Patents by Inventor Hexin Xie

Hexin Xie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2,7-disubstituted cephalosporin derivatives as ?-lactamase substrates and methods for their use for the diagnosis of tuberculosis
    Patent number: 10344165
    Abstract: ?-Lactamase substrates and methods for using the substrates to detect ?-lactamase and to diagnose tuberculosis.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: July 9, 2019
    Assignees: The Texas A&M University System, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jianghong Rao, Hexin Xie, Yunfeng Cheng, Jeffrey D. Cirillo
  • 2,7-DISUBSTITUTED CEPHALOSPORIN DERIVATIVES AS BETA-LACTAMASE SUBSTRATES AND METHODS FOR THEIR USE FOR THE DIAGNOSIS OF TUBERCULOSIS
    Publication number: 20180094139
    Abstract: ?-Lactamase substrates and methods for using the substrates to detect ?-lactamase and to diagnose tuberculosis.
    Type: Application
    Filed: December 4, 2017
    Publication date: April 5, 2018
    Applicants: The Texas A&M University System, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jianghong Rao, Hexin Xie, Yunfeng Cheng, Jeffrey D. Cirillo
  • 2,7-disubstituted cephalosporin derivatives as beta-lactamase substrates and methods for their use for the diagnosis of tuberculosis
    Patent number: 9834681
    Abstract: ?-Lactamase substrates and methods for using the substrates to detect ?-lactamase and to diagnose tuberculosis.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: December 5, 2017
    Assignees: The Texas A&M University System, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jianghong Rao, Hexin Xie, Yunfeng Cheng, Jeffrey D. Cirillo
  • ?-lactamase substrates and methods of their use for the diagnosis of tuberculosis
    Patent number: 9677112
    Abstract: ?-Lactamase substrates and methods for using the substrates to detect ?-lactamase diagnose tuberculosis.
    Type: Grant
    Filed: May 15, 2013
    Date of Patent: June 13, 2017
    Assignees: The Texas A&M University System, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jianghong Rao, Jeffrey D. Cirillo, Hexin Xie, James C. Sacchettini
  • Use of bacterial beta-lactamase for in vitro diagnostics and in vivo imaging, diagnostics and therapeutics
    Patent number: 9138490
    Abstract: Provided herein are methods for detecting, quantifying, differentiating, diagnosing and imaging pathogenic bacteria or condition associated therewith using substrates for bacterial enzymes. Fluorescent, luminescent or colorimetric signals emitted by substrates or enzyme products in the presence of the bacteria are compared to controls to detect and locate the pathogenic bacteria. Provided is a method for screening therapeutic agents to treat the pathophysiological conditions by measuring a signal emitted from the substrates or products in the presence and absence of the potential therapeutic agent and a diagnostic method for detecting a mycobacterial infection in a subject by contacting biological samples with a substrate and imaging for signals emitted from a mycobacterial beta-lactamase product. Also provided are fluorogenic substrates or substrates comprising a colored dye or a chemical reagent effective to induce a color or pH change.
    Type: Grant
    Filed: December 4, 2012
    Date of Patent: September 22, 2015
    Assignees: The Texas A&M University System, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jeffrey D. Cirillo, James C. Sacchettini, Jianghong Rao, Hexin Xie
  • 2,7-DISUBSTITUTED CEPHALOSPORIN DERIVATIVES AS BETA-LACTAMASE SUBSTRATES AND METHODS FOR THEIR USE FOR THE DIAGNOSIS OF TUBERCULOSIS
    Publication number: 20150219653
    Abstract: ?-Lactamase substrates and methods for using the substrates to detect ?-lactamase and to diagnose tuberculosis.
    Type: Application
    Filed: February 3, 2015
    Publication date: August 6, 2015
    Applicants: The Texas A&M University System, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jianghong Rao, Hexin Xie, Yunfeng Cheng, Jeffrey D. Cirillo
  • BETA-LACTAMASE SUBSTRATES AND METHODS OF THEIR USE FOR THE DIAGNOSIS OF TUBERCULOSIS
    Publication number: 20150167048
    Abstract: ?-Lactamase substrates and methods for using the substrates to detect ?-lactamase diagnose tuberculosis.
    Type: Application
    Filed: May 15, 2013
    Publication date: June 18, 2015
    Applicants: The Texas A&M University System, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jianghong Rao, Jeffrey D. Cirillo, Hexin Xie, James C. Sacchettini
  • USE OF BACTERIAL BETA-LACTAMASE FOR IN VITRO DIAGNOSTICS AND IN VIVO IMAGING, DIAGNOSTICS AND THERAPEUTICS
    Publication number: 20130164221
    Abstract: Provided herein are methods for detecting, quantifying, differentiating, diagnosing and imaging pathogenic bacteria or condition associated therewith using substrates for bacterial enzymes. Fluorescent, luminescent or colorimetric signals emitted by substrates or enzyme products in the presence of the bacteria are compared to controls to detect and locate the pathogenic bacteria. Provided is a method for screening therapeutic agents to treat the pathophysiological conditions by measuring a signal emitted from the substrates or products in the presence and absence of the potential therapeutic agent and a diagnostic method for detecting a mycobacterial infection in a subject by contacting biological samples with a substrate and imaging for signals emitted from a mycobacterial beta-lactamase product. Also provided are fluorogenic substrates or substrates comprising a colored dye or a chemical reagent effective to induce a color or pH change.
    Type: Application
    Filed: December 4, 2012
    Publication date: June 27, 2013
    Inventors: Jeffrey D. Cirillo, James C. Sacchettini, Jianghong Rao, Hexin Xie
  • Use of bacterial beta-lactamase for in vitro diagnostics and in vivo imaging, diagnostics and therapeutics
    Publication number: 20110020240
    Abstract: Provided herein are imaging methods for detecting, diagnosing and imaging pathogenic bacteria or a pathophysiological condition associated therewith using fluorogenic substrates for bacterial enzymes. Fluorescent, luminescent or colorimetric signals emitted by substrates or enzyme products in the presence of the bacteria are compared to controls to detect and locate the pathogenic bacteria. Provided is a method for screening therapeutic agents to treat the pathophysiological conditions by measuring a signal emitted from the fluorogenic substrates or products in the presence and absence of the potential therapeutic agent. In addition, a diagnostic method for detecting a mycobacterial infection in a subject by contacting biological samples with a fluorogenic substrate and imaging for signals emitted from a mycobacterial beta-lactamase product.
    Type: Application
    Filed: June 4, 2010
    Publication date: January 27, 2011
    Inventors: Jeffrey D. Cirillo, James C. Sacchettini, Jianghong Rao, Hexin Xie