Patents by Inventor Hetal Sarvaiya

Hetal Sarvaiya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sialylated Glycoproteins
    Publication number: 20240167069
    Abstract: Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.
    Type: Application
    Filed: July 6, 2023
    Publication date: May 23, 2024
    Inventors: Naveen Bhatnagar, Robin Meccariello, Jonathan C. Lansing, Daniel Ortiz, Hetal Sarvaiya, Nathaniel J. Washburn
  • Sialylated Glycoproteins
    Publication number: 20240141401
    Abstract: Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.
    Type: Application
    Filed: June 30, 2023
    Publication date: May 2, 2024
    Inventors: Naveen Bhatnagar, Robin Meccariello, Jonathan C. Lansing, Daniel Ortiz, Hetal Sarvaiya, Nathaniel J. Washburn
  • GLYCOPROTEINS WITH ANTI-INFLAMMATORY PROPERTIES
    Publication number: 20220056109
    Abstract: Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.
    Type: Application
    Filed: October 22, 2021
    Publication date: February 24, 2022
    Inventors: Hetal Sarvaiya, Nathaniel J. Washburn, Enrique Arevalo, Carlos J. Bosques
  • Sialylated Glycoproteins
    Publication number: 20210277438
    Abstract: Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.
    Type: Application
    Filed: November 20, 2020
    Publication date: September 9, 2021
    Inventors: Naveen Bhatnagar, Robin Meccariello, Jonathan C. Lansing, Daniel Ortiz, Hetal Sarvaiya, Nathaniel J. Washburn
  • Methods and Compositions for the Diagnosis and Treatment of Kawasaki Disease
    Publication number: 20210116462
    Abstract: The present invention relates to the determination of levels or expression of particular biomarkers in biological samples which can be utilized to diagnose, prognose, and treat Kawasaki disease in subjects, and further to select subjects who would benefit from a Kawasaki disease therapy other than, or in addition to, IVIG treatment. Accordingly, the present invention encompasses methods and compositions that utilize these biomarkers for the diagnosis, prognosis, and treatment of Kawasaki disease.
    Type: Application
    Filed: April 6, 2020
    Publication date: April 22, 2021
    Inventors: Dorota A. Bulik, Carlos J. Bosques, Jay Duffner, Leona E. Ling, Hetal Sarvaiya
  • Sialylated Glycoproteins
    Publication number: 20210040527
    Abstract: Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.
    Type: Application
    Filed: September 25, 2020
    Publication date: February 11, 2021
    Inventors: Naveen Bhatnagar, Robin Meccariello, Jonathan C. Lansing, Daniel Ortiz, Hetal Sarvaiya, Nathaniel J. Washburn
  • Sialylated Glycoproteins
    Publication number: 20210017563
    Abstract: Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.
    Type: Application
    Filed: September 25, 2020
    Publication date: January 21, 2021
    Inventors: Naveen Bhatnagar, Robin Meccariello, Jonathan C. Lansing, Daniel Ortiz, Hetal Sarvaiya, Nathaniel J. Washburn
  • SIALYLATED GLYCOPROTEINS
    Publication number: 20200032312
    Abstract: Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.
    Type: Application
    Filed: October 1, 2019
    Publication date: January 30, 2020
    Inventors: Naveen Bhatnagar, Robin Meccariello, Jonathan C. Lansing, Daniel Ortiz, Hetal Sarvaiya, Nathaniel J. Washburn
  • Sialylated Glycoproteins
    Publication number: 20180305725
    Abstract: Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.
    Type: Application
    Filed: April 16, 2018
    Publication date: October 25, 2018
    Inventors: Naveen Bhatnagar, Robin Meccariello, Jonathan C. Lansing, Daniel Ortiz, Hetal Sarvaiya, Nathaniel Washburn
  • GLYCOPROTEINS WITH ANTI-INFLAMMATORY PROPERTIES
    Publication number: 20180305440
    Abstract: Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.
    Type: Application
    Filed: April 19, 2018
    Publication date: October 25, 2018
    Inventors: Hetal Sarvaiya, Nathaniel J. Washburn, Enrique Arevalo, Carlos J. Bosques
  • Galactose-alpha-1, 3-galactose-containing n-glycans in glycoprotein products derived from CHO cells
    Patent number: 10023894
    Abstract: Methods of producing recombinant therapeutic fusion proteins described herein can include culturing Chinese hamster ovary (CHO) cells under conditions suitable for expression of a recombinant therapeutic fusion protein including one or more glycans, where the CHO cells have not been genetically engineered to produce terminal alpha-galactosyl residues on glycans; treating the one or more glycans of the recombinant glycoprotein with one or more exoglycosidases; measuring glycans containing terminal galactose-alpha-1-3-galactose residues on the fusion protein by nuclear magnetic resonance (NMR); and producing a recombinant therapeutic fusion protein in the CHO cells if a target level of terminal galactose-alpha-1-3-galactose residues is measured.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: July 17, 2018
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Carlos J. Bosques, Jennifer Murphy, Hetal Sarvaiya, Nathaniel Washburn, Cuihua Liu, Xiao-Jin Xu
  • METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF KAWASAKI DISEASE
    Publication number: 20170052200
    Abstract: The present invention relates to the determination of levels or expression of particular biomarkers in biological samples which can be utilized to diagnose, prognose, and treat Kawasaki disease in subjects, and further to select subjects who would benefit from a Kawasaki disease therapy other than, or in addition to, IVIG treatment. Accordingly, the present invention encompasses methods and compositions that utilize these biomarkers for the diagnosis, prognosis, and treatment of Kawasaki disease.
    Type: Application
    Filed: May 1, 2015
    Publication date: February 23, 2017
    Inventors: Dorota A. BULIK, Jay DUFFNER, Leona E. LING, Hetal SARVAIYA, Carlos J. BOSQUES
  • SIALYLATED GLYCOPROTEINS
    Publication number: 20160108450
    Abstract: Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.
    Type: Application
    Filed: May 1, 2014
    Publication date: April 21, 2016
    Inventors: Naveen BHATNAGAR, Robin MECCARIELLO, Jonathan C. LANSING, Daniel ORTIZ, Hetal SARVAIYA, Nathaniel WASHBURN
  • GALACTOSE-ALPHA-1, 3-GALACTOSE-CONTAINING N-GLYCANS IN GLYCOPROTEIN PRODUCTS DERIVED FROM CHO CELLS
    Publication number: 20160053292
    Abstract: The present invention provides methods of evaluating CHO cells.
    Type: Application
    Filed: August 21, 2015
    Publication date: February 25, 2016
    Inventors: Carlos J. Bosques, Jennifer Murphy, Hetal Sarvaiya, Nathaniel Washburn, Cuihua Liu, Xiao-Jin Xu
  • GLYCOPROTEINS WITH ANTI-INFLAMMATORY PROPERTIES
    Publication number: 20150210753
    Abstract: Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.
    Type: Application
    Filed: July 25, 2013
    Publication date: July 30, 2015
    Applicant: Momenta Pharmaceuticals, Inc.
    Inventors: Hetal Sarvaiya, Nathaniel Washburn, Enrique Arevalo, Carlos J. Bosques
  • GAL ALPHA 1-3GAL-CONTAINING N-GLYCANS IN GLYCOPROTEIN PRODUCTS DERIVED FROM CHO CELLS
    Publication number: 20140045212
    Abstract: The present invention provides methods of evaluating CHO cells.
    Type: Application
    Filed: October 17, 2013
    Publication date: February 13, 2014
    Applicant: Momenta Pharmaceuticals, Inc.
    Inventors: Carlos J. Bosques, Jennifer Murphy, Hetal Sarvaiya, Nathaniel Washburn, Cuihua Liu, Xiao-Jin Xu
  • Gal ?1-3gal-containing N-glycans in glycoprotein products derived from CHO cells
    Patent number: 8586356
    Abstract: The present invention provides methods of evaluating CHO cells.
    Type: Grant
    Filed: January 22, 2009
    Date of Patent: November 19, 2013
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Carlos Bosques, Jennifer Murphy, Hetal Sarvaiya, Nathaniel Washburn, Cuihua Liu, Xiao-Jin Xu
  • ISOTOPICALLY-LABELED GLYCANS
    Publication number: 20110213137
    Abstract: The present disclosure provides methods of making isotopically-labeled glycans or a mixture of glycans (e.g., a glycan preparation) via reductive amination. Such methods are useful, for example, in the determination of the relative amounts of a glycan species present in two or more glycoprotein preparations using mass spectroscopy. In one aspect, the present disclosure provides a method of making an isotopically-labeled glycan by a glycan with an amine and an isotopically-labeled reducing agent to provide an isotopically-labeled aminated glycan. In certain embodiments, the amine is an isotopically-labeled amine.
    Type: Application
    Filed: April 15, 2008
    Publication date: September 1, 2011
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Carlos J. Bosques, Ian Christopher Parsons, Lakshmanan Thiruneelakantapillai, Brian Edward Collins, Hetal Sarvaiya
  • GAL ALPHA 1-3GAL-CONTAINING N-GLYCANS IN GLYCOPROTEIN PRODUCTS DERIVED FROM CHO CELLS
    Publication number: 20110045496
    Abstract: The present invention provides methods of evaluating CHO cells.
    Type: Application
    Filed: January 22, 2009
    Publication date: February 24, 2011
    Inventors: Carlos Bosques, Jennifer Murphy, Hetal Sarvaiya, Nathaniel Washburn, Cuihua Liu, Xiao-Jin Xu