Patents by Inventor Hideharu Mikami
Hideharu Mikami has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10890520Abstract: A flow cytometer including a flow cell in which an imaging object flows; a laser beam irradiator configured to radiate laser beam; a camera including an image sensor of N×M pixels; and an optical system configured to introduce the laser beam from the laser beam irradiator to imaging range of flow cell and to introduce signal light, such as transmitted, reflected or scattered light, from imaging range of flow cell, to camera. Optical system includes a mirror device that is placed on a Fourier plane of imaging optical system, that has at least one mirror specularly reflecting the signal light, and that is driven and rotated in conjunction with a flow in flow cell, such that each part of an image formed by the signal light is introduced into an identical pixel of the image sensor for at least a predetermined time period from a predetermined timing.Type: GrantFiled: September 5, 2017Date of Patent: January 12, 2021Assignee: THE UNIVERSITY OF TOKYOInventors: Keisuke Goda, Yasuyuki Ozeki, Hideharu Mikami
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Patent number: 10788655Abstract: Provided are an irradiation device, a laser microscope system, an irradiation method, and a laser microscope detection method which can further widen a bandwidth of detection light as a multiplexed signal. Laser light beams are separated and enter a first AOD (24) and a second AOD (34) so that a plurality of first diffracted light beams and a plurality of second diffracted light beams with deflection angles and sizes of frequency shifts different from each other are generated. The first diffracted light beams and the second diffracted light beams are superposed by a beam splitter (19) so as to generate a plurality of interference light beams with beat frequencies different from each other. An objective lens (52) is formed by aligning a plurality of irradiation spots of interference light beam linearly in a main scanning direction and irradiates a sample (T) with the interference light beam.Type: GrantFiled: February 9, 2017Date of Patent: September 29, 2020Assignee: Japan Science and Technology AgencyInventors: Hideharu Mikami, Keisuke Goda
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Patent number: 10620124Abstract: In a multi-color CARS microscope, it has been difficult to accurately bring optical axes of pump light and Stokes light into correspondence and to stably acquire a spectral signal. Accordingly, in an optical analysis device, CARS light is generated from, a sample by using a residual component of the pump light introduced to an optical waveguide and the Stokes light generated in an optical waveguide.Type: GrantFiled: October 20, 2014Date of Patent: April 14, 2020Assignee: HITACHI, LTD.Inventor: Hideharu Mikami
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Patent number: 10595770Abstract: A multiphoton microscope based on two-photon excited fluorescence and second-harmonic generation that images FOVs of about 0.8 mm2 (without stitching adjacent FOVs) at speeds of 10 frames/second (800×800 pixels) with lateral and axial resolutions of 0.5 ?m and 2.5 ?m, respectively. The scan head of the instrument includes a fast galvanometric scanner, relay optics, a beam expander and a high NA objective lens. The system is based on a 25×, 1.05 NA water immersion lens, which features a long working distance of 1 mm. A proper tailoring of the beam expander, which consists of the scan and tube lens elements, enables scaling of the FOV. The system and method also include a flat wavefront of the beam, minimum field curvature, and suppressed spherical aberrations. All aberrations in focus are below the Marechal criterion of 0.07? rms for diffraction-limited performance.Type: GrantFiled: October 17, 2017Date of Patent: March 24, 2020Assignee: The Regents of the University of CaliforniaInventors: Mihaela Balu, Eric O. Potma, Bruce J. Tromberg, Hideharu Mikami
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Publication number: 20190226976Abstract: A flow cytometer including a flow cell in which an imaging object flows; a laser beam irradiator configured to radiate laser beam; a camera including an image sensor of N×M pixels; and an optical system configured to introduce the laser beam from the laser beam irradiator to imaging range of flow cell and to introduce signal light, such as transmitted, reflected or scattered light, from imaging range of flow cell, to camera. Optical system includes a mirror device that is placed on a Fourier plane of imaging optical system, that has at least one mirror specularly reflecting the signal light, and that is driven and rotated in conjunction with a flow in flow cell, such that each part of an image formed by the signal light is introduced into an identical pixel of the image sensor for at least a predetermined time period from a predetermined timing.Type: ApplicationFiled: September 5, 2017Publication date: July 25, 2019Applicant: THE UNIVERSITY OF TOKYOInventors: Keisuke GODA, Yasuyuki OZEKI, Hideharu MIKAMI
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Publication number: 20190041620Abstract: Provided are an irradiation device, a laser microscope system, an irradiation method, and a laser microscope detection method which can further widen a bandwidth of detection light as a multiplexed signal. Laser light beams are separated and enter a first AOD (24) and a second AOD (34) so that a plurality of first diffracted light beams and a plurality of second diffracted light beams with deflection angles and sizes of frequency shifts different from each other are generated. The first diffracted light beams and the second diffracted light beams are superposed by a beam splitter (19) so as to generate a plurality of interference light beams with beat frequencies different from each other. An objective lens (52) is formed by aligning a plurality of irradiation spots of interference light beam linearly in a main scanning direction and irradiates a sample (T) with the interference light beam.Type: ApplicationFiled: February 9, 2017Publication date: February 7, 2019Applicant: Japan Science and Technology AgencyInventors: Hideharu MIKAMI, Keisuke GODA
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Patent number: 10018557Abstract: The terahertz wave measuring device includes a pulsed laser light generation unit 1, a seed light generation unit 2, a terahertz wave generator 5 that generates terahertz waves, a terahertz wave detector 8 on which the terahertz waves that are generated from the terahertz wave generator and that have interacted with a measurement object 7 and the pump light are incident and that generates terahertz wave detection light 9, an interference optical system 11 that multiplexes the terahertz wave detection light and reference light 14 of the same wavelength as the terahertz wave detection light to generate a plurality of interfering light beams 12, a plurality of light detectors 13 that detect the interfering light beams, and a signal processing unit 16 that outputs an intensity signal and/or a phase signal of the terahertz waves by performing arithmetic operations on the outputs of the plurality of light detectors.Type: GrantFiled: March 13, 2015Date of Patent: July 10, 2018Assignee: Hitachi High-Technologies CorporationInventors: Nobuhiro Shiramizu, Hideharu Mikami, Koichi Watanabe
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Publication number: 20180106729Abstract: A multiphoton microscope based on two-photon excited fluorescence and second-harmonic generation that images FOVs of about 0.8 mm2 (without stitching adjacent FOVs) at speeds of 10 frames/second (800×800 pixels) with lateral and axial resolutions of 0.5 ?m and 2.5 ?m, respectively. The scan head of the instrument includes a fast galvanometric scanner, relay optics, a beam expander and a high NA objective lens. The system is based on a 25×, 1.05 NA water immersion lens, which features a long working distance of 1 mm. A proper tailoring of the beam expander, which consists of the scan and tube lens elements, enables scaling of the FOV. The system and method also include a flat wavefront of the beam, minimum field curvature, and suppressed spherical aberrations. All aberrations in focus are below the Marechal criterion of 0.07? rms for diffraction-limited performance.Type: ApplicationFiled: October 17, 2017Publication date: April 19, 2018Inventors: Mihaela Balu, Eric O. Potma, Bruce J. Tromberg, Hideharu Mikami
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Publication number: 20180080868Abstract: Provided is a terahertz wave measuring device that can provide means for improving sensitivity, removing unnecessary light, and phase difference detection.Type: ApplicationFiled: March 13, 2015Publication date: March 22, 2018Inventors: Nobuhiro SHIRAMIZU, Hideharu MIKAMI, Koichi WATANABE
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Publication number: 20170307530Abstract: In a multi-color CARS microscope, it has been difficult to accurately bring optical axes of pump light and Stokes light into correspondence and to stably acquire a spectral signal. Accordingly, in an optical analysis device, CARS light is generated from, a sample by using a residual component of the pump light introduced to an optical waveguide and the Stokes light generated in an optical waveguide.Type: ApplicationFiled: October 20, 2014Publication date: October 26, 2017Inventor: Hideharu MIKAMI
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Publication number: 20170160200Abstract: Spectral data such as a CARS spectrum of a sample is acquired at high speed by reducing the amount of data. During scan by emission light focused and emitted onto the sample, the exposed state of a detection unit of a spectroscope that divides light generated from the sample is continued, thereby acquiring spectral data obtained by summing spectra generated at a plurality of positions in the sample.Type: ApplicationFiled: May 26, 2014Publication date: June 8, 2017Applicant: HITACHI, LTD.Inventors: Hideharu MIKAMI, Masataka SHIRAI
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Patent number: 9581497Abstract: A microscope includes: a first light dividing part that divides a light flux of light from a light source into a first pump light flux and a second pump light flux; a Stokes light source that receives the second pump light flux as an input and outputs a Stokes light flux; a multiplexing part that multiplexes the first pump light flux and the Stokes light flux to generate a multiplexed light flux; a first light-collecting part that collects the multiplexed light flux in a sample; a first detector that detects CARS light generated from the sample, the CARS light having a wavelength different from the multiplexed light flux; a second light dividing part that lets at least one of the second pump light flux and the Stokes light flux branch partially as a reference light flux; a second multiplexing part that multiplexes a light flux from the sample and the reference light flux to generate interfering light; and a second detector that detects the interfering light.Type: GrantFiled: October 19, 2012Date of Patent: February 28, 2017Assignee: Hitachi, Ltd.Inventor: Hideharu Mikami
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Publication number: 20150276483Abstract: A microscope includes: a first light dividing part that divides a light flux of light from a light source into a first pump light flux and a second pump light flux; a Stokes light source that receives the second pump light flux as an input and outputs a Stokes light flux; a multiplexing part that multiplexes the first pump light flux and the Stokes light flux to generate a multiplexed light flux; a first light-collecting part that collects the multiplexed light flux in a sample; a first detector that detects CARS light generated from the sample, the CARS light having a wavelength different from the multiplexed light flux; a second light dividing part that lets at least one of the second pump light flux and the Stokes light flux branch partially as a reference light flux; a second multiplexing part that multiplexes a light flux from the sample and the reference light flux to generate interfering light; and a second detector that detects the interfering light.Type: ApplicationFiled: October 19, 2012Publication date: October 1, 2015Inventor: Hideharu Mikami
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Patent number: 9008521Abstract: Provided is an optical receiver including a first delay interferometer, a second delay interferometer, and an input light splitting portion for inputting modulated light. The first delay interferometer includes a first light splitting portion for splitting the input light into first light and second light, a first reflecting portion and a second reflecting portion for causing the first light and the second light to return to the first light splitting portion. The second delay interferometer includes a second light splitting portion for splitting the input light into third light and fourth light, a third reflecting portion and a fourth reflecting portion for causing the third light and the fourth light to return to the second light splitting portion. A region between the first light splitting portion and the second reflecting portion intersects with a region between the second light splitting portion and the fourth reflecting portion.Type: GrantFiled: July 10, 2013Date of Patent: April 14, 2015Assignee: Oclaro Japan, IncInventors: Koki Iemura, Takuma Ban, Hideharu Mikami, Kentaro Osawa
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Patent number: 8891168Abstract: The present invention provides a small and inexpensive optical element that integrates a reflecting mirror and a wave plate function. A reflecting wave plate is configured by arranging a periodic metal comb-like structure whose pitch is equal to or below a wavelength and a mirror structure with a distance equal to or below a coherence length.Type: GrantFiled: October 4, 2010Date of Patent: November 18, 2014Assignee: Hitachi, Ltd.Inventors: Hiroyuki Minemura, Yumiko Anzai, Hideharu Mikami
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Patent number: 8861982Abstract: When designing a demodulator for a DPSK-modulated signal, it is required that optical phase modulation is performed fast and the demodulator has a long lifetime. To achieve this object, a delay line interferometer inside the demodulator performs adjustment of phase difference between two split lights caused to interfere, using a first optical phase modulation unit such as a Piezo actuator and a second optical phase modulation unit such as a heating element that operates slower in modulation speed than the first optical phase modulation unit and is slower in deterioration speed.Type: GrantFiled: January 6, 2011Date of Patent: October 14, 2014Assignee: Oclaro Japan, Inc.Inventors: Hideharu Mikami, Taichi Kogure
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Patent number: 8855502Abstract: In a free space optical system type demodulator of a phase shift keying signal, if a half beam splitter is used as a non-polarizing optical branching unit that is used when generating beams corresponding to I and Q channels or when multiplexing an interference light, control of a power branching ratio is difficult, and it is necessary to suppress phase shifts that are different depending on a polarization state of an input state, and thereby the demodulator becomes high cost. Moreover, since directions of branched lights are different, it is difficult to suppress a skew of the demodulator. In the present invention, the non-polarizing optical branching unit that is used when generating the beams corresponding to the I and Q channels and when multiplexing the interference light is realized using polarization rotating elements and polarization separating elements. Moreover, branched beams are substantially aligned.Type: GrantFiled: July 6, 2011Date of Patent: October 7, 2014Assignee: Oclaro Japan, Inc.Inventor: Hideharu Mikami
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Patent number: 8743370Abstract: A delay interferometer includes a half beam splitter and two pentagonal prisms disposed on a substrate. The half beam splitter branches light to be measured which travels substantially in parallel with the substrate into two branched light beams. The pentagonal prisms respectively reflect the respective branched light beams such that the optical axes of the branched light beams are moved in parallel in a direction substantially perpendicular to the substrate by reflection. The half beam splitter combines the branched light beams reflected by the pentagonal prisms to generate interference light beams.Type: GrantFiled: January 12, 2012Date of Patent: June 3, 2014Assignee: Oclaro Japan, Inc.Inventors: Kentaro Osawa, Hideharu Mikami
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Patent number: 8730775Abstract: Multi-level recording is quite effective for attaining a larger capacity and a higher transfer rate in the case of an optical disk; however, with conventional technologies, a SIGNAL-TO-NOISE RATIO of a signal deteriorates along with an increase in a multi-level degree, creating a factor for limitations to the multi-level degree. In order to solve problems, when optical information is recorded by use of a standing wave occurring due to interference between two light beams, at least one of the two light beams is modulated in multi-stages. Further, at the time of regeneration, a regeneration reference beam is caused to interfere with respective polarization components of a regeneration beam, the polarization components being orthogonal to each other, thereby concurrently generating not less than three interference beams differing in interference phase from each other before being detected.Type: GrantFiled: January 6, 2011Date of Patent: May 20, 2014Assignee: Hitachi Consumer Electronics Co., Ltd.Inventor: Hideharu Mikami
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Patent number: 8699122Abstract: In a delay line interferometer inside a demodulator, with respect to polarization states of two split beams of light to be interfered with each other, p polarization and s polarization are reversed by a half beam splitter and, further, again multiplexed by the half beam splitter used for splitting so that interference beams of light are generated.Type: GrantFiled: June 30, 2010Date of Patent: April 15, 2014Assignee: Oclaro Japan, Inc.Inventor: Hideharu Mikami