Patents by Inventor Henry Uhlman Bryant

Henry Uhlman Bryant has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Growth hormone secretagogues
    Patent number: 6992097
    Abstract: This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.
    Type: Grant
    Filed: June 3, 2003
    Date of Patent: January 31, 2006
    Assignee: Eli Lilly and Company
    Inventors: Kenneth Lee Hauser, Jeffrey Alan Dodge, Mark Louis Heiman, Scott Alan Jones, Charles Arthur Alt, Henry Uhlman Bryant, Jeffrey Daniel Cohen, James Densmore Copp, Kennan Joseph Fahey, William Harlan Gritton, Louis Nickolaus Jungheim, Joseph Henry Kennedy, Charles Willis Lugar, III, Brian Stephen Muehl, Alan David Palkowitz, Andrew Michael Ratz, Gary Anthony Rhodes, Roger Lewis Robey, David Edward Seyler, Timothy Alan Shepherd, Kenneth Jeff Thrasher, William George Trankle
  • Naphthyl compounds, intermediates, compositions, and methods of use
    Patent number: 6812244
    Abstract: The instant invention provides novel substituted naphthyl compounds, intermediates, compositions, pharmaceutical formulations, and methods of use.
    Type: Grant
    Filed: May 27, 2003
    Date of Patent: November 2, 2004
    Assignee: Eli Lilly and Company
    Inventors: Henry Uhlman Bryant, Thomas Alan Crowell, Charles David Jones, Alan David Palkowitz
  • Growth Hormone secretagogues
    Publication number: 20040122234
    Abstract: This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.
    Type: Application
    Filed: June 3, 2003
    Publication date: June 24, 2004
    Inventors: Kenneth Lee Hauser, Jeffrey Alan Dodge, Mark Louis Heiman, Scott Alan Jones, Charles Arthur Alt, Henry Uhlman Bryant, Jeffrey Daniel Cohen, James Densmore Copp, Kennan Joseph Fahey, William Harlan Gritton, Louis Nickolaus Jungheim, Joseph Henry Kennedy, Charles Willis Lugar, Brian Stephen Muehl, Alan David Palkowitz, Andrew Michael Ratz, Gary Anthony Rhodes, Roger Lewis Robey, David Edward Seyler, Timothy Alan Shepherd, Kenneth Jeff Thrasher, William George Trankle
  • Naphthyl compounds, intermediates, compositions, and methods of use
    Publication number: 20040072820
    Abstract: The instant invention provides novel substituted naphthyl compounds, intermediates, compositions, pharmaceutical formulations, and methods of use.
    Type: Application
    Filed: May 27, 2003
    Publication date: April 15, 2004
    Inventors: Henry Uhlman Bryant, Thomas Alan Crowell, Charles David Jones, Alan David Palkowitz
  • Method for selectively inhibiting ghrelin action
    Publication number: 20030211967
    Abstract: The present invention provides a method selectively inhibiting ghrelin activity to treat a variety of diseases including obesity and related disorders, particularly in individuals who are genetically predisposed. One aspect of the invention comprises administering an agent that effectively neutralizes ghrelin. Another aspect comprises administering a ghrelin receptor (growth hormone secretagogue receptor) antagonist.
    Type: Application
    Filed: October 18, 2002
    Publication date: November 13, 2003
    Inventors: Henry Uhlman Bryant, Mark Louis Heiman
  • Growth hormone secretagogues
    Patent number: 6639076
    Abstract: This invention relates to novel compounds of formula I wherein A, B, D, E, G, J, L, X, V are as defined in the specification, and the compounds are useful in the modulation of endogenous growth hormone levels in a mammal.
    Type: Grant
    Filed: April 17, 2001
    Date of Patent: October 28, 2003
    Assignee: Eli Lilly and Company
    Inventors: Kenneth Lee Hauser, Jeffrey Alan Dodge, Mark Louis Heiman, Scott Alan Jones, Charles Arthur Alt, Henry Uhlman Bryant, James Densmore Copp, William Harlan Gritton, Charles Willis Lugar, III, Brian Stephen Muehl, Alan David Palkowitz, Andrew Michael Ratz, Gary Anthony Rhodes, Roger Lewis Robey, Timothy Alan Shepherd, Kenneth Jeff Thrasher, William George Trankle
  • Naphthalene compounds, intermediates, formulations, and methods
    Patent number: 6599920
    Abstract: This invention relates to the field of pharmaceutical and organic chemistry and provides naphthalene compounds, intermediates, formulations, and methods.
    Type: Grant
    Filed: August 26, 1997
    Date of Patent: July 29, 2003
    Assignee: Eli Lilly and Company
    Inventors: Henry Uhlman Bryant, Thomas Alan Crowell, Charles David Jones
  • Naphthyl compounds, intermediates, compositions, and methods of use
    Patent number: 6593345
    Abstract: The instant invention provides novel substituted naphthyl compounds, intermediates, compositions, pharmaceutical formulations, and methods of use.
    Type: Grant
    Filed: August 27, 1997
    Date of Patent: July 15, 2003
    Assignee: Eli Lilly and Company
    Inventors: Henry Uhlman Bryant, Thomas Alan Crowell, Charles David Jones, Alan David Palkowitz
  • NAPHTHALENE COMPOUNDS, INTERMEDIATES, FORMULATIONS, AND METHODS
    Publication number: 20030100754
    Abstract: This invention relates to the field of pharmaceutical and organic chemistry and provides naphthalene compounds, intermediates, formulations, and methods.
    Type: Application
    Filed: August 26, 1997
    Publication date: May 29, 2003
    Inventors: HENRY UHLMAN BRYANT, THOMAS ALAN CROWELL, CHARLES DAVID JONES
  • Methods for increasing levels of acetylcholine
    Patent number: 6395719
    Abstract: The present invention is directed to increasing levels of acetylcholine by the administration of 2-aryl-3-aroylbenzo[b]thiophenes.
    Type: Grant
    Filed: November 14, 2000
    Date of Patent: May 28, 2002
    Assignee: Eli Lilly and Company
    Inventors: Henry Uhlman Bryant, Michele Annette Glinn, Steven Marc Paul, Xin Wu
  • Treatment of central nervous system disorders with selective estrogen receptor modulators
    Publication number: 20020013342
    Abstract: The present invention provides a method of treating depression, mood swings, or Alzheimer's disease in a patient in need of such treatment by administering a selective estrogen receptor modulating compound of the formula 1
    Type: Application
    Filed: May 4, 2000
    Publication date: January 31, 2002
    Inventors: Kelly Renee Bales, Henry Uhlman Bryant, Steven Marc Paul, Mary Patricia Knadler
  • Methods for increasing levels of acetylcholine
    Publication number: 20010041745
    Abstract: The current invention relates to a method for increasing levels of acetylcholine in mammals comprising administering to a mammal in need thereof, an effective amount of a compound of formula I: 1
    Type: Application
    Filed: March 27, 2000
    Publication date: November 15, 2001
    Inventors: Henry Uhlman Bryant, Steven Marc Paul, Xin Wu, Michele Annette Glinn
  • Benzothiophenes
    Patent number: 6291484
    Abstract: This invention provides novel benzothiophene compounds of the formula I: which are useful for the treatment of the various medical conditions associated with postmenopausal syndrome, as well as estrogen dependent diseases including cancer of the breast, uterus, and cervix. The present invention further relates to pharmaceutical formulations of compounds of formula I.
    Type: Grant
    Filed: January 13, 2000
    Date of Patent: September 18, 2001
    Assignee: Eli Lilly and Company
    Inventors: Henry Uhlman Bryant, Jeffrey Alan Dodge
  • Methods for increasing levels of acetylcholine
    Patent number: 6288108
    Abstract: The current invention relates to a method for increasing levels of acetylcholine comprising administering to a mammal in need thereof, an effective amount of a compound of formula (I), and optionally an AChE inhibitor.
    Type: Grant
    Filed: November 14, 2000
    Date of Patent: September 11, 2001
    Assignee: Eli Lilly and Company
    Inventors: Henry Uhlman Bryant, Michele Annette Glinn, Steven Marc Paul, Xin Wu
  • Method for minimizing the uterotrophic effect of droloxifene
    Patent number: 6110942
    Abstract: The present invention provides a method of minimizing the uterotrophic effect of a compound of formula II ##STR1## or a pharmaceutically acceptable salt or solvate thereof, comprising concurrently or sequentially administering a compound of formula I ##STR2## or pharmaceutically acceptable salt or solvate thereof.
    Type: Grant
    Filed: June 2, 1997
    Date of Patent: August 29, 2000
    Assignee: Eli Lilly and Company
    Inventors: Henry Uhlman Bryant, Jeffrey Alan Dodge
  • Methods for inhibiting detrimental side-effects due to GnRH of GnRH agonist administration
    Patent number: 6096764
    Abstract: A method of inhibiting detrimental side-effects of GnRH or GnRH agonist administration in a mammal which comprises the administration to a mannal in need thereof of an effective amount of a compound of formula I ##STR1## wherein R.sup.1 and R.sup.3 are, independently, --H, --CH.sub.3, --CO(C.sub.1 -C.sub.6 alkyl), or --COAr, where Ar is optionally substituted phenyl;R.sup.3 is selected from the group consisting of pyrrolidine, piperidine, and hexamethyleneimino; ora pharmaceutically acceptable salt or solvate thereof.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: August 1, 2000
    Assignee: Eli Lilly and Company
    Inventors: Henry Uhlman Bryant, George Joseph Cullinan, Jeffrey Alan Dodge
  • Benzothiophenes compounds which have useful pharmaceutical activity
    Patent number: 6090843
    Abstract: This invention provides novel benzothiophene compounds of the formula I: ##STR1## which are useful for the treatment of the various medical conditions associated with postmenopausal syndrome, as well as estrogen dependent diseases including cancer of the breast, uterus, and cervix. The present invention further relates to pharmaceutical formulations of compounds of formula I.
    Type: Grant
    Filed: August 4, 1998
    Date of Patent: July 18, 2000
    Assignee: Eli Lilly and Company
    Inventors: Henry Uhlman Bryant, Jeffrey Alan Dodge
  • Treatment of central nervous system disorders with selective estrogen receptor modulators
    Patent number: 6077852
    Abstract: The present invention provides a method of treating depression, mood swings, or Alzheimer's disease in a patient in need of such treatment by administering a selective estrogen receptor modulating compound of the formula ##STR1## in which R.sup.1 and R.sup.2 are independently hydroxy and alkoxy of one to four carbon atoms; and R.sup.3 and R.sup.4 are independently methyl or ethyl, or R.sup.3 and R.sup.4, taken together with the nitrogen atom to which they are attached, form a pyrrolidino, methyl-pyrrolidino, dimethylpyrrolidino, piperidino, morpholino, or hexamethyleneimino ring.
    Type: Grant
    Filed: April 9, 1998
    Date of Patent: June 20, 2000
    Assignee: Eli Lilly and Company
    Inventors: Kelly Renee Bales, Henry Uhlman Bryant, Steven Marc Paul, Mary Patricia Knadler
  • Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods
    Patent number: 6020513
    Abstract: The instant invention provides dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods for use in the treatment of bone loss or bone resorption.
    Type: Grant
    Filed: July 28, 1998
    Date of Patent: February 1, 2000
    Assignee: Eli Lilly and Company
    Inventors: Henry Uhlman Bryant, Thomas Alan Crowell, Charles David Jones
  • Benzo[b]thiophene compounds, intermediates, formulations, and methods
    Patent number: 6017914
    Abstract: This invention relates to the field of pharmaceutical and organic chemistry and provides benzothiophene compounds, intermediates, formulations, and methods.
    Type: Grant
    Filed: September 3, 1997
    Date of Patent: January 25, 2000
    Assignee: Eli Lilly and Company
    Inventors: Henry Uhlman Bryant, Michael John Martin, Ken Matsumoto