Patents by Inventor Henry J. Doran

Henry J. Doran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process of synthesis of a tricyclic ketone intermediate
    Patent number: 6608202
    Abstract: In one embodiment, the present invention describes the synthesis of a compound of Formula III, wherein X is halogen, and intermediates therefor from easily available starting materials by a simple route.
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: August 19, 2003
    Assignee: Schering Corporation
    Inventors: Henry J. Doran, Pat M. O'Neill, Robert P. Williams
  • PROCESS OF SYNTHESIS OF A TRICYCLIC KETONE INTERMEDIATE
    Publication number: 20030144314
    Abstract: In one embodiment, the present invention describes the synthesis of a compound of Formula III, wherein X is halogen, 1
    Type: Application
    Filed: August 20, 2002
    Publication date: July 31, 2003
    Applicant: Schering Corporation
    Inventors: Henry J. Doran, Pat M. O'Neill, Robert P. Williams
  • Process for preparing tricyclic compounds having antihistaminic activity
    Patent number: 6271378
    Abstract: Disclosed is a process for preparing a compound having the formula: wherein R1 is selected from the group consisting of: alkyl, alkenyl, alkynyl, aryl, aralkyl, cycloalkyl, and cycloalkylalkyl, R1 being optionally substituted by substituents selected from halo, —OH, alkyl, alkoxy, or —CF3, said process comprising the following steps: (a) reacting a ketone having the formula with a carbanion having the formula wherein R1 is as defined above, and R2 and R3 are independently selected from the group consisting of —ORA and —RA, wherein RA is alkyl, phenyl, substituted phenyl, cycloalkyl, substituted cycloalkyl, cycloalkylalkyl, or substituted cycloalkylalkyl; (b) treating the reaction mixture from step (a) with a protonating agent; and (c) thermally decomposing the product of 16, to form the compound of formula (I). The compounds made by this process have antihistaminic activity, e.g., loratadine.
    Type: Grant
    Filed: December 16, 1999
    Date of Patent: August 7, 2001
    Assignee: Schering Corporation
    Inventors: Henry J. Doran, Pat M. O'Neill
  • Process for preparing flunixin and intermediates thereof
    Patent number: 5965735
    Abstract: Process for preparing a key intermediate, 2-methyl-3-trifluoromethylaniline (MTA) of Flunixin, as well as novel intermediates thereof are described.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: October 12, 1999
    Assignee: Schering Corporation
    Inventors: Henry J. Doran, Donal J. Coveney
  • Process for preparing Flunixin and intermediates thereof
    Patent number: 5484931
    Abstract: Process for preparing a key intermediate, 2-methyl-3-trifluoromethylaniline (MTA) of Flunixin, as well as novel intermediates thereof are described.
    Type: Grant
    Filed: June 15, 1994
    Date of Patent: January 16, 1996
    Assignee: Schering Corporation
    Inventors: Henry J. Doran, Donal J. Coveney
  • Selective catalytic oxidation of unsaturated alcohols to carbonyl compounds
    Patent number: 4225694
    Abstract: Primary and secondary unsaturated alcohols are converted to their corresponding aldehydes and/or carboxylic acids and ketones respectively with alkali metal (per) halate, preferably sodium periodate, in the presence of ruthenium catalyst. The process is particularly useful in the oxidation of chrysanthemyl alcohol. Any unconverted intermediate aldehyde formed may be converted to the acid by recycling or by a separate oxidation step.
    Type: Grant
    Filed: September 6, 1977
    Date of Patent: September 30, 1980
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Augustine I. Dalton, Jr., Henry J. Doran, Robert D. H. Murray