Abstract: The present invention pertains to a new method for the diagnosis, prognosis, stratification and/or monitoring of a therapy, of cancer, preferably colorectal cancer (CRC), in a subject. The method is based on the determination of the level of a panel of least one, preferably 3, 4 and most preferably at least 5, protein biomarker selected from the group consisting of the protein biomarkers Amphiregulin (AREG), Carcinoembryonic antigen (CEA), Insulin like growth factor binding protein 2 (IGFBP2), Keratin, type I cytoskeletal 19 (KRT19), Mannan binding lectin serine protease 1 (MASP1), Osteopontin (OPN), Serum paraoxonase lactonase 3 (PON3) and Transferrin receptor protein 1 (TR), in the biological sample obtained from the subject. The new biomarker panel of the invention allows diagnosing and even stratifying various cancer diseases. Furthermore, provided are diagnostic kits for performing the non-invasive methods of the invention.

Abstract: The present invention relates to a method for determining a survival probability of a subject comprising a) detecting the methylation status of at least two CpG sites selected from the list consisting of cg24704287, cg08362785, cg25983901, cg06126421, cg05575921, cg23665802, cg01612140, cg19572487, cg14975410, and cg10321156 in a sample of said subject and, b) based on the methylation status detected in step a), determining the survival probability of said subject. The present invention further relates to uses, data collections, kits, devices and methods related to the aforesaid method.

Abstract: The present invention pertains to a new method for the diagnosis, prognosis, stratification and/or monitoring of a therapy, of cancer in a patient. The method is based on the determination of the level of a panel of biomarkers selected from CEA, AREG, IL-6, GDF-15, HGF-receptor, CXCL9, ErbB4-Her4, CXCL10, Flt3L, VEGFR-2, CD69, CXCL5, PSA, EMMPRIN, Cathepsin-D, Caspase-3, TNF-alpha, and INF-gamma. The new biomarker panel of the invention allows diagnosing and even stratifying various cancer diseases. Furthermore provided are diagnostic kits for performing the non-invasive methods of the invention.

Abstract: An in vitro method for the diagnosis, prognosis, stratification and/or monitoring of colorectal cancer in a subject includes detecting the level of AREG, CEA, HGF-receptor, ErbB4-Her4, CD69, PSA, EMMPRIN, and INF-gamma biomarkers in a biological sample of the subject. In an embodiment, the subject is administered a treatment when a differential level of the biomarkers compared to a healthy control or a reference value is indicative for the presence of colorectal cancer in the subject.

Abstract: The present invention pertains to a new method for the diagnosis, prognosis, stratification and/or monitoring of a therapy, of cancer in a patient. The method is based on the determination of the level of a panel of biomarkers selected from CEA, AREG, IL-6, GDF-15, HGF-receptor, CXCL9, ErbB4-Her4, CXCLIO, Flt3L, VEGFR-2, CD69, CXCL5S, PSA, EMMPRIN, Cathepsin-D, Caspase-3, TNF-alpha, and INF-gamma. The new biomarker panel of the invention allows diagnosing and even stratifying various cancer diseases. Furthermore provided are diagnostic kits for performing the non-invasive methods of the invention.

Abstract: A method and apparatus for grouping of objects such as books or the like to stacking layers for loading onto pallets wherein stacks of equal height are formed from the individual objects, and are conveyed sequentially for forming a stacking row, the length of which corresponds to the transverse dimension of a pallet; at least one of the stacks in a given stacking row is rotated by 90.degree. with respect to the other stacks in the given stacking row, and a gap is produced between the thusly rotated stack and the remainder of the stacks in the stacking row, the stacking row then being pushed onto an intermediate storage table, with subsequently arriving similarly oriented stacking rows being pushed onto the first stacking row to form a tier, and subsequent tiers similarly formed but with differently oriented stacks to provide a staggered or overlapping bond and thus a stable pallet stack.