Abstract: The invention relates to methods for the diagnosis and prognosis of hepatic disorder and associated pathologies as well as of a solid proliferative disorder in a mammalian subject. More specifically, the methods of the invention are based on determining the expression, methylation of ARTS as well as histone trimethylation. The invention further provides therapeutic methods for treating said disorders.

Abstract: Pro-apoptotic compounds having a tripartite structure: A-L-B are disclosed. In these compounds A is an IBM mimetic moiety; L is a linker and B is a moiety that binds to a protein on the outer mitochondrial membrane. The compounds are useful for inducing cell apoptosis and therefore treating cancer.

Abstract: Pro-apoptotic compounds having a tripartite structure: A-L-B are disclosed. In these compounds A is an IBM mimetic moiety; L is a linker and B is a moiety that binds to a protein on the outer mitochondrial membrane. The compounds are useful for inducing cell apoptosis and therefore treating cancer.

Abstract: The present invention provides novel peptides, nucleic acids, compounds, compositions and methods for regulating apoptosis, and screening methods for identifying same. Regulation of apoptosis is mediated via IAPi-derived proteins, peptide fragments thereof, and nucleic acids encoding same, stimulating/accelerating or downmodulating/suppressing apoptosis. For stimulation/acceleration of apoptosis, the IAPi-derived proteins or peptide fragments thereof comprise RHG and Trp-box amino acid consensus sequences. Stimulation/acceleration results in self-ubiquitination and auto-degradation of an IAP. For downmodulation/suppression of apoptosis, IAPi-derived proteins or peptide fragments thereof comprising either RHG or Trp-box amino acid consensus sequences, or both, failing to stimulate or suppressing self-ubiquitination and auto-degradation of an IAP, result in suppression of apoptosis.

Abstract: The present invention provides novel peptides, nucleic acids, compounds, compositions and methods for regulating apoptosis, and screening methods for identifying same. Regulation of apoptosis is mediated via IAPi-derived proteins, peptide fragments thereof, and nucleic acids encoding same, stimulating/accelerating or downmodulating/suppressing apoptosis. For stimulation/acceleration of apoptosis, the IAPi-derived proteins or peptide fragments thereof comprise RHG and Trp-box amino acid consensus sequences. Stimulation/acceleration results in self-ubiquitination and auto-degradation of an IAP. For downmodulation/suppression of apoptosis, IAPi-derived proteins or peptide fragments thereof comprising either RHG or Trp-box amino acid consensus sequences, or both, failing to stimulate or suppressing self-ubiquitination and auto-degradation of an IAP, result in suppression of apoptosis.

Abstract: The present invention provides novel peptides, nucleic acids, compounds, compositions and methods for regulating apoptosis, and screening methods for identifying same. Regulation of apoptosis is mediated via IAPi-derived proteins, peptide fragments thereof, and nucleic acids encoding same, stimulating/accelerating or downmodulating/suppressing apoptosis. For stimulation/acceleration of apoptosis, the IAPi-derived proteins or peptide fragments thereof comprise RHG and Trp-box amino acid consensus sequences. Stimulation/acceleration results in self-ubiquitination and auto-degradation of an IAP. For downmodulation/suppression of apoptosis, IAPi-derived proteins or peptide fragments thereof comprising either RHG or Trp-box amino acid consensus sequences, or both, failing to stimulate or suppressing self-ubiquitination and auto-degradation of an IAP, result in suppression of apoptosis.

Abstract: The present invention provides methods for the regulation of spermatid differentiation. This invention also provides applications of regulated spermatid differentiation, including the treatment of infertility, contraception and pest control. This invention also describes agents for effecting such methods and compositions comprising same.

Abstract: Nucleotide acid sequences and corresponding translated products of novel mutant forms of the Drosophila DIAP1 gene are described. Such sequences and products are useful in screening methods for identifying and testing agonists and antagonists of DIAP1.

Abstract: Nucleic acid sequences and corresponding translated products of novel mutant forms of the Drosophila hid gene are described. Such sequences and products are useful in screening methods for identifying and testing antagonists of Hid phosphorylation, in particular, compositions modifying MAPK phosphorylation of Hid.

Abstract: The present invention relates to cell death genes, which are genes required for programmed cell deaths; mutant organisms, in which embryonic programmed cell death occurs to a less than normal extent; proteins encoded by the cell death genes; antibodies which bind the cell death gene products; and agents which alter the ability of cell death genes to cause programmed death of cells. As described herein, Applicants have identified two genes which function in the initiation of apoptosis or programmed cell death. These two genes, referred to respectively as the reaper (rpr) gene and the head involution defective (hid) gene, map to position 75C1,2 on the third chromosome in Drosophila (D.) melanogaster and, as described in detail below, exhibit expression patterns related to the pattern of cell death during Drosophila embryogenesis; mutations in each gene reduce levels of cell deaths or abolish cell death.