017
    Publication date: July 19, 2018
    Inventors: Henry B. Lowman, Resi B. Gerstner, Paul J. Carter
  • ANTI-VEGF ANTIBODIES
    Publication number: 20170369564
    Abstract: Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
    Type: Application
    Filed: January 15, 2016
    Publication date: December 28, 2017
    Applicant: Genentech, Inc.
    Inventors: Manuel Baca, James A. Wells, Leonard G. Presta, Henry B. Lowman, Yvonne Man-yee Chen
  • ANTI-HER2 ANTIBODY VARIANTS
    Publication number: 20170166656
    Abstract: The present invention concerns novel antibody variants, particularly anti-HER2 antibody variants having substitutions at positions within the variable domains of the heavy and light chains
    Type: Application
    Filed: February 27, 2017
    Publication date: June 15, 2017
    Inventors: Henry B. Lowman, Resi B. Gerstner, Paul J. Carter
  • HUMANIZED ANTI-FACTOR D ANTIBODIES AND USES THEREOF
    Publication number: 20170166630
    Abstract: The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
    Type: Application
    Filed: July 29, 2016
    Publication date: June 15, 2017
    Inventors: Ling-Ling An, Sek Chung Fung, Robert F. Kelley, Henry B. Lowman, Sanjaya Singh, Herren Wu
  • IMMUNOGLOBULIN VARIANTS AND USES THEREOF
    Publication number: 20170158773
    Abstract: The invention provides humanized and chimeric anti-CD20 antibodies for treatment of CD20 positive malignancies and autoimmune diseases.
    Type: Application
    Filed: July 22, 2016
    Publication date: June 8, 2017
    Inventors: Camellia W. ADAMS, Andrew C. CHAN, Craig W. CROWLEY, Henry B. LOWMAN, Gerald R. NAKAMURA, Leonard G. PRESTA
  • ANTIBODY VARIANTS
    Publication number: 20170096480
    Abstract: Antibody variants of parent antibodies are disclosed which have one or more amino acids inserted in a hypervariable region of the parent antibody and a binding affinity for a target antigen which is at least about two fold stronger than the binding affinity of the parent antibody for the antigen.
    Type: Application
    Filed: December 20, 2016
    Publication date: April 6, 2017
    Applicant: Genentech, Inc.
    Inventors: Yvonne M. Chen, Henry B. Lowman, Yves Muller
  • IMMUNOGLOBULIN VARIANTS WITH ALTERED BINDING TO PROTEIN A
    Publication number: 20160369007
    Abstract: Variant immunoglobulins with one or more amino acid modifications in the VH region that have altered binding to Staphylococcus aureus protein A, and methods of using the same are provided.
    Type: Application
    Filed: May 19, 2016
    Publication date: December 22, 2016
    Applicant: Genentech, Inc.
    Inventors: Yik Andy Yeung, Henry B. Lowman
  • ANTI-VEGF ANTIBODIES
    Publication number: 20160257738
    Abstract: Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
    Type: Application
    Filed: October 6, 2015
    Publication date: September 8, 2016
    Applicant: GENENTECH, INC.
    Inventors: Manuel Baca, James A. Wells, Leonard G. Presta, Henry B. Lowman, Yvonne Man-Yee Chen
  • Assays for detecting antibodies specific to therapeutic anti-IgE antibodies and their use in anaphylaxis
    Patent number: 9315583
    Abstract: The invention provides methods and reagents useful for detecting anti-drug antibodies of IgE isotype to therapeutic anti-IgE antibodies, and methods for assessing risk of anaphylaxis to administration of a therapeutic anti-IgE antibody.
    Type: Grant
    Filed: October 26, 2010
    Date of Patent: April 19, 2016
    Assignee: Genentech, Inc.
    Inventors: Saloumeh Fischer, Dana L. Baker, Henry B. Lowman, Gerald R. Nakamura
  • ANTI-HER2 ANTIBODY VARIANTS
    Publication number: 20160060353
    Abstract: The present invention concerns novel antibody variants, particularly anti-HER2 antibody variants having substitutions at positions within the variable domains of the heavy and light chains
    Type: Application
    Filed: September 18, 2014
    Publication date: March 3, 2016
    Applicant: GENENTECH, INC.
    Inventors: Henry B. LOWMAN, Resi B. GERSTNER, Paul J. CARTER
  • Humanized Anti-Factor D Antibodies And Uses Thereof
    Publication number: 20160002352
    Abstract: The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
    Type: Application
    Filed: July 6, 2015
    Publication date: January 7, 2016
    Inventors: Ling-Ling An, Sek Chung Fung, Robert F. Kelley, Henry B. Lowman, Sanjaya Singh, Herren Wu
  • Humanized Anti-Factor D Antibodies And Uses Thereof
    Publication number: 20160002353
    Abstract: The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
    Type: Application
    Filed: July 6, 2015
    Publication date: January 7, 2016
    Inventors: Ling-Ling An, Sek Chung Fung, Robert F. Kelley, Henry B. Lowman, Sanjaya Singh, Herren Wu
  • Humanized Anti-Factor D Antibodies And Uses Thereof
    Publication number: 20150376295
    Abstract: The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
    Type: Application
    Filed: July 6, 2015
    Publication date: December 31, 2015
    Inventors: Ling-Ling An, Sek Chung Fung, Robert F. Kelley, Henry B. Lowman, Sanjaya Singh, Herren Wu
  • ANTIBODY VARIANTS
    Publication number: 20150284458
    Abstract: Antibody variants of parent antibodies are disclosed which have one or more amino acids inserted in a hypervariable region of the parent antibody and a binding affinity for a target antigen which is at least about two fold stronger than the binding affinity of the parent antibody for the antigen.
    Type: Application
    Filed: June 18, 2015
    Publication date: October 8, 2015
    Applicant: GENENTECH, INC.
    Inventors: Yvonne M. CHEN, Henry B. LOWMAN, Yves MULLER
  • ANTI-VEGF ANTIBODIES
    Publication number: 20150023951
    Abstract: Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
    Type: Application
    Filed: February 3, 2014
    Publication date: January 22, 2015
    Applicant: Genentech, Inc.
    Inventors: Manuel Baca, James A. Wells, Leonard G. Presta, Henry B. Lowman, Yvonne Man-yee Chen