Abstract: An ambidextrous safety system for guns wherein such guns are adapted for efficient use by right or left-handed users. The safety system is adapted particularly for handguns, such as the Colt 0.45 caliber semi-automatic handgun, for example, but it is also quite well adapted for other types of guns as well. Manually actuated safety devices are positioned on each side of the frame of the gun and are adapted to be moved between safe and firing position. A pair of pivot pins, connected to each of the safety devices, extend through apertures in the frame of the gun and are nonrotatably connected by means of a mechanical interlock. The mechanical interlock is located within a close fitting bore of the frame, thus providing a structural stability therefor. A sear pin also extends through registering apertures in the frame by one of the safety devices.