Patents by Inventor Henry J. Rosenfeld

Henry J. Rosenfeld has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In situ nicotinamide coenzyme generating system for enzyme based clinical chemistry assays
    Patent number: 5589348
    Abstract: The invention relates to an improved enzymatic method for determining the concentration of an analyte in a sample body fluid. The improvement comprises a coupled enzyme reaction scheme comprising the in situ generation of reduced nicotinamide coenzyme, with either simultaneous or subsequent re-oxidation of coenzyme by an analyte substrate and substrate specific enzymes. The change in absorbance due to the reoxidation of coenzyme is proportional to the concentration of analyte in the reaction mixture.
    Type: Grant
    Filed: March 22, 1994
    Date of Patent: December 31, 1996
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard A. Kaufman, John M. Konopka, Henry J. Rosenfeld, Janine E. Sabo
  • Enzymatic Reagents for ethanol assay containing diamino compounds
    Patent number: 5525481
    Abstract: An enzymatic assay assemblage for ethanol determination is provided. A diamino compound acts as a buffer and a trapping agent for a product of the enzymatic reaction. Long stability of the assay composition is achieved.
    Type: Grant
    Filed: May 29, 1992
    Date of Patent: June 11, 1996
    Assignee: Hoffman-La Roche Inc.
    Inventors: Richard A. Kaufman, Henry J. Rosenfeld
  • Enzymatic composition for ethanol assay
    Patent number: 5141854
    Abstract: An enzymatic assay composition for ethanol determination is provided. A compound of the formulaH.sub.2 N--(CH.sub.2).sub.n --CHR--CH.sub.2 --NH.sub.2whereR is H, CH.sub.3, or OH andN is 0-4acts as a buffer and a trapping agent for a product of the enzymatic reaction. Long stability of the assay composition is achieved.
    Type: Grant
    Filed: December 13, 1990
    Date of Patent: August 25, 1992
    Assignee: Hoffman-La Roche, Inc.
    Inventors: Richard A. Kaufman, Henry J. Rosenfeld
  • Method and reagent for the quantitative determination of phosphorous in serum and urine
    Patent number: 4826773
    Abstract: A reagent for determining quantitatively the amount of phosphorous in bodily fluids which comprises a surface active agent, a strong acid, ammonium molybdate, a heavy metal chelating compound, and anti-oxidant, and deionized water is described. A method of using such a reagent is also described.
    Type: Grant
    Filed: July 18, 1988
    Date of Patent: May 2, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard A. Kaufman, Henry J. Rosenfeld, Denise Zaunczkowski