Patents by Inventor Henry Sternberg
Henry Sternberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11974207Abstract: Disclosed are systems, methods, and media capable of generating and implementing emergency flows. The emergency flow is highly customizable and can connect with various stakeholders (user, emergency contacts, corporate representatives, emergency service provider personnel, etc.). The systems, methods, and media can be triggered in various ways including user input (e.g. voice command) or by sensors (e.g. by using sound detection capabilities).Type: GrantFiled: October 6, 2022Date of Patent: April 30, 2024Assignee: RapidSOS, Inc.Inventors: Henry Katz, Zvika Ferentz, Jeffrey Sternberg, Nicholas Edward Horelik, Michael John Martin
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Patent number: 11555181Abstract: The present disclosure provides engineered Class 1 Type I CRISPR-Cas (Cascade) systems that comprise multi-protein effector complexes, nucleoprotein complexes comprising Type I CRISPR-Cas subunit proteins and nucleic acid guides, polynucleotides encoding Type I CRISPR-Cas subunit proteins, and guide polynucleotides. Also, disclosed are methods for making and using the engineered Class 1 Type I CRISPR-Cas systems of the present invention.Type: GrantFiled: September 21, 2020Date of Patent: January 17, 2023Assignee: Caribou Biosciences, Inc.Inventors: Peter Sean Cameron, Sanne Eveline Klompe, Samuel Henry Sternberg
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Publication number: 20220372521Abstract: The present disclosure provides methods and systems for resolving cointegrate products from RNA-guided DNA integration. More particularly, the present disclosure provides systems comprising: an engineered Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR associated (Cas) (CRISPR-Cas) system, and/or one or more vectors encoding the engineered CRISPR-Cas system, wherein the CRISPR-Cas system comprises: (a) at least one Cas protein, and (b) a guide RNA (gRNA); an engineered transposon system, and/or one or more vectors encoding the engineered transposon system, wherein the transposon system is configured for replicative transposition; a recombinase, or catalytic domain thereof, and/or one or more vectors encoding a recombinase, or catalytic domain thereof; and at least one donor nucleic acid to be integrated, wherein the donor nucleic acid comprises a recognition site for the recombinase and a cargo nucleic acid flanked by at least one transposon end sequence, and methods of use thereof.Type: ApplicationFiled: August 14, 2020Publication date: November 24, 2022Inventors: Samuel Henry Sternberg, Phuc L.H. Vo
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Publication number: 20210102183Abstract: The present disclosure provides engineered Class 1 Type I CRISPR-Cas (Cascade) systems that comprise multi-protein effector complexes, nucleoprotein complexes comprising Type I CRISPR-Cas subunit proteins and nucleic acid guides, polynucleotides encoding Type I CRISPR-Cas subunit proteins, and guide polynucleotides. Also, disclosed are methods for making and using the engineered Class 1 Type I CRISPR-Cas systems of the present invention.Type: ApplicationFiled: December 11, 2020Publication date: April 8, 2021Applicant: Caribou Biosciences, Inc.Inventors: Peter Sean Cameron, Scott David Gradia, Sanne Eveline Klompe, Samuel Henry Sternberg, Matthew Scott Thompson
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Patent number: 10947534Abstract: In certain embodiments, the present systems and methods use Tn7-like transposons that encode CRISPR-Cas systems for programmable, RNA-guided DNA integration. For example, the CRISPR-Cas machinery directs the Tn7 transposon-associated proteins to integrate DNA downstream of a target site (e.g., a genomic target site) recognized by a guide RNA (gRNA).Type: GrantFiled: March 6, 2020Date of Patent: March 16, 2021Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Samuel Henry Sternberg, Sanne Eveline Klompe
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Publication number: 20210002622Abstract: The present disclosure provides engineered Class 1 Type I CRISPR-Cas (Cascade) systems that comprise multi-protein effector complexes, nucleoprotein complexes comprising Type I CRISPR-Cas subunit proteins and nucleic acid guides, polynucleotides encoding Type I CRISPR-Cas subunit proteins, and guide polynucleotides. Also, disclosed are methods for making and using the engineered Class 1 Type I CRISPR-Cas systems of the present invention.Type: ApplicationFiled: September 21, 2020Publication date: January 7, 2021Inventors: Peter Sean Cameron, Sanne Eveline Klompe, Samuel Henry Sternberg
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Publication number: 20200325474Abstract: In certain embodiments, the present systems and methods use Tn7-like transposons that encode CRISPR-Cas systems for programmable, RNA-guided DNA integration. For example, the CRISPR-Cas machinery directs the Tn7 transposon-associated proteins to integrate DNA downstream of a target site (e.g., a genomic target site) recognized by a guide RNA (gRNA).Type: ApplicationFiled: June 26, 2020Publication date: October 15, 2020Inventors: Samuel Henry Sternberg, Sanne Eveline Klompe
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Patent number: 10781432Abstract: The present disclosure provides engineered Class 1 Type I CRISPR-Cas (Cascade) systems that comprise multi-protein effector complexes, nucleoprotein complexes comprising Type I CRISPR-Cas subunit proteins and nucleic acid guides, polynucleotides encoding Type I CRISPR-Cas subunit proteins, and guide polynucleotides. Also, disclosed are methods for making and using the engineered Class 1 Type I CRISPR-Cas systems of the present invention.Type: GrantFiled: March 19, 2020Date of Patent: September 22, 2020Assignee: Caribou Biosciences, Inc.Inventors: Peter Sean Cameron, Sanne Eveline Klompe, Samuel Henry Sternberg
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Publication number: 20200283769Abstract: In certain embodiments, the present systems and methods use Tn7-like transposons that encode CRISPR-Cas systems for programmable, RNA-guided DNA integration. For example, the CRISPR-Cas machinery directs the Tn7 transposon-associated proteins to integrate DNA downstream of a target site (e.g., a genomic target site) recognized by a guide RNA (gRNA).Type: ApplicationFiled: March 6, 2020Publication date: September 10, 2020Inventors: Samuel Henry Sternberg, Sanne Eveline Klompe
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Publication number: 20200277588Abstract: The present disclosure provides engineered Class 1 Type I CRISPR-Cas (Cascade) systems that comprise multi-protein effector complexes, nucleoprotein complexes comprising Type I CRISPR-Cas subunit proteins and nucleic acid guides, polynucleotides encoding Type I CRISPR-Cas subunit proteins, and guide polynucleotides. Also, disclosed are methods for making and using the engineered Class 1 Type I CRISPR-Cas systems of the present invention.Type: ApplicationFiled: March 19, 2020Publication date: September 3, 2020Applicant: Caribou Biosciences, Inc.Inventors: Peter Sean Cameron, Sanne Eveline Klompe, Samuel Henry Sternberg
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Patent number: 10597648Abstract: The present disclosure provides engineered Class 1 Type I CRISPR-Cas (Cascade) systems that comprise multi-protein effector complexes, nucleoprotein complexes comprising Type I CRISPR-Cas subunit proteins and nucleic acid guides, polynucleotides encoding Type I CRISPR-Cas subunit proteins, and guide polynucleotides. Also, disclosed are methods for making and using the engineered Class 1 Type I CRISPR-Cas systems of the present invention.Type: GrantFiled: October 28, 2019Date of Patent: March 24, 2020Assignee: Caribou Biosciences, Inc.Inventors: Peter Sean Cameron, Sanne Eveline Klompe, Samuel Henry Sternberg
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Publication number: 20200048622Abstract: The present disclosure provides engineered Class 1 Type I CRISPR-Cas (Cascade) systems that comprise multi-protein effector complexes, nucleoprotein complexes comprising Type I CRISPR-Cas subunit proteins and nucleic acid guides, polynucleotides encoding Type I CRISPR-Cas subunit proteins, and guide polynucleotides. Also, disclosed are methods for making and using the engineered Class 1 Type I CRISPR-Cas systems of the present invention.Type: ApplicationFiled: October 28, 2019Publication date: February 13, 2020Inventors: Peter Sean Cameron, Sanne Eveline Klompe, Samuel Henry Sternberg
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Patent number: 10457922Abstract: The present disclosure provides engineered Class 1 Type I CRISPR-Cas (Cascade) systems that comprise multi-protein effector complexes, nucleoprotein complexes comprising Type I CRISPR-Cas subunit proteins and nucleic acid guides, polynucleotides encoding Type I CRISPR-Cas subunit proteins, and guide polynucleotides. Also, disclosed are methods for making and using the engineered Class 1 Type I CRISPR-Cas systems of the present invention.Type: GrantFiled: May 22, 2019Date of Patent: October 29, 2019Assignee: Caribou Biosciences, Inc.Inventors: Peter Sean Cameron, Sanne Eveline Klompe, Samuel Henry Sternberg
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Patent number: 10329547Abstract: The present disclosure provides engineered Class 1 Type I CRISPR-Cas (Cascade) systems that comprise multi-protein effector complexes, nucleoprotein complexes comprising Type I CRISPR-Cas subunit proteins and nucleic acid guides, polynucleotides encoding Type I CRISPR-Cas subunit proteins, and guide polynucleotides. Also, disclosed are methods for making and using the engineered Class 1 Type I CRISPR-Cas systems of the present invention.Type: GrantFiled: January 30, 2019Date of Patent: June 25, 2019Assignee: Caribou Biosciences, Inc.Inventors: Peter Sean Cameron, Sanne Eveline Klompe, Samuel Henry Sternberg
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Patent number: 4311251Abstract: A receptacle for receiving and sequentially dispensing individual shaped bodies from a stack of like bodies. The receptacle has a pivotal cover at the dispensing end thereof and a cap mounted on said cover. The cap has a skirt extending around the pivotal cover. This skirt has a first portion engaging the cover, a second portion adapted to engage the housing of the receptacle when the cover is pivoted toward an open position and a pair of elastically deformable portions intermediate said first and second portions. The elastically deformable portions constitute a spring for biasing the pivoted cover into its closed position. The cover also has a finger portion for pushing the uppermost shaped body and dispensing it from the receptacle when the cover is pivoted against the spring bias.Type: GrantFiled: February 13, 1980Date of Patent: January 19, 1982Inventor: Henry Sternberg