Patents by Inventor Herbert Nowak
Herbert Nowak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4463690Abstract: A lining for a furnace chamber which is at least approximately round in cross-section is divided into at least two layers in a radial direction and into at least two portions in an axial direction. A gas seal is disposed between the lining portions, the gas seal being in the form of a foil as of metal and being divided in a radial direction into at least two portions releasably connected together in such a manner as to permit the inner portion to be removed in an axial direction. The gas seal can therefore be composed of individual seal portions, in a radial direction, and can be fitted separately.Type: GrantFiled: June 18, 1982Date of Patent: August 7, 1984Assignees: Rheinische Braunkohlenwerke AG, Karrenh GmbHInventors: Wolfgang Hermann, Bernhard Ruter, Rainer Gorris, Herbert Nowak
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Patent number: 4072754Abstract: Hydratropic acid derivatives of the formula ##STR1## wherein R.sub.1 is H, alkyl of 1-4 carbon atoms, 2-acetamidoethyl, 1-methyl-4-piperidyl, or 2,3-dihydroxypropyl, and R.sub.2 is Hal, phenyl, 4-Hal-phenyl, 4-Hal-phenoxy, 4-Hal-phenoxymethyl, 1,2,3,4-tetrahydro-1-naphthyl, 1-pyrryl, piperidino, isoindolino, 1,2,3,4-tetrahydroquinolino, 1,2,3,4-tetrahydro-4-quinolyl or 1-methyl-1,2,3,4-tetrahydro-4-quinolyl, Hal being F, Cl, or Br, and the physiologically acceptable salts thereof, which possess cholesterol and triglyceride serum-level-lowering activity, can be prepared by reacting a phenol of the formula ##STR2## with a compound of the formula X--C(CH.sub.3)(C.sub. 6 H.sub.5)--COOR.sub.1 wherein X represents Cl, Br, I, OH, or esterified OH.Type: GrantFiled: November 25, 1974Date of Patent: February 7, 1978Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Erich Schacht, Werner Mehrhof, Zdenek Simane, Herbert Nowak, Detlev Kayser
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Patent number: 4070461Abstract: Biphenylyl ethers of the formula ##STR1## and their physiologically acceptable acid addition salts exhibit pharmaceutically useful serum cholesterol and triglyceride lowering, fibrinolytic, thrombocyte aggregation inhibition, .beta.-receptor blocking and neuroleptic effects.Type: GrantFiled: February 5, 1976Date of Patent: January 24, 1978Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Erich Schacht, Rochus Jonas, Werner Mehrhof, Herbert Nowak, Zdenek Simane, Reinhard Lissner
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Patent number: 4060609Abstract: Biphenylyl ethers of the formula R--O--CH.sub.2 --CR.sub.1 (OH)--CH.sub.2 Z wherein R.sub.1 is H or CH.sub.3 ; Z is dialkylamino of 2-8 carbon atoms, morpholino, pyrrolidino, piperidino, homopiperidino, hydroxypyrrolidino, hydroxypiperidino or hydroxyhomopiperidino; R is either biphenylyl substituted by at least one of F, Cl, Br, I, CF.sub.3, NO.sub.2 and piperidino or, when R.sub.1 is CH.sub.3 or when Z is homopiperidino, hydroxypyrrolidino, hydroxypiperidino or hydroxyhomopiperidino, unsubstituted biphenyl, and the physiologically acceptable acid addition salts thereof, possess cholesterol blood-level-lowering activity and can be produced by reacting a compound of the formula R--O--CH.sub.2 --Y wherein Y is ##STR1## or --CR.sub.1 (OH)--CH.sub.2 X, X being Cl, Br, I or a free or functionally modified OH-group, with an amine of the formula H-Z.Type: GrantFiled: October 29, 1974Date of Patent: November 29, 1977Assignee: Merch Patent Gesellschaft mit beschrankter HaftungInventors: Erich Schacht, Werner Mehrhof, Rochus Jonas, Herbert Nowak, Zdenek Simane
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Patent number: 4053626Abstract: Phenoxyacetic acids of the formula ##STR1## wherein R.sub.1 is H or alkyl of 1-4 carbon atoms; R.sub.2 is H, or when R.sub.4 is Q, also alkyl of 1-4 carbon atoms; R.sub.3 is methyl, phenyl or chlorophenyl; and R.sub.4 is piperidino, isoindolino, 1,2,3,4-tetrahydroquinolino, 1-R.sub.5 -1,2,3,4-tetrahydro-4-quinolyl, 4-piperidinophenyl, 4-piperidinophenoxy, 1-pyrryl, or Q, wherein R.sub.5 is H or alkyl of 1-4 carbon atoms; and Q is 4-oxo-1,2,3,4-tetrahydroquinolino, 4-hydroxy-1,2,3,4-tetrahydroquinolino, 4-chromanyl, 4-thiochromanyl or 1-phenyl-1,2,3,4-tetrahydro-4-quinolyl; and the salts thereof, possess cholesterol level-lowering activity.Type: GrantFiled: September 17, 1976Date of Patent: October 11, 1977Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Erich Schacht, Werner Mehrhof, Herbert Nowak, Zdenek Simane, Detlev Kayser
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Patent number: 4051170Abstract: Diphenoxyacetic acid derivatives of the general formula ##STR1## wherein R.sub.1 is H or alkyl of 1-4 carbon atoms, R.sub.2 is H or Cl, R.sub.2 is H or Cl, R.sub.3 is piperidino, 4-piperidinophenyl, 1,2,3,4-tetrahydroquinolino, 1-R.sub.4 -1,2,3,4-tetrahydro-4-quinolyl, 4-oxo-1,2,3,4-tetrahydroquinolino, 4-chromanyl, 4-thiochromanyl or 4-chlorophenoxy, and R.sub.4 is H or alkyl of 1-4 carbon atoms, and the physiologically acceptable salts thereof, possess cholesterol level lowering activity and can be prepared by reacting a phenol of the formula ##STR2## with a compound of the formula ##STR3## wherein X is OH, esterified OH, Cl, Br or I, one R is R.sub.2 and the other is R.sub.3 ; or by cyclizing a compound of the formula ##STR4## wherein X.sub.1 is Cl, Br, I, NH.sub.2 OH or an esterified or etherified OH-group and n is 0 or 1; or by treating a compound of the formula ##STR5## wherein Z is a functionally modified carboxyl group different from COOR.sub.1, with a solvolyzing agent, R.sub.1, R.sub.2 and R.sub.Type: GrantFiled: December 11, 1974Date of Patent: September 27, 1977Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Erich Schacht, Werner Mehrhof, Zdenek Simane, Detlev Kayser, Herbert Nowak
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Patent number: 4051173Abstract: Phenoxylakanols of the formula ##STR1## wherein R.sup.1 is H or CH.sub.3 ; R.sup.2 is CH.sub.3 or C.sub.6 H.sub.5 ; R.sup.3 is 4-Hal-phenoxymethyl, 1,2,3,4-tetrahydro-1-naphthyl, 1-pyrryl, piperidino, isoindoline, 1,2,3,4-tetrahydroquinoline, 1,2,3,4-tetrahydro-1-R.sup.5 -4-quinolyl, 4-chromanyl, 4-thiochromanyl, or, when at least one of R.sup.1 and R.sup.2 is other than CH.sub.3, also Hal, phenyl, 4-Hal-phenyl or 4-Hal-phenoxy, wherein R.sup.4 is H or alkanoyl of 2-4 carbon atoms, R.sup.5 is H or CH.sub.3 and Hal if F, Cl or Br; and physiologically acceptable acid addition salts thereof possess pharmacological activity, particularly cholesterol, triglyceride and uric acid blood-level lowering activity and are also useful as intermediates for the production of the corresponding phenoxyacetic acids.Type: GrantFiled: June 9, 1976Date of Patent: September 27, 1977Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Erich Schacht, Werner Mehrhof, Zdenek Simane, Herbert Nowak
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Patent number: 4039683Abstract: Phenoxypropionic acid derivatives of the formula ##STR1## wherein Q is H or a halogen atom, R is H or CH.sub.3, Z is --OH, --O--alkyl of 1-4 carbon atoms, 1-methyl-4-piperidyloxy, or --NHCH.sub.2 CH.sub.2 OH, and the physiologically acceptable salts thereof; possess cholesterol and triglyceride blood-level lowering activity and can be prepared, e.g., by reaction of a phenol of the formula ##STR2## with a compound of the formula X--CR(CH.sub.3)--CO--Z wherein X is Cl, Br, I, or a free or esterified OH-group, and Q, R and Z have the values given above.Type: GrantFiled: December 24, 1975Date of Patent: August 2, 1977Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Erich Schacht, Gunter Lauterbach, Werner Mehrhof, Herbert Nowak, Zdenek Simane
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Patent number: 4021555Abstract: Administration of mepiprazole during L-dopa therapy for parkinsonism reduces undesired side effects of L-dopa and enhances the desired effects of L-dopa.Type: GrantFiled: December 16, 1975Date of Patent: May 3, 1977Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Christoph Seyfried, Herbert Nowak
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Patent number: 3992386Abstract: Phenoxyacetic acids of the formula ##SPC1##Wherein R.sub.1 is H or alkyl of 1-4 carbon atoms; R.sub.2 is H, or when R.sub.4 is Q, also alkyl of 1-4 carbon atoms; R.sub.3 is methyl, phenyl or chlorophenyl; and R.sub.4 is piperidino, isoindolino, 1,2,3,4-tetrahydroquinolino, 1-R.sub.5 -1,2,3,4-tetrahydro-4-quinolyl, 4-piperidinophenyl, 4-piperidinophenoxy, 1-pyrryl, or Q, wherein R.sub.5 is H or alkyl of 1-4 carbon atoms; and Q is 4-oxo-1,2,3,4-tetrahydroquinolino, 4-hydroxy-1,2,3,4-tetrahydroquinolino, 4-chromanyl, 4-thiochromanyl or 1-phenyl-1,2,3,4-tetrahydro-4-quinolyl; and the salts thereof, possess cholesterol level-lowering activity.Type: GrantFiled: March 8, 1974Date of Patent: November 16, 1976Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Erich Schacht, Werner Mehrhof, Herbert Nowak, Zdenek Simane, Detlev Kayser
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Patent number: 3968143Abstract: Phenoxypropionic acid derivatives of the formula ##SPC1##Wherein Q is H or a halogen atom, R is H or CH.sub.3, Z is --OH, --O-alkyl of 1-4 carbon atoms, 1-methyl-4-piperidyloxy, or --NHCH.sub.2 CH.sub.2 OH, and the physiologically acceptable salts thereof; possess cholesterol and triglyceride blood-level lowering activity and can be prepared, e.g., by reaction of a phenol of the formula ##SPC2##With a compound of the formula X--CR(CH.sub.3)--CO--Z wherein X is Cl, Br, I, or a free or esterified OH-group, and Q, R and Z have the values given above.Type: GrantFiled: August 14, 1974Date of Patent: July 6, 1976Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Erich Schacht, Gunter Lauterbach, Werner Mehrhof, Herbert Nowak, Zdenek Simane
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Patent number: 3956334Abstract: Piperidines of the formula ##SPC1##Wherein R is --CH.sub.2 OH, CO--NR,R.sub.2 in which R.sub.1 and R.sub.2 each are H or alkyl of 1-4 carbon atoms, --NHCH.sub.2 CH.sub.2 OH, --N(CH.sub.2 CH.sub.2 OH).sub.2, --NHCH.sub.2 CH.sub.2 SO.sub.3 H, --NHNH.sub.2 or --NHCH.sub.2 COOH, or --COOR.sub.3 in which R.sub.3 is 3-pyridylmethyl, 2-acetamidoethyl, 1-methyl-4-piperidyl or 2,3-dihydroxypropyl and the physiologically acceptable salts thereof, have cholesterol-level-lowering and triglyceride-level-lowering activity and can be prepared from 2-methyl-2-[4-(4-piperidinophenyl)-phenoxy]-propionic acid or a functional derivative thereof by reduction or by reaction with a compound of the formula HZ.Type: GrantFiled: June 26, 1974Date of Patent: May 11, 1976Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Erich Schacht, Werner Mehrhof, Herbert Nowak, Zdenek Simane