Patents by Inventor Herbert Stepp
Herbert Stepp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11490816Abstract: The present invention is directed to an apparatus (10) for reliable quantitative measurement of a fluorescent blood analyte in tissue (12) comprising: at least one light source (14), the light source (14) emitting excitation light at least at a first wavelength range between 350 nm and 450 nm to the tissue (12); a detection unit (16), the detection unit (16) measuring: a) a portion of the fluorescent light emitted by the fluorescent blood analyte excited at the first wavelength range; and b) a portion of the auto fluorescence emitted by the tissue (12); and/or c1) a portion of the remitted excitation light at the first wavelength range, and c2) a portion of the remitted light at a second wavelength range; and a control unit (18), the control unit (18) operating the light source (14) and detection unit (16). The present invention is further directed to a method for quantitative measurement of a fluorescent blood analyte in tissue (12).Type: GrantFiled: February 17, 2016Date of Patent: November 8, 2022Assignee: FerroSens GmbHInventors: Herbert Stepp, Georg Hennig, Christian Homann
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Publication number: 20190110718Abstract: An apparatus and method for noninvasive measurement of a fluorescent analyte concentration in the blood of a patient by exciting the blood and the analyte at two wavelength ranges and measuring the emission spectrum of the fluorescent analyte when (i) the difference of emission intensities at the excitation wavelength ranges of the fluorescent analyte is greater than that of background fluorophores, and (ii) when blood absorbance at the two excitation wavelength ranges is similar. An apparatus and method for measurement of a fluorescent analyte concentration in the blood of a patient is provided.Type: ApplicationFiled: May 10, 2018Publication date: April 18, 2019Inventors: Gary M. Brittenham, Herbert Stepp, Georg Hennig
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Patent number: 9999382Abstract: An apparatus and method for noninvasive measurement of a fluorescent analyte concentration in the blood of a patient by exciting the blood and the analyte at two wavelength ranges and measuring the emission spectrum of the fluorescent analyte when (i) the difference of emission intensities at the excitation wavelength ranges of the fluorescent analyte is greater than that of background fluorophores, and (ii) when blood absorbance at the two excitation wavelength ranges is similar. An apparatus and method for measurement of a fluorescent analyte concentration in the blood of a patient is provided.Type: GrantFiled: March 14, 2014Date of Patent: June 19, 2018Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Gary M Brittenham, Herbert Stepp, Georg Hennig
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Publication number: 20180042482Abstract: The present invention is directed to an apparatus (10) for reliable quantitative measurement of a fluorescent blood analyte in tissue (12) comprising: at least one light source (14), the light source (14) emitting excitation light at least at a first wavelength range between 350 nm and 450 nm to the tissue (12); a detection unit (16), the detection unit (16) measuring: a) a portion of the fluorescent light emitted by the fluorescent blood analyte excited at the first wavelength range; and b) a portion of the auto fluorescence emitted by the tissue (12); and/or c1) a portion of the remitted excitation light at the first wavelength range, and c2) a portion of the remitted light at a second wavelength range; and a control unit (18), the control unit (18) operating the light source (14) and detection unit (16). The present invention is further directed to a method for quantitative measurement of a fluorescent blood analyte in tissue (12).Type: ApplicationFiled: February 17, 2016Publication date: February 15, 2018Inventors: Herbert STEPP, Georg HENNIG, Christian HOMANN
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Patent number: 9585612Abstract: A fluorescence diagnosis system has a viewing system at least one light source and a camera system. The at least one light source can be operated in three modes, a first generating white light, a second with a first fluorescence excitation light of a first excitation wavelength and a third in which a second fluorescence excitation light of a second excitation wavelength is generated producing a fluorescence image in the NIR range. The camera system is sensitive at least in the visible and the NIR range. The system further comprises an image processing system for converting the fluorescence image in the NIR range into a visible image.Type: GrantFiled: February 24, 2006Date of Patent: March 7, 2017Assignee: Karl Storz GmbH & Co. KGInventors: Klaus M. Irion, André Ehrhardt, Reinhold Baumgartner, Herbert Stepp, Thomas Pongratz
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Publication number: 20140235973Abstract: An apparatus and method for noninvasive measurement of a fluorescent analyte concentration in the blood of a patient by exciting the blood and the analyte at two wavelength ranges and measuring the emission spectrum of the fluorescent analyte when (i) the difference of emission intensities at the excitation wavelength ranges of the fluorescent analyte is greater than that of background fluorophores, and (ii) when blood absorbance at the two excitation wavelength ranges is similar. An apparatus and method for measurement of a fluorescent analyte concentration in the blood of a patient is provided.Type: ApplicationFiled: March 14, 2014Publication date: August 21, 2014Applicant: The Trustees of Columbia University in the City of New YorkInventors: Gary M Brittenham, Herbert Stepp, Georg Hennig
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Patent number: 8520919Abstract: In a method for controlling a multi-color output of an image of a medical object for assisting medical personnel, the medical object is illuminated with light with an illumination spectrum. By means of an image sensor, image data are acquired for a group of one or more color channels. Image information concerning an additional color channel, which is not among the group of one or more color channels, is generated depending on the acquired image data. An image output device for multi-color output of the image is controlled depending on the acquired image data and the acquired image information.Type: GrantFiled: June 17, 2010Date of Patent: August 27, 2013Assignee: Karl Storz GmbH & Co. KGInventors: Herbert Stepp, Hilmar Schachenmayr
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Publication number: 20100322492Abstract: In a method for controlling a multi-color output of an image of a medical object for assisting medical personnel, the medical object is illuminated with light with an illumination spectrum. By means of an image sensor, image data are acquired for a group of one or more color channels. Image information concerning an additional color channel, which is not among the group of one or more color channels, is generated depending on the acquired image data. An image output device for multi-color output of the image is controlled depending on the acquired image data and the acquired image information.Type: ApplicationFiled: June 17, 2010Publication date: December 23, 2010Inventors: Herbert Stepp, Hilmar Schachenmayr
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Patent number: 7794388Abstract: A method for generating at least one section of a virtual 3D model of a body interior, in particular a hollow organ, uses data that are provided by at least one endoscope introduced into the body interior. The data comprise at least one position and orientation of the endoscope, the at least one position and orientation being assigned at least one distance between the endoscope and the at least one point on a surface of the body interior, and at least one endoscopic image of the surface of the body interior in the region of the at least one point on the surface of the body interior. From the said data relating to a number of different positions and orientations of the endoscope is/are generated the section or sections of the 3D model in superposition with the associated endoscopic image. An appropriate apparatus is also described.Type: GrantFiled: August 11, 2006Date of Patent: September 14, 2010Assignees: Karl Storz GmbH & Co. KG, Ludwig-Maximilian-UniversitaetInventors: Wolfgang Draxinger, Margarita Noll, Herbert Stepp, Klaus M. Irion
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Publication number: 20070060792Abstract: A method for generating at least one section of a virtual 3D model of a body interior, in particular a hollow organ, uses data that are provided by at least one endoscope introduced into the body interior. The data comprise at least one position and orientation of the endoscope, the at least one position and orientation being as signed at least one distance between the endoscope and the at least one point on a surface of the body interior, and at least one endoscopic image of the surface of the body interior in the region of the at least one point on the surface of the body interior. From the said data relating to a number of different positions and orientations of the endoscope is/are generated the section or sections of the 3D model in superposition with the associated endoscopic image. An appropriate apparatus is also described.Type: ApplicationFiled: August 11, 2006Publication date: March 15, 2007Inventors: Wolfgang Draxinger, Margarita Noll, Herbert Stepp, Klaus Irion
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Publication number: 20070053204Abstract: The invention relates to a confocal microendoscope, in which the diameter of optical fibres at the proximal end (8) of an optical fibre bundle (9) is greater than at the distal end (15). This permits the efficiency of coupling the light of a light source to be increased, without reducing the resolution of the microendoscope. In addition, the proximal ends (8) of the optical fibres (10) are arranged in a grid, for example, by means of a fibre receiving unit (11) that holds the individual optical fibres. A microlens unit (13) can also be provided, said unit allocating a microlens (14) to each optical fibre end.Type: ApplicationFiled: September 10, 2004Publication date: March 8, 2007Applicants: FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWAND, KARL STORZ GMBH & CO. KGInventors: Ingo Krohne, Andre Ehrhardt, Klaus Irion, Herbert Stepp
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Publication number: 20060241499Abstract: A fluorescence diagnosis system has a viewing system at least one light source and a camera system. The at least one light source can be operated in three modes, a first generating white light, a second with a first fluorescence excitation light of a first excitation wavelength and a third in which a second fluorescence excitation light of a second excitation wavelength is generated producing a fluorescence image in the NIR range. The camera system is sensitive at least in the visible and the NIR range. The system further comprises an image processing system for converting the fluorescence image in the NIR range into a visible image.Type: ApplicationFiled: February 24, 2006Publication date: October 26, 2006Inventors: Klaus Irion, Andre Ehrhardt, Reinhold Baumgartner, Herbert Stepp, Thomas Pongratz
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Patent number: 6640131Abstract: An endoscopic or microscopic apparatus for diagnosis by means of a light-induced reaction in biologic tissue “in vivo” which is created by a photo-amboceptor or by autofluorescence is provided. The inventive apparatus is characterized by the feature that at least one reference wavelength &lgr;r is provided which is longer by up to 2&Dgr;&lgr; at maximum or smaller than the wavelength &lgr;s at the point of intersection.Type: GrantFiled: March 14, 2001Date of Patent: October 28, 2003Assignee: Karl Storz GmbH & Co. KGInventors: Klaus M. Irion, Herbert Stepp, Andre Erhardt, Hans Tafelmaier
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Patent number: 6510338Abstract: A method of and a device for the endoscopic fluorescence diagnosis of tissue, wherein the tissue is exposed to stimulating light via an endoscope for stimulation of fluorescence, which stimulating light is suitable, on account of its spectral distribution, to stimulate at least two different fluorescence modes in the tissue without filter switching in the stimulation beam path, and wherein the fluorescence light of the different fluorescence modes can be selectively observed.Type: GrantFiled: August 7, 2000Date of Patent: January 21, 2003Assignee: Karl Storz GmbH & Co. KGInventors: Klaus M. Irion, André Erhardt, Herbert Stepp, Josef Peter Pichler
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Patent number: 6212425Abstract: A device for “in vivo” diagnosis by means of a photosensibilisator light-induced reaction or a reaction caused by intrinsic fluorescence in biological tissue, having an illumination system, which is provided with at least one light source having a lamp system which generates incoherent light in a wavelength range of at least 380 to 680 nm, a light delivering unit which directs the light of said illumination system at the therapy and/or to-be-diagnosed tissue area, and an imaging, image-recording and image-transmitting unit which images the light coming from said tissue area in a proximal image plane.Type: GrantFiled: September 18, 1998Date of Patent: April 3, 2001Assignee: Karl Storz GmbH & Co., KGInventors: Klaus Irion, Reinhold Baumgartner, Herbert Stepp, André Ehrhardt, Karlheinz Strobl
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Patent number: 4920541Abstract: An apparatus for producing various laser wavelengths from the same laser medium by means of resonator mirrors. In accordance with the apparatus any desired, given combination of laser wavelengths can be brought to emission simultaneously or at least in very rapid alternation (switching time 1 ms) with the use of standard resonator mirrors linearly arranged outside of a laser medium, with part of at least one of the resonator mirrors being configured so that it serves as resonator limitation for a certain laser wavelength or wavelength group but another part of the at least one of the resonator mirrors constitutes an intracavity element for the respective other wavelength(s) or wavelength group(s).Type: GrantFiled: May 25, 1989Date of Patent: April 24, 1990Assignee: Gesellschaft fur Strahlenund Umweltforschung mbHInventors: Reinhold Baumgartner, Hans Lenz, Herbert Stepp, Eberhard Unsold