Abstract: Disclosed herein are compositions and methods of treating a subject with cancer. The compositions and methods utilize immunoresponsive cells to effect killing of tumor cells.

Abstract: The current invention provides methods to identify ?9?2T-cell receptors (?9?2TCR) that mediate anti-tumour responses. Surprisingly, it was now found that the CDR3 regions of the ?9-T-cell receptor chain and the ?2-T-Cell receptor chain (?2TCR chain) are of importance. Based on these findings, combinatorial-??TCR-chain-exchange (CTE) is proposed as an efficient method for identifying ?9?2TCRs that mediate anti-tumour responses. Using the method of the invention, specific sequences of the respective ?9TCR and ?2TCR chains were identified that mediate anti-tumour responses. Hence, the invention further provides for specific ?9?2TCRs, or fragments thereof, that may be used e.g. in diagnostics or treatment of cancer. The invention further provides for nucleic acid sequences, genetic constructs and retroviral vectors that can be used to express the ?9?2TCRs according to the invention.

Abstract: Disclosed herein are compositions and methods of treating a subject with cancer. The compositions and methods utilize immunoresponsive cells to effect killing of tumor cells.

Abstract: A method and a device for determining wheel slip information of an electrically driven wheel of a motor vehicle, according to which during travel, the speed (nE-motor) of an electric motor driving the wheel is detected and the detected speed (nE-motor) of the electric motor is used to determine the wheel slip information.

Abstract: Methods and systems are provided for a coolant circuit. In one example, the coolant circuit comprises high and low-temperature radiators, where only one pump is configured to conduct coolant through the entire coolant circuit.

Abstract: A method for operating an assistance system of a motor vehicle, with a first control unit and with a second control unit, wherein a first rotational speed sensor is connected to the first control unit for recording a rotational speed of a first wheel, wherein a second rotational speed sensor is connected to the second control unit for recording a rotational speed of a second wheel, and wherein the first control unit is coupled to the second control unit using signal technology.

Abstract: The current disclosure provides for immune cells expressing immune receptors comprising i) a polypeptide having an antigen binding domain, a TCR ?-chain constant domain, and a TCR ?-chain transmembrane domain; and/or ii) a polypeptide having an antigen binding domain, a TCR ?-chain constant domain, and a TCR ?-chain transmembrane domain. The current disclosure also provides for immune cell expressing immune receptors comprising an antigen binding domain, and a transmembrane domain, wherein the antigen binding domain specifically binds a binding moiety that in turn specifically binds a target, for example, a cancer cell. The immune cells, optionally in combination with the binding moiety, can be used in medical treatment, preferably the treatment of a cancer.

Abstract: A method for controlling at least one wireless network access point in a building may include detecting whether a wireless communication device is connected to at least one wireless network access point and/or whether a person is present using a group of presence detectors. An illumination system may include at least one wireless network point and/or the group of presence detectors. An activated network access point may remain activated when the wireless network access point is connected to a wireless communication device and/or when a person is present. A network access point may be automatically deactivated when the wireless network access point is not connected to a wireless communication device and/or when a person is not present. A deactivated network access point may be automatically reactivated when the wireless network access point is connected to a wireless communication device and/or when a person is present. Combinations thereof are also possible.

Abstract: A system for providing a wireless network may include a plurality of wireless access points for a delimited spatial area in a building or physical structure. At least one spatial zone controller may be connected to at least some of the wireless access points and is configured to receive, via the wireless access points connected to the controller, device information regarding a terminal logging into the network and/or regarding an external wireless access point, and to determine the spatial position of the terminal and/or of the external wireless access point or the physical structure. In addition, a central security controller may be connected to the spatial zone controller to provide an access control list. The spatial zone controller may be configured to compare the received device information and the determined spatial position with the access control list.

Abstract: Methods and systems are provided for a piston. In one example, system may comprise a piston comprising a chamber in which a piston bowl may actuated independent of an oscillation of the piston. The chamber may receive a hydraulic fluid in order to adjust a position of the piston bowl within the chamber, thereby adjusting a compression ratio of a combustion chamber in which the piston may oscillate.

Abstract: The present invention relates to a method for identifying ?T-cell (or ?T-cell) receptors chains or parts thereof that mediate an anti-tumor or anti-infection response by identifying amino acid sequences comprising ?T-cells (or ?T-cell) receptors chains or parts thereof that are shared between different donors.

Abstract: A method for activating a parking brake of a motor vehicle, wherein the parking brake is activated automatically if the motor vehicle is at a standstill or its ignition is switched off. The motor vehicle and/or the environment is detected subsequent to the automatic activation of the parking brake, and that said current situation is compared to stored situations of the motor vehicle and/or the environment, for which a rolling capability of the motor vehicle at a standstill and/or with its ignition switched off has been designated.

Abstract: The present invention relates to a method for identifying ?T-cell (or ?T-cell) receptors chains or parts thereof that mediate an anti-tumor or anti-infection response by identifying amino acid sequences comprising ?T-cells (or ?T-cell) receptors chains or parts thereof that are shared between different donors.

Abstract: Methods and systems are provided for estimating a drive train temperature for a journey. In one example, a method comprises requesting a vehicle operator to input one or more travel parameters for the journey, predicting travel parameters the vehicle operator omitted to input, and displaying an estimated fuel economy for the journey, where the estimated fuel economy is based on the estimated drive train temperature, which is based on the travel parameters.

Abstract: A method for setting up a lighting system comprising at least two luminaires, which are part of a network and each having a unique network address, wherein each luminaire has at least one sensor and one actuator, characterized by the steps of measuring the relative distance between respectively two luminaires by reading at least one sensor of the luminaire while simultaneously activating at least one actuator of the other luminaire, producing at least one data record, wherein each data record contains the network address of both luminaires and the relative distance of the luminaires from one another, and merging the data records to form a geo-localized network list and comparing the network list to a floorplan underlying the lighting system to determine the physical location of each luminaire.

Abstract: The current application provides for exogenous immune receptors that do not require any additional selection marker genes and/or any additional silicide genes. The disclosure allows for the production of engineered T cells that can be enriched for in an untouched manner, i.e., the engineered T cells do not require any interaction with any outside agent and can be selected for by eliminating T cells that express the endogenous alpha beta T cell receptor. Engineered T cells with an exogenous immune receptor are provided that can be differentiated from endogenous T cell receptor and now can be eliminated, i.e., depleted, with a selective antibody that specifically targets the exogenous immune receptor.

Abstract: A method for optimizing the area coverage of a wireless network may include a lamp to perform this method. The lamp may have an input for connecting a network, a power supply unit for supplying all components of the lamp with an electric power taken from the input, a control unit for controlling the components of the lamp, at least one light source from the power supply unit and controlled by the control unit, and a network access point for providing at least one wireless network. The lamp may include at least one antenna associated with the network access point. The light source and antenna may be arranged and designed such that the radiation characteristics of the light are congruent with the radiation characteristics of the antenna of the wireless network.

Abstract: Methods and systems are provided for a control device for adjusting coolant flow. In one example, the control device may be shaped to receive charge air, engine coolant, and charge-air cooler coolant to adjust a flow of charge-air cooler coolant to a radiator.

Abstract: Described herein are compositions and methods of treatment for identifying and clearing cell types expressing particular cell surface markers. In one embodiment, the composition comprises a polypeptide construct that selectively binds a J-configuration of CD277 on a target cell, wherein said polypeptide construct is expressed in an engineered cell.

Abstract: A method for controlling at least one wireless network access point in a building may include detecting whether a wireless communication device is connected to at least one wireless network access point and/or whether a person is present using a group of presence detectors. An illumination system may include at least one wireless network point and/or the group of presence detectors. An activated network access point may remain activated when the wireless network access point is connected to a wireless communication device and/or when a person is present. A network access point may be automatically deactivated when the wireless network access point is not connected to a wireless communication device and/or when a person is not present. A deactivated network access point may be automatically reactivated when the wireless network access point is connected to a wireless communication device and/or when a person is present. Combinations thereof are also possible.