Patents by Inventor Hetal Parekh-Olmedo

Hetal Parekh-Olmedo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • G-rich polynucleotides for the treatment of Huntington's Disease
    Patent number: 7807648
    Abstract: The present invention relates to oligonucleotide compositions and therapeutic uses thereof to modify protein-protein interactions. In particular, the invention relates to the use of a guanidine-rich oligonucleotides to disrupt disease-causing protein aggregates, for example, Huntington's Disease (HD) protein aggregates.
    Type: Grant
    Filed: October 6, 2006
    Date of Patent: October 5, 2010
    Assignee: University of Delaware
    Inventors: Eric B. Kmiec, Hetal Parekh-Olmedo
  • Enhanced oligonucleotide-mediated nucleic acid sequence alteration
    Patent number: 7566535
    Abstract: The invention is directed to oligonucleotide-mediated repair or alteration of genetic information, such as nucleic acid sequence alteration, and methods, compositions and kits for enhancing the efficiency of such alteration. Specifically, the invention incorporates the use of factors such as Histone Deacetylase Inhibitor (HDAC), Lambda phage beta protein, or hydroxyurea to achieve such enhanced efficiency.
    Type: Grant
    Filed: March 7, 2003
    Date of Patent: July 28, 2009
    Assignee: University of Delaware
    Inventors: Eric B. Kmiec, Hetal Parekh-Olmedo, Erin E. Brachman
  • Guanosine rich oligonucleotides and methods of inducing apoptosis in tumor cells
    Publication number: 20080096838
    Abstract: Presently described is a guanosine-rich polynucleotide molecule with therapeutic utility for treating or preventing the growth of cancerous cells. In addition, a method of retarding cell cycle progression and inducing apoptosis in tumor cells using synthetic oligonucleotides is also described.
    Type: Application
    Filed: August 7, 2007
    Publication date: April 24, 2008
    Inventors: Eric Kmiec, Hetal Parekh-Olmedo, Timothy Schwartz
  • G-rich polynucleotides as a novel therapeutic for the treatment of huntington's disease
    Publication number: 20080051363
    Abstract: The present invention relates to oligonucleotide compositions and therapeutic uses thereof to modify protein-protein interactions.
    Type: Application
    Filed: July 16, 2007
    Publication date: February 28, 2008
    Inventors: Eric Kmiec, Hetal Parekh-Olmedo
  • G-rich polynucleotides for the treatment of huntington's disease
    Publication number: 20070105805
    Abstract: The present invention relates to oligonucleotide compositions and therapeutic uses thereof to modify protein-protein interactions.
    Type: Application
    Filed: October 6, 2006
    Publication date: May 10, 2007
    Inventors: Eric Kmiec, Hetal Parekh-Olmedo
  • Methods and kits to increase the efficiency of oligonucleotide-directed nucleic acid sequence alteration
    Publication number: 20070072815
    Abstract: Methods, kits and cell lines are presented for effecting oligonucleotide-directed genetic alteration at a specific locus in a target DNA molecule in a population of cells at increased efficiency.
    Type: Application
    Filed: May 3, 2005
    Publication date: March 29, 2007
    Inventors: Eric Kmiec, Hetal Parekh-Olmedo, Luciana Ferrara, Erin Brachman
  • Compositions and methods for the treatment of diseases exhibiting protein misassembly and aggregation
    Publication number: 20040096880
    Abstract: Compounds, compositions, and pharmaceutical compositions comprising oligonucleotides capable of disrupting protein aggregations that are characteristic of disorders of protein assembly are described, as are in vitro and in vivo methods for identifying usch oligonucleotides, and methods for treating such disorders by administration of such compositions.
    Type: Application
    Filed: August 7, 2003
    Publication date: May 20, 2004
    Inventors: Eric B. Kmiec, Hetal Parekh-Olmedo
  • Methods, compositions, and kits for enhancing oligonucleotide-mediated nucleic acid sequence alteration using compositions comprising a histone deacetylase inhibitor, lambda phage beta protein, or hydroxyurea
    Publication number: 20030207451
    Abstract: Improved methods, compositions, and kits for oligonucleotide-mediated nucleic acid sequence alteration are presented.
    Type: Application
    Filed: March 7, 2003
    Publication date: November 6, 2003
    Inventors: Eric B. Kmiec, Hetal Parekh-Olmedo, Erin E. Brachman
  • Compositions and methods for the prevention and treatment of Huntington's disease
    Publication number: 20030109476
    Abstract: The present invention provides compositions and methods for the prevention and treatment of a neurodegenerative disease, specifically Huntington's disease. In particular, the invention provides single-stranded, modified oligonucleotides for the targeted alteration of the genetic sequence of the Huntington's disease gene, and mehods of treating or preventing Huntington's disease using the same.
    Type: Application
    Filed: August 7, 2002
    Publication date: June 12, 2003
    Inventors: Eric B. Kmiec, Hetal Parekh-Olmedo