Abstract: An oral appliance rejuvenation system can restore an oral appliance placed therein by removing stresses arising from wear. In embodiments of the invention, the oral appliance rejuvenation system includes a sanitation or cleaning module, active ingredient loading module, annealing module, and a sensor module to monitor compliance and optionally, detect analyte information originating from oral appliances stored in the appliance holder. The appliance holder communicates with a server that is configured to process the information generated by the system. The analyte information can be processed to develop a wellness profile. Related methods are also described.

Abstract: Orthodontic intervention is performed after a patient, undergoing an orthodontic treatment plan utilizing orthodontic aligners, sends an image of their teeth remotely to an image processing module. The image is analyzed to determine current teeth position and crate an electronic model of the current teeth position. From the teeth position model, it is determined that the current teeth position is not compatible with the orthodontic treatment plan, which typically requires restarting the treatment plan and having the patient rescanned. Here, an electronic model of a rescue appliance is generated, where the rescue aligner is configured to move the teeth to a position back into compatibility with the orthodontic aligners. The rescue aligner is manufactured and sent to the patient without requiring the patient to visit any point of care.

Abstract: In certain aspects, devices and methods for an oral appliance holder that can detect analyte information originating from oral appliances stored in the appliance holder. The analyte information can be derived from found in volatilized compounds detected within the appliance holder. The appliance holder can directly or indirectly communicate with a server that is configured to process the analyte information. The analyte information can be processed to develop a wellness profile.