Patents by Inventor Hermann Breuer

Hermann Breuer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-oxoazetidin-1-yloxy acetic acids and analogs
    Patent number: 4939253
    Abstract: Antibiotic activity is exhibited by .beta.-lactams having an ##STR1## substituent (and analogs thereof) in the 1-position and an acylamino substituent in the 3-position.
    Type: Grant
    Filed: July 21, 1983
    Date of Patent: July 3, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hermann Breuer, Henner Straub
  • 2-oxo-1-(((substituted sulfonyl)amino)-carbonyl)azetidines
    Patent number: 4801705
    Abstract: Antibacterial activity is exhibited by .beta.
    Type: Grant
    Filed: June 23, 1986
    Date of Patent: January 31, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hermann Breuer, Jakob-Matthias Drossard, Peter H. Ermann, Henner Straub, Uwe D. Treuner
  • 2-oxo-1-((Substituted sulfonyl)amino)-carbonyl)azetidines
    Patent number: 4772693
    Abstract: Antibacterial activity is exhibited by 2-azetidinones having a 3-acylamino substituted and having an activating group in the 1-position of the formula ##STR1## wherein A.sub.1 is a single bond, ##STR2## and A.sub.
    Type: Grant
    Filed: July 1, 1987
    Date of Patent: September 20, 1988
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Hermann Breuer
  • 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
    Patent number: 4762922
    Abstract: Antibacterial activity is exhibited by 2-azetidinones having a 3-acylamino substituent and having an activating group in the 1-position of the formula ##STR1## wherein R is ##STR2## A.sub.1 is --NH-- or ##STR3## A.sub.2 is ##STR4## or --CH.dbd.CH--.
    Type: Grant
    Filed: July 1, 1987
    Date of Patent: August 9, 1988
    Assignee: Squibb Corporation
    Inventors: Hermann Breuer, Uwe D. Treuner
  • 2-oxo-1-[[(substituted sulfonyl)amino]carbonyl]azetidines
    Patent number: 4743685
    Abstract: Antibacterial activity is exhibited by 2-azetidinones having a 3-acylamino substituent and having an activating group in the 1-position of the formula ##STR1##
    Type: Grant
    Filed: September 15, 1986
    Date of Patent: May 10, 1988
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hermann Breuer, Uwe D. Treuner, William H. Koster, Robert Zahler
  • 4-amino derivatives of 2-oxo-1-azetidinesulfonic acid salts
    Patent number: 4734496
    Abstract: .beta.-Lactams having a sulfonic acid salt substituent in the 1-position, an acylamino substituent in the 3-position and an --NR.sub.2 R.sub.3 substituent in the 4-position wherein R.sub.2 and R.sub.3 are the same or different and each is ##STR1## or R.sub.2 and R.sub.3 together with the nitrogen atom to which they are attached are ##STR2## R.sub.4 is alkyl, aryl or arylalkyl; and R.sub.5 and R.sub.6 are the same or different and each is hydrogen, halogen, alkyl, alkoxy, alkylthio, alkoxycarbonyl, carboxyl or a carboxyl salt; have antibacterial activity.
    Type: Grant
    Filed: May 29, 1981
    Date of Patent: March 29, 1988
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Uwe D. Treuner, Theodor Denzel, Hermann Breuer
  • 2-oxo-1-(aminocarbonylaminosulfonyl-aminocarbonyl)azetidines
    Patent number: 4670553
    Abstract: Antibacterial activity is exhibited by compounds having the formula ##STR1## and salts thereof, wherein R.sub.1 is acyl;R.sub.2 is hydrogen or methoxy;R.sub.3 and R.sub.4 are the same or different and each is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl or a 5,6 or 7-membered heterocycle or one of R.sub.3 and R.sub.4 is hydrogen and the other is azido, halomethyl, dihalomethyl, trihalomethyl, alkoxycarbonyl, 2-phenylethenyl, 2-phenylethynyl, carboxyl, ##STR2## X.sub.1 is azido, amino, hydroxy, alkanoylamino, alkylsulfonyloxy, arylsulfonyloxy, aryl, cyano, --S--X.sub.2 or --O--X.sub.2 ;X.sub.2 is alkyl, substituted alkyl, aryl, arylalkyl, alkanoyl, substituted alkanoyl, arylcarbonyl or heteroarylcarbonyl;one of X.sub.3 and X.sub.4 is hydrogen and the other is hydrogen or alkyl, or X.sub.3 and X.sub.4 when taken together with the carbon atom to which they are attached from a cycloalkyl group;X.sub.
    Type: Grant
    Filed: November 26, 1982
    Date of Patent: June 2, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hermann Breuer, Theodor Denzel
  • ((3-Acylamino-2-oxo-1-azetidinyl)oxy)methyl)phosphinic acids
    Patent number: 4670554
    Abstract: Antibacterial activity is exhibited by .beta.-lactams having a 3-acylamino substituent and in the 1-position a substituent having the formula ##STR1## wherein R.sub.5 and R.sub.6 are the same or different and each is hydrogen, alkyl, alkenyl, alkynyl, phenyl, substituted phenyl, cycloalkyl or a 4,5,6 or 7-membered heterocycle, or R.sub.5 and R.sub.6 together with the carbon atom to which they are attached are cycloalkyl or a 4,5,6 or 7-membered heterocycle, or one of R.sub.5 and R.sub.6 is hydrogen and the other is azido, halomethyl, dihalomethyl, trihalomethyl, alkoxycarbonyl, alkenyl, alkynyl, 2-phenylethenyl, 2-phenylethynyl, carboxyl, --CH.sub.2 X.sub.1, --S--X.sub.2, --O--X.sub.2, or ##STR2## R.sub.7 is hydrogen, alkyl, substituted alkyl, phenyl, substituted phenyl, 1-(ethoxycarbonyloxy)ethyl, 1,3-dihydro-3-oxo-1-isobenzofuranyl, ##STR3## wherein R' is hydrogen or alkyl, R" is alkyl or phenyl, R"' is hydrogen, methyl or phenyl, and R.sup.iv is hydrogen or together with R"' is --(CH.sub.2).sub.
    Type: Grant
    Filed: May 31, 1983
    Date of Patent: June 2, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: William H. Koster, Hermann Breuer
  • 3-acylamino-2-oxo-1-azetidinesulfonic acids
    Patent number: 4647660
    Abstract: Antibacterial activity is exhibited by 2-azetidinones activated in the 1-position with an --SO.sub.
    Type: Grant
    Filed: May 2, 1985
    Date of Patent: March 3, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Robert Zahler, Hermann Breuer, Glenn A. Jacobs
  • 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
    Patent number: 4587047
    Abstract: Antibacterial activity is exhibited by .beta.-lactams having a ##STR1## substituent in the 1-position and an acylamino substituent in the 3-position wherein Z is oxygen or sulfur, and R is alkyl, alkenyl, alkynyl, substituted alkyl, phenyl, substituted phenyl, a 5,6 or 7-membered heterocycle (R.sub.c), phenylalkyl, (substituted phenyl)alkyl, R.sub.c -alkyl or --NR.sub.a R.sub.b wherein R.sub.a and R.sub.b are the same or different and each is hydrogen, alkyl, substituted alkyl, phenyl, substituted phenyl, phenylalkyl, or (substituted phenyl)alkyl or one of R.sub.a and R.sub.b is hydrogen, alkyl, phenyl, substituted phenyl, phenylalkyl or (substituted phenyl)alkyl and the other is amino, alkanoylamino, arylcarbonylamino, alkoxycarbonylamino, alkylsulfonylamino, alkylamino, dialkylamino, phenylamino, (substituted phenyl)amino, hydroxy, cyano, alkoxy, phenyloxy, (substituted phenyl)oxy, phenylalkoxy, (substituted phenyl)alkoxy, R.sub.c, R.sub.c -alkyl, R.sub.
    Type: Grant
    Filed: April 1, 1982
    Date of Patent: May 6, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hermann Breuer, William A. Slusarchyk, Theodor Denzel, Uwe D. Treuner
  • 3-Acylamino-2-oxoazetidine-1-(.beta.-oxopropionic acid)
    Patent number: 4534896
    Abstract: Antibacterial activity and .beta.-lactamase inhibitory activity is exhibited by .beta.-lactams having a 3-acylamino substituent and in the 1-position a group having the formula ##STR1## wherein R.sub.5 is hydrogen, methyl or ethyl.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: August 13, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Uwe D. Treuner, Hermann Breuer
  • Iminothiazolyl ureido cephalosporins
    Patent number: 4501743
    Abstract: Cephalosporins of the formula ##STR1## wherein R is hydrogen, sodium, potassium or certain ester groups; R.sub.1 is in the .alpha.-configuration and is hydrogen or methoxy; R.sub.2 is hydrogen, ##STR2## X is hydrogen, ##STR3## R.sub.4 is hydrogen or lower alkyl; R.sub.5 is hydrogen, lower alkyl, ##STR4## --(CH.sub.2).sub.n --N--(lower alkyl).sub.2 ; R.sub.6 is hydrogen, sodium, or potassium; n is an integer from 1 to 4; are disclosed. These compounds are useful as anti-bacterial agents.
    Type: Grant
    Filed: March 12, 1984
    Date of Patent: February 26, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hermann Breuer, Uwe D. Treuner, Theodor Denzel
  • 2-Oxo-1-[(acylamino)sulfonyl]azetidines
    Patent number: 4499016
    Abstract: Antibacterial activity is exhibited by .beta.-lactams having an --SO.sub.2 --NH--C--R substituent in the 1-position and an acylamino substituent in the 3-position wherein R is alkyl, phenyl, substituted phenyl, phenylalkyl, (substituted phenyl)alkyl, alkoxy, phenyloxy, (substituted phenyl)oxy, phenylalkoxy, or (substituted phenyl)alkoxy.
    Type: Grant
    Filed: August 6, 1981
    Date of Patent: February 12, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hermann Breuer, Theodor Denzel, Uwe D. Treuner
  • Iminothiazolyl ureido cephalosporins
    Patent number: 4461767
    Abstract: Cephalosporins of the formula ##STR1## wherein R is hydrogen, sodium, potassium or certain ester groups; R.sub.1 is in the .alpha.-configuration and is hydrogen or methoxy; R.sub.2 is hydrogen, ##STR2## R.sub.4 is hydrogen or lower alkyl; R.sub.5 is hydrogen, lower alkyl, ##STR3## or --(CH.sub.2).sub.n --N--(lower alkyl).sub.2 ; R.sub.6 is hydrogen, sodium, or potassium; n is an integer from 1 to 4; are disclosed. These compounds are useful as anti-bacterial agents.
    Type: Grant
    Filed: June 6, 1979
    Date of Patent: July 24, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hermann Breuer, Uwe D. Treuner, Theodor Denzel
  • Cephalosporins having an imino substituted piperazindioncarbonylamino acyl sidechain
    Patent number: 4386199
    Abstract: Cephalosporins of the formula ##STR1## wherein R is hydrogen, sodium, potassium, or certain ester groups; R.sub.1 is in the .alpha.-configuration and is hydrogen or methoxy; R.sub.2 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, substituted or unsubstituted phenyl, benzyl, phenethyl, thienyl, furyl, or pyridyl, or 2-amino-4-thiazolyl; R.sub.3 is lower alkyl or substituted or unsubstituted phenyl, benzyl, phenethyl, thienyl, or furyl; R.sub.4 is hydrogen or lower alkyl; and X is hydrogen, ##STR2## --O--lower alkyl, or certain substituted or unsubstituted heterothio groups; are disclosed. These compounds possess useful antibacterial activity.
    Type: Grant
    Filed: May 4, 1981
    Date of Patent: May 31, 1983
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Uwe D. Treuner, Hermann Breuer
  • Aminothiazolyl ureido sulfoxide cephalosporins
    Patent number: 4275062
    Abstract: Cephalosporins of the formula ##STR1## R represents hydrogen, sodium, potassium, or certain ester groups, R.sub.1 is in the .alpha.-configuration and is hydrogen or methoxy, X represents hydrogen ##STR2## R.sub.3 represents hydrogen or lower alkyl, R.sub.4 is hydrogen, lower alkyl, ##STR3## or --(CH.sub.2).sub.n --N--(lower alkyl).sub.2, R.sub.5 represents hydrogen, sodium or potassium, and n represents an integer from 1 to 4. These compounds are useful as antibacterial agents.
    Type: Grant
    Filed: September 19, 1979
    Date of Patent: June 23, 1981
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hermann Breuer, Theodore Denzel, Uwe D. Treuner
  • Imidazole derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins
    Patent number: 4271157
    Abstract: A compound of the formula ##STR1## wherein R is hydrogen, alkali metal, ##STR2## R.sub.1 is hydrogen or methyl; R.sub.2 is hydrogen or methyl;R.sub.3 is hydrogen or methyl;R.sub.4 is hydrogen, --OCONH.sub.2, ##STR3## R.sub.5 is hydrogen or methyl;R.sub.6 is hydrogen, methyl, benzyl or acetyl;R.sub.7 is hydrogen or lower alkyl;R.sub.8 is hydrogen or --CONH.sub.2 ;R.sub.9 is hydrogen, lower alkyl, ##STR4## or --(CH.sub.2).sub.p --N--(lower alkyl).sub.2 ; R.sub.10 is hydrogen or lower alkyl;R.sub.11 is hydrogen, sodium or potassium;n is 1, 2, 3 or 4;m is 0, 1 or 2;p is 1, 2, 3 or 4.
    Type: Grant
    Filed: February 28, 1980
    Date of Patent: June 2, 1981
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Theodor Denzel, Hermann Breuer
  • Hydroxamic acid derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins
    Patent number: 4252802
    Abstract: A compound of the formula ##STR1## wherein R is hydrogen, alkali metal, ##STR2## or ##STR3## R.sub.1 is hydrogen or methyl; R.sub.2 is hydrogen or methyl;R.sub.3 is hydrogen, lower alkyl or lower alkylphenyl;R.sub.4 is hydrogen, --OCONH.sub.2, ##STR4## R.sub.7 is hydrogen or lower alkyl; R.sub.8 is hydrogen or --CONH.sub.2 ;R.sub.9 is hydrogen, lower alkyl, ##STR5## or --(CH.sub.2).sub.p --N--(lower alkyl).sub.2 ; R.sub.10 is hydrogen or lower alkyl;R.sub.11 is hydrogen, sodium or potassium;n is 1, 2, 3 or 4;m is 0, 1 or 2;p is 1, 2, 3 or 4.
    Type: Grant
    Filed: March 13, 1980
    Date of Patent: February 24, 1981
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Theodor Denzel, Hermann Breuer
  • Cephalosporins having an oxazolidonyloxamido substituted acyl sidechain
    Patent number: 4217348
    Abstract: Cephalosporins of the formula ##STR1## wherein R is hydrogen, sodium, potassium, or certain ester groups; R.sub.1 is in the .alpha.-configuration and is hydrogen or methoxy; R.sub.2 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, substituted or unsubstituted phenyl, benzyl, phenethyl, thienyl, furyl, or pyridyl, or 2-amino-4-thiazolyl; X is --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --, ##STR2## R.sub.3 is hydrogen, ##STR3## --O--lower alkyl, or certain substituted or unsubstituted heterothio groups; are disclosed. These compounds possess useful antibacterial activity.
    Type: Grant
    Filed: September 28, 1978
    Date of Patent: August 12, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Uwe D. Treuner, Hermann Breuer
  • Penicillins having an imino substituted piperazindioncarbonylamino acyl sidechain
    Patent number: 4189482
    Abstract: Penicillins of the formula ##STR1## wherein R is hydrogen , sodium, potassium or certain ester groups; R.sub.1 is in the .alpha.-configuration and is hydrogen or methoxy; R.sub.2 is hydrogen, lower aklkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, substituted or unsubstituted phenyl, benzyl, phenethyl, thienyl, furyl, or pyridyl, or 2-amino-4-thiazolyl; R.sub.3 is lower alkyl or substituted or unsubstituted phenyl, benzyl, phenethyl, thienyl or furyl; and R.sub.4 is hydrogen or lower alkyl; are disclosed. These compounds possess useful antibacterial activity.
    Type: Grant
    Filed: October 12, 1978
    Date of Patent: February 19, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Uwe D. Truener, Hermann Breuer