Patents by Inventor Henryk Borowy-Borowski
Henryk Borowy-Borowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140039052Abstract: This invention provides aqueous and non-aqueous clear formulations including at least one lipophilic bioactive molecules and an amphiphilic solubilizing agent. Exemplary aqueous formulations include a water-soluble reducing agent, which diminishes or prevents chemical degradation of the lipophilic bioactive molecule. The invention also provides methods of using the formulations of the invention. For example, the invention provides beverages including the formulations of the invention. The invention further provides methods of making the formulations and beverages.Type: ApplicationFiled: March 14, 2013Publication date: February 6, 2014Inventors: Henryk Borowy-Borowski, Volker Berl
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Patent number: 8524696Abstract: Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula: {X—OOC—[(CH2)n—COO]m}p—Y??(I) wherein: X is a residue of a hydrophobic moiety, Y is a residue of a hydrophilic moiety, p is 1 or 2, m is 0 or 1, and n is an integer greater than or equal to 0 are disclosed. The lipophilic compound is preferably selected from the group consisting of water-insoluble ubiquinones, ubiquinols, vitamins, provitamins, polyene macrolide antibiotics, and mixtures thereof. The hydrophobic moiety is preferably a sterol or a tocopherol and the hydrophilic moiety is preferably a polyalkylene glycol. In some embodiments, the sterol is cholesterol or sitosterol, the tocopherol is ?-(+)-tocopherol, the polyalkylene glycol is a polyethylene glycol or its methyl monoether having an average molecular weight between 400 and 1000, p is equal to 1 or 2, m is equal to 0 or 1 and n is an integer between 2 and 18.Type: GrantFiled: April 28, 2009Date of Patent: September 3, 2013Assignee: National Research Council of CanadaInventors: Henryk Borowy-Borowski, Marianna Sikorska-Walker, P. Roy Walker
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Publication number: 20100063140Abstract: Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula: {X—OOC—[(CH2)n—COO]m}p—Y??(I) wherein: X is a residue of a hydrophobic moiety, Y is a residue of a hydrophilic moiety, p is 1 or 2, m is 0 or 1, and n is an integer greater than or equal to 0 are disclosed. The lipophilic compound is preferably selected from the group consisting of water-insoluble ubiquinones, ubiquinols, vitamins, provitamins, polyene macrolide antibiotics, and mixtures thereof. The hydrophobic moiety is preferably a sterol or a tocopherol and the hydrophilic moiety is preferably a polyalkylene glycol. In some embodiments, the sterol is cholesterol or sitosterol, the tocopherol is ?-(+)-tocopherol, the polyalkylene glycol is a polyethylene glycol or its methyl monoether having an average molecular weight between 400 and 1000, p is equal to 1 or 2, m is equal to 0 or 1 and n is an integer between 2 and 18.Type: ApplicationFiled: April 28, 2009Publication date: March 11, 2010Applicant: National Research Council of CanadaInventors: Henryk Borowy-Borowski, Marianna Sikorska-Walker, P. Roy Walker
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Patent number: 7645816Abstract: Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula: {X—OOC—[(CH2)n—COO]m}p—Y??(I) wherein: X is a residue of a hydrophobic moiety, Y is a residue of a hydrophilic moiety, p is 1 or 2, m is 0 or 1, and n is an integer greater than or equal to 0 are disclosed. The lipophilic compound is preferably selected from the group consisting of water-insoluble ubiquinones, ubiquinols, vitamins, provitamins, polyene macrolide antibiotics, and mixtures thereof. The hydrophobic moiety is preferably a sterol or a tocopherol and the hydrophilic moiety is preferably a polyalkylene glycol. In some embodiments, the sterol is cholesterol or sitosterol, the tocopherol is ?-(+)-tocopherol, the polyalkylene glycol is a polyethylene glycol or its methyl monoether having an average molecular weight between 400 and 1000, p is equal to 1 or 2, m is equal to 0 or 1 and n is an integer between 2 and 18.Type: GrantFiled: August 27, 2003Date of Patent: January 12, 2010Assignee: National Research Council of CanadaInventors: Henryk Borowy-Borowski, Marianna Sikorska-Walker, P. Roy Walker
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Publication number: 20090258038Abstract: Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula: {X—OOC—[(CH2)n—COO]m}p—Y??(I) wherein: X is a residue of a hydrophobic moiety, Y is a residue of a hydrophilic moiety, p is 1 or 2, m is 0 or 1, and n is an integer greater than or equal to 0 are disclosed. The lipophilic compound is preferably selected from the group consisting of water-insoluble ubiquinones, ubiquinols, vitamins, provitamins, polyene macrolide antibiotics, and mixtures thereof. The hydrophobic moiety is preferably a sterol or a tocopherol and the hydrophilic moiety is preferably a polyalkylene glycol. In some embodiments, the sterol is cholesterol or sitosterol, the tocopherol is ?-(+)-tocopherol, the polyalkylene glycol is a polyethylene glycol or its methyl monoether having an average molecular weight between 400 and 1000, p is equal to 1 or 2, m is equal to 0 or 1 and n is an integer between 2 and 18.Type: ApplicationFiled: August 27, 2003Publication date: October 15, 2009Inventors: Henryk Borowy-Borowski, Marianna Sikorska-Walker, P. Walker
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Publication number: 20080254188Abstract: This invention provides aqueous and non-aqueous clear formulations including at least one lipophilic bioactive molecules and an amphiphilic solubilizing agent. Exemplary aqueous formulations include a water-soluble reducing agent, which diminishes or prevents chemical degradation of the lipophilic bioactive molecule. The invention also provides methods of using the formulations of the invention. For example, the invention provides beverages including the formulations of the invention. The invention further provides methods of making the formulations and beverages.Type: ApplicationFiled: February 1, 2008Publication date: October 16, 2008Applicants: National Research Council of Canada, Zymes, LLCInventors: Henryk Borowy-Borowski, Volker Berl
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Publication number: 20080160077Abstract: This invention relates to an improved formulation methodology for bioactive lipophilic molecules, such as Coenzyme Q10 (CoQ10) and its reduced analogs (ubiquinols). Further provided are methods of producing soft gel capsules of this formulation.Type: ApplicationFiled: November 27, 2007Publication date: July 3, 2008Applicant: Zymes, LLCInventor: Henryk Borowy-Borowski
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Publication number: 20080070981Abstract: Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula: {X—OOC—[(CH2)n—COO]m}p—Y??(I) wherein: X is a residue of a hydrophobic moiety, Y is a residue of a hydrophilic moiety, p is 1 or 2, m is 0 or 1, and n is an integer greater than or equal to 0 are disclosed. The lipophilic compound is preferably selected from the group consisting of water-insoluble ubiquinones, ubiquinols, vitamins, provitamins, polyene macrolide antibiotics, and mixtures thereof. The hydrophobic moiety is preferably a sterol or a tocopherol and the hydrophilic moiety is preferably a polyalkylene glycol. In some embodiments, the sterol is cholesterol or sitosterol, the tocopherol is ?-(+)-tocopherol, the polyalkylene glycol is a polyethylene glycol or its methyl monoether having an average molecular weight between 400 and 1000, p is equal to 1 or 2, m is equal to 0 or 1 and n is an integer between 2 and 18.Type: ApplicationFiled: July 30, 2007Publication date: March 20, 2008Inventors: Henryk Borowy-Borowski, Marianna Sikorska-Walker, P. Walker
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Publication number: 20040156871Abstract: Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula:Type: ApplicationFiled: August 27, 2003Publication date: August 12, 2004Inventors: Henryk Borowy-Borowski, Marianna Sikorska-Walker, P. Roy Walker
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Patent number: 6632443Abstract: Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula: {X—OOC—[(CH2)n—COO]m}p—Y (I) wherein: X is a residue of a hydrophobic moiety, Y is a residue of a hydrophilic moiety, p is 1 or 2, m is 0 or 1, and n is an integer greater than or equal to 0 are disclosed. The lipophilic compound is preferably selected from the group consisting of water-insoluble ubiquinones, ubiquinols, vitamins, provitamins, polyene macrolide antibiotics, and mixtures thereof. The hydrophobic moiety is preferably a sterol or a tocopherol and the hydrophilic moiety is preferably a polyalkylene glycol. In some embodiments, the sterol is cholesterol or sitosterol, the tocopherol is &agr;-(+)-tocopherol, the polyalkylene glycol is a polyethylene glycol or its methyl monoether having an average molecular weight between 400 and 1000, p is equal to 1 or 2, m is equal to 0 or 1 and n is an integer between 2 and 18.Type: GrantFiled: February 2, 2001Date of Patent: October 14, 2003Assignee: National Research Council of CanadaInventors: Henryk Borowy-Borowski, Marianna Sikorska-Walker, P. Roy Walker
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Publication number: 20010025058Abstract: Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula:Type: ApplicationFiled: February 2, 2001Publication date: September 27, 2001Inventors: Henryk Borowy-Borowski, Marianna Sikorska-Walker, P. Roy Walker
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Patent number: 6191172Abstract: Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula: wherein: X is a residue of a hydrophobic moiety, Y is a residue of a hydrophilic moiety, p is 1 or 2, m is 0 or 1, and n is an integer greater than or equal to 0 are disclosed. The lipophilic compound is preferably selected from the group consisting of water-insoluble ubiquinones, ubiquinols, vitamins, provitamins, polyene macrolide antibiotics, and mixtures thereof. The hydrophobic moiety is preferably a sterol or a tocopherol and the hydrophilic moiety is preferably a polyalkylene glycol. In preferred embodiments, the sterol is cholesterol or sitosterol, the tocopherol is a-(+)-tocopherol, the polyalkylene glycol is a polyethylene glycol or its methyl monoether having an average molecular weight between 600 and 1000, p is equal to 1 or 2, m is equal to 0 or 1 and n is an integer between 2 and 18.Type: GrantFiled: February 23, 2000Date of Patent: February 20, 2001Assignee: National Research Council of CanadaInventors: Henryk Borowy-Borowski, Marianna Sikorska-Walker, P. Roy Walker
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Patent number: 6045826Abstract: Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula:{X--OOC--[(CH.sub.2).sub.n --COO].sub.m }.sub.p --Y (I)wherein:X is a residue of a hydrophobic moiety,Y is a residue of a hydrophilic moiety,p is 1 or 2,m is 0 or 1, andn is an integer greater than or equal to 0are disclosed. The lipophilic compound is preferably selected from the group consisting of water-insoluble ubiquinones, ubiquinols, vitamins, provitamins, polyene macrolide antibiotics, and mixtures thereof. The hydrophobic moiety is preferably a sterol or a tocopherol and the hydrophilic moiety is preferably a polyalkylene glycol. In preferred embodiments, the sterol is cholesterol or sitosterol, the tocopherol is a-(+)-tocopherol, the polyalkylene glycol is a polyethylene glycol or its methyl monoether having an average molecular weight between 600 and 1000, p is equal to 1 or 2, m is equal to 0 or 1 and n is an integer between 2 and 18.Type: GrantFiled: April 2, 1999Date of Patent: April 4, 2000Assignee: National Research Council of CanadaInventors: Henryk Borowy-Borowski, Marianna Sikorska-Walker, P. Roy Walker