Patents by Inventor Henry M. Miziorko

Henry M. Miziorko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-hydroxy-3-methyl-glutaryl-coa synthase preparation with improved stability
    Patent number: 5668001
    Abstract: A preparation of recombinant 3-hydroxy-3-methylglutaryl-CoA synthase is disclosed, wherein the preparation has at least 0.024 unitsg specific activity. Preferably, the preparation has at least 0.24 units/mg specific activity and is a crude cell extract. Preferably, at least 90% of the synthase molecules have not been substantially proteolytically cleaved. A preparation of recombinant HMG-CoA synthase wherein the preparation retains 50% activity after storage at 4.degree. C. for six months is also disclosed. A method of evaluating the efficacy of candidate anti-isoprene and anti-cholesterol drugs is also disclosed which comprises exposing the candidate drug to a recombinant 3-hydroxy-3-methylglutaryl CoA synthase preparation.
    Type: Grant
    Filed: September 13, 1994
    Date of Patent: September 16, 1997
    Assignee: MCW Research Foundation, Inc.
    Inventor: Henry M. Miziorko