Abstract: The memory device includes a memory block with an array of memory cells. The memory device also includes control circuitry that is in communication with the memory cells. The control circuitry is configured to program a group of the memory cells in a programming operation that does not include verify to obtain a natural threshold voltage (nVt) distribution, calculate an nVt width of the nVt distribution, compare the nVt width to a threshold, and identify the memory block as being vulnerable to cross-temperature read errors in response to the nVt width exceeding the threshold.

Abstract: The memory device includes a plurality of dies, and each die includes a plurality of blocks with a plurality of word lines. Some of the word lines are arranged in a plurality of exclusive OR (XOR) sets with each XOR set containing word lines in the same positions across the plurality of dies. The memory device further includes a controller that is configured to program the word lines of the blocks of at least one of the dies in a first programming direction. The controller is further configured to program the word lines of the blocks of at least one other die in a second programming direction that is opposite of the first programming direction.

Abstract: A die including a die body having a first body surface, a second body surface on an opposite side of the die body as the first body surface, an interconnect region adjacent to the first body surface including interconnect dielectric layers with metal lines and vias, a transistor region above the interconnect region, the metal lines and vias making electrical connections to one or more power rails of the transistor region and electrically connected to transistors of the transistor region, a power region above the transistor region including an electro-conductive film on the second body surface and TSVs in the power region, an outer end of the TSV contacting the film and an embedded end of the TSVs contacting one of the power rails. A method of manufacturing an IC package and computer with the IC package are also disclosed.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for updating a molecular database. In one aspect, a method includes: receiving data representing a sequence of molecular nucleotides, where the data specifies a base of each molecular nucleotide and synthetic modifications to one or more components of one or more molecular nucleotides in the sequence; generating a user interface presentation that presents: i) for each base in the sequence, a base character that represents the base of the molecular nucleotide, and ii) for each of the one or more molecular nucleotides having one or more components that are synthetically modified, a group of symbols adjacent to the base character that represents the base of the molecular nucleotide, where each symbol in the group of symbols represents a respective synthetic modification; and providing the user interface presentation to a user device for display to a user.

Abstract: The disclosure provides methods and compositions, e.g., kits, for identifying or authenticating a sample, e.g., a tumor model, based on the genotype of the sample at a group of SNP loci.

Abstract: The disclosure provides methods and compositions, e.g., kits and microarray, for assessing the immune response in a murine tumor model based on the expression of a gene panel that characterizes tumor immune interactions.

Abstract: Methods and apparatus provide filtration for concentrating analytes, such as bacteria or exosomes, of a biological sample, such as blood or urine. The technology may employ membrane devices that implement one or more tangential flow filtration processes such as in stages. An example membrane device may typically include a membrane having sides and ends. The membrane may selectively permit constituent(s) of the sample to pass through while retaining other constituents at one side. An input chamber of the device may include an inlet near one end and an outlet near the other end, and that may permit a tangential flow of the sample along the first side surface, and a trans-membrane passing of constituent(s). An output chamber of the device may be configured at the second side surface to receive the passing constituents. Such devices may be provided in a kit to facilitate targeting of a desired biological analyte concentration.

Abstract: The disclosure provides methods and compositions, e.g., kits, for identifying or authenticating a sample, e.g., a tumor model, based on the genotype of the sample at a group of SNP loci.

Abstract: The present disclosure provides methods of detecting a fusion gene of HNF4G and RSPO2 in a nucleic acid-containing sample, and a primer set, a probe set and a kit for detecting the fusion gene are also provided. Animal models for a human disease positive for the fusion gene are also provided herein. In addition, the present disclosure relates to the methods for assessing and identifying an agent effective on the fusion gene of HNF4G and RSPO2 or a human disease positive for a fusion gene of HNF4G and RSPO2 and thereby treating said disease are also provided.

Abstract: The present disclosure provides methods of detecting a fusion gene of HNF4G and RSPO2 in a nucleic acid-containing sample, and a primer set, a probe set and a kit for detecting the fusion gene are also provided. Animal models for a human disease positive for the fusion gene are also provided herein. In addition, the present disclosure relates to the methods for assessing and identifying an agent effective on the fusion gene of HNF4G and RSPO2 or a human disease positive for a fusion gene of HNF4G and RSPO2 and thereby treating said disease are also provided.

Abstract: A client navigation system establishes a wireless connection to a navigation server on a computer network. The client requests a route by uploading start and destination specifications. The server calculates an optimal route based on real-time data available on the network. A generic natural language description is used to specify the optimal route downloaded to the client. The natural language description is a plain text description for each link using pre-defined generic terms. The client interprets the route, interfaces with the local mapping data and reconstructs the optimal route. The route is subsequently displayed and highlighted on the client.

Abstract: A client navigation system establishes a wireless connection to a navigation server on a computer network. The client requests a route by uploading start and destination specifications. The server calculates an optimal route based on real-time data available on the network. A generic natural language description is used to specify the optimal route downloaded to the client. The natural language description is a plain text description for each link using pre-defined generic terms. The client interprets the route, interfaces with the local mapping data and reconstructs the optimal route. The route is subsequently displayed and highlighted on the client.

Abstract: A client navigation system establishes a wireless connection to a navigation server on a computer network. The client requests a route by uploading start and destination specifications. The server calculates an optimal route based on real-time data available on the network. A generic natural language description is used to specify the optimal route downloaded to the client. The natural language description is a plain text description for each link using pre-defined generic terms. The client interprets the route, interfaces with the local mapping data and reconstructs the optimal route. The route is subsequently displayed and highlighted on the client.

Abstract: A client navigation system establishes a wireless connection to a navigation server on a computer network. The client requests a route by uploading start and destination specifications. The server calculates an optimal route based on real-time data available on the network. A generic natural language description is used to specify the optimal route downloaded to the client. The natural language description is a plain text description for each link using pre-defined generic terms. The client interprets the route, interfaces with the local mapping data and reconstructs the optimal route. The route is subsequently displayed and highlighted on the client.

Abstract: A system and method for virally growing a social network. The social network system receives a member account sign-up message for a first social network from a first member. The social network system then posts a member sign-up notification to the first member's event wall on a second social network; wherein the first member has one or more social contacts through the second social network. For at least a second respective member in the one or more social contacts, the social network system posts a personalized invitation message as a comment to the member sign-up notification on the first member's event wall, wherein the comment is initially hidden from all members other than the second respective member of the one or more member contacts.

Abstract: A client navigation system establishes a wireless connection to a navigation server on a computer network. The client requests a route by uploading start and destination specifications. The server calculates an optimal route based on real-time data available on the network. A generic natural language description is used to specify the optimal route downloaded to the client. The natural language description is a plain text description for each link using pre-defined generic terms. The client interprets the route, interfaces with the local mapping data and reconstructs the optimal route. The route is subsequently displayed and highlighted on the client.

Abstract: A system and method for virally growing a social network. The social network system receives a member account sign-up message for a first social network from a first member. The social network system then posts a member sign-up notification to the first member's event wall on a second social network; wherein the first member has one or more social contacts through the second social network. For at least a second respective member in the one or more social contacts, the social network system posts a personalized invitation message as a comment to the member sign-up notification on the first member's event wall, wherein the comment is initially hidden from all members other than the second respective member of the one or more member contacts.

Abstract: The present teachings relate to methods of screening for a therapeutic agent for human acute myelogenous leukemia (AML) and methods for treating AML. The method includes administering a test substance to an immunocompromised NOD/SCID mouse engrafted with a substance containing a leukemic cell derived from a human AML patient and a step of assessing improvement in leukemia in the mouse and/or to monitor a side effect of the test substance. The method can further include monitoring a side effect of the test substance in the mouse.

Abstract: The present teachings relate to methods of screening for a therapeutic agent, selecting a treatment and monitoring a treatment for a human disease or infection and methods for producing a mouse model for human disease or infection wherein the mouse has a functioning human immune system. The method includes administering a test substance to an immunocompromised NOD/SCID mouse with a reconstituted human immune system and is also engrafted with a substance containing a diseased or infectious cell derived from a human diseased or infected patient and a step of assessing improvement in the disease or infection of the mouse and/or to monitor a side effect of the test substance.

Abstract: Methods and systems for processing Ethernet data are disclosed and may comprise receiving Ethernet data via a single gigabit Ethernet IP telephone chip. A secure application key may be received from a secure server by an OSM integrated within the gigabit Ethernet IP telephone chip for processing the received Ethernet data. The received Ethernet data may be processed by the gigabit Ethernet IP telephone chip based on the received secure application key. A unique security identifier internal to the single gigabit Ethernet IP telephone chip may be communicated off-chip to the secure server. The unique security identifier may identify the single gigabit Ethernet IP telephone chip. The secure server may authenticate the gigabit Ethernet IP telephone chip based on the unique security identifier internal to the single gigabit Ethernet IP telephone chip, prior to the receiving of the secure application key.