Patents by Inventor Hideaki Muratake

Hideaki Muratake has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9353134
    Abstract: A compound represented by the formula (I) [at least one of R1, R2, and R3 represents a cyclic alkyl group, the remaining represents a linear or branched alkyl group; n represents 0 or 1; R4 represents an amino group or —(CX2)m—COOH (m represents 0 to 3, and X represents hydrogen atom); and R5 represents —(CY2)p—COOR6 (p represents 0 to 3, Y represents hydrogen atom, and R6 represents hydrogen atom or an alkyl group)], or a salt thereof.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: May 31, 2016
    Assignee: KEMPHYS LTD.
    Inventors: Hideaki Muratake, Ai Ito, Koichi Shudo
  • Publication number: 20150232487
    Abstract: A compound represented by the formula (I) [at least one of R1, R2, and R3 represents a cyclic alkyl group, the remaining represents a linear or branched alkyl group; n represents 0 or 1; R4 represents an amino group or —(CX2)m—COOH (m represents 0 to 3, and X represents hydrogen atom); and R5 represents —(CY2)p—COOR6 (p represents 0 to 3, Y represents hydrogen atom, and R6 represents hydrogen atom or an alkyl group)], or a salt thereof.
    Type: Application
    Filed: October 17, 2013
    Publication date: August 20, 2015
    Applicant: KEMPHYS LTD.
    Inventors: Hideaki Muratake, Ai Ito, Koichi Shudo
  • Patent number: 8895769
    Abstract: A compound represented by the formula (I) [R1 to R3 represent an alkyl group, an alkenyl group, and the like; n represents 0 or 1; R4 represents an amino group or —(CX2)m—COOH (m represents 0 to 3, and X represents hydrogen atom); R5 represents —(CY2)p—COOR6 (p represents an 0 to 3, Y represents hydrogen atom, and R6 represents hydrogen atom or an alkyl group)], or a salt thereof.
    Type: Grant
    Filed: April 19, 2012
    Date of Patent: November 25, 2014
    Assignee: Kemphys Ltd.
    Inventors: Hideaki Muratake, Ai Ito, Koichi Shudo
  • Patent number: 8722730
    Abstract: A compound represented by the following general formula (I): [wherein R1 and R2 represent an alkyl group, X represents —S—, —O— or —NH—, Y represents C or N, R3 represents hydrogen atom or a C1-10 alkyl group, Z represents —CO—N(R5)— (R5 represents hydrogen atom or a C1-6 alkyl group) or —C(R6)?C(R7)—CO—NH— (R6 and R7 represent hydrogen atom or a C1-6 alkyl group), Ar represents an aryldiyl group or a heteroaryldiyl group, and R4 represents —COOH, —OCH2—COOH, —CH2—COOH, or —CH2—CH2—COOH], which has a retinoid action and is useful as an active ingredient of a medicament.
    Type: Grant
    Filed: August 14, 2008
    Date of Patent: May 13, 2014
    Assignee: Research Foundation Itsuu Laboratory
    Inventors: Hideaki Muratake, Masayuki Noguchi, Koichi Shudo
  • Publication number: 20140121407
    Abstract: A compound corresponding to 3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]phenyl]propionic acid in which a part or all of hydrogen atoms in the ethylene group constituting the propionic acid moiety are replaced with deuterium atoms, a salt thereof, or an ester thereof, and a prodrug for releasing Am80 as an active medicament after being absorbed into a living body, which comprises the aforementioned compound, a salt thereof, or an ester thereof as an active ingredient.
    Type: Application
    Filed: July 4, 2012
    Publication date: May 1, 2014
    Applicant: RESEARCH FOUNDATION ITSUU LABORATORY
    Inventors: Hideaki Muratake, Koichi Shudo, Yohei Amano, Takahiro Toda
  • Publication number: 20140031575
    Abstract: A compound represented by the formula (I) [R1 to R8 represent an alkyl group, an alkenyl group, and the like; n represents 0 or 1; R4 represents an amino group or —(CX2)m—COOH (m represents 0 to 3, and X represents hydrogen atom); R5 represents —(CY2)p—COOR6 (p represents an 0 to 3, Y represents hydrogen atom, and R6 represents hydrogen atom or an alkyl group)], or a salt thereof.
    Type: Application
    Filed: April 19, 2012
    Publication date: January 30, 2014
    Applicants: KEMPHYS LTD., RESEARCH FOUNDATION ITSUU LABORATORY
    Inventors: Hideaki Muratake, Ai Ito, Koichi Shudo
  • Patent number: 8633335
    Abstract: A compound represented by the following general formula (I): [R1 to R5 represent hydrogen atom, an alkyl group, or a trialkylsilyl group, X represents —NH—CO—, —CO—NH—, —N(COR6)—CO—, —CO—N(COR7)— (R6 and R7 represent a lower alkoxy group, or a carboxy-substituted phenyl group) etc.; and Z represents —Y—CH(R12)—COOH, —CHO, —CH?CH—COOH, or —COOR13 (Y represents a single bond, —CH2—, —CH(OH)—, —CO—, —CO—NH—, or —CO—NH—CH2—CO—NH—, R12 represents hydrogen atom or a lower alkyl group, and R13 represents hydrogen atom, —CH(R14)—COOH(R14 represents hydrogen atom, a lower alkyl group, or hydroxy group), —[CH2CH2—O]n—CH2—CH2—OH, —CH2—O—[CH2CH2—O]m—CH2—OH, or —[CH(CH3)—CO—O]p—CH(CH3)—COOH (m, n and p represent an integer of 1 to 100))], a salt thereof or an ester thereof, which has a property of being converted into a retinoid after absorption in vivo.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: January 21, 2014
    Assignee: Research Founation Itsuu Laboratory
    Inventors: Hideaki Muratake, Koichi Shudo
  • Publication number: 20110213156
    Abstract: A compound represented by the following general formula (I): [wherein R1 and R2 represent an alkyl group, X represents —S—, —O— or —NH—, Y represents C or N, R3 represents hydrogen atom or a C1-10 alkyl group, Z represents —CO—N(R5)— (R5 represents hydrogen atom or a C1-6 alkyl group) or —C(R6)?C(R7)—CO—NH— (R6 and R7 represent hydrogen atom or a C1-6 alkyl group), Ar represents an aryldiyl group or a heteroaryldiyl group, and R4 represents —COOH, —OCH2—COOH, —CH2—COOH, or —CH2—CH2—COOH], which has a retinoid action and is useful as an active ingredient of a medicament.
    Type: Application
    Filed: August 14, 2008
    Publication date: September 1, 2011
    Applicant: RESEARCH FOUNDATION ITSUU LABORATORY
    Inventors: Hideaki Muratake, Masayuki Noguchi, Koichi Shudo
  • Publication number: 20100286427
    Abstract: A compound represented by the following general formula (I): [R1 to R5 represent hydrogen atom, an alkyl group, or a trialkylsilyl group, X represents —NH—CO—, —CO—NH—, —N(COR6)—CO—, —CO—N(COR7)— (R6 and R7 represent a lower alkoxy group, or a carboxy-substituted phenyl group) etc.; and Z represents —Y—CH(R12)—COOH, —CHO, —CH?CH—COOH, or —COOR13 (Y represents a single bond, —CH2—, —CH(OH)—, —CO—, —CO—NH—, or —CO—NH—CH2—CO—NH—, R12 represents hydrogen atom or a lower alkyl group, and R13 represents hydrogen atom, —CH(R14)—COOH(R14 represents hydrogen atom, a lower alkyl group, or hydroxy group), —[CH2CH2—O]n—CH2—CH2—OH, —CH2—O—[CH2CH2—O]m—CH2—OH, or —[CH(CH3)—CO—O]p—CH(CH3)—COOH (m, n and p represent an integer of 1 to 100))], a salt thereof or an ester thereof, which has a property of being converted into a retinoid after absorption in vivo.
    Type: Application
    Filed: October 31, 2007
    Publication date: November 11, 2010
    Applicant: RESEARCH FOUNDATION ITSUU LABORATORY
    Inventors: Hideaki Muratake, Koichi Shudo