Patents by Inventor Hidehiko Kodama

Hidehiko Kodama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CATALYST FOR CONVERTING ESTER TO AMIDE USING HYDROXYL GROUP AS ORIENTATION GROUP
    Publication number: 20210070690
    Abstract: Provided is a method for amidating a hydroxy ester compound at a high chemical selectivity. The amidation reaction method for a hydroxy ester compound comprises, in the presence of a catalyst containing a compound of a transition metal of the group 4 or group 5 in the periodic table, reacting at least one kind of hydroxy ester compound selected from the group consisting of an ?-hydroxy ester compound, a ?-hydroxy ester compound, a ?-hydroxy ester compound and a ?-hydroxy ester compound with an amino compound so as to amidate an ester group having a hydroxyl group at the ?-, ?-, ?- or ?-position of the hydroxy ester compound.
    Type: Application
    Filed: May 22, 2017
    Publication date: March 11, 2021
    Inventors: Hisashi YAMAMOTO, Hiroaki TSUJI, Hidehiko KODAMA, Yoshinori SUZUMA
  • Inhibitor of plasminogen activator inhibitor-1
    Patent number: 8415479
    Abstract: The present invention relates to a novel compound having plasminogen activator inhibitor-1 (PAI-1) inhibitory activity, and a PAI-1 inhibitor comprising the compound as an active ingredient. The present invention further relates to a pharmaceutical composition that has an inhibitory action on PAI-1 activity and is useful in the prevention and treatment of various diseases whose onset is associated with PAI-1 activity. The novel compound is represented by the following general formula. Each symbol is defined as those in the specification.
    Type: Grant
    Filed: March 31, 2009
    Date of Patent: April 9, 2013
    Assignee: Renascience Co., Ltd.
    Inventors: Toshio Miyata, Nagahisa Yamaoka, Hidehiko Kodama, Kenji Murano
  • Plasminogen activator inhibitor-1 inhibitor
    Patent number: 7951806
    Abstract: The present invention relates to an inhibitor of plasminogen activator inhibitor-1. The present invention further relates to a pharmaceutical composition that has an inhibitory action on PAI-1 activity and is useful in the prevention and treatment of various diseases whose onset is associated with PAI-1 activity. Furthermore, the present invention relates to a novel compound having PAI-1 inhibitory activity represented by the following general formula (I), and a salt thereof. Each symbol is defined as those in the specification.
    Type: Grant
    Filed: March 12, 2008
    Date of Patent: May 31, 2011
    Assignee: Renascience Co., Ltd.
    Inventors: Toshio Miyata, Nagahisa Yamaoka, Hidehiko Kodama
  • INHIBITOR OF PLASMINOGEN ACTIVATOR INHIBITOR-1
    Publication number: 20110112140
    Abstract: The present invention relates to a novel compound having plasminogen activator inhibitor-1 (PAI-1) inhibitory activity, and a PAI-1 inhibitor comprising the compound as an active ingredient. The present invention further relates to a pharmaceutical composition that has an inhibitory action on PAI-1 activity and is useful in the prevention and treatment of various diseases whose onset is associated with PAI-1 activity. The novel compound is represented by the following general formula. Each symbol is defined as those in the specification.
    Type: Application
    Filed: March 31, 2009
    Publication date: May 12, 2011
    Applicant: RENASCIENCE CO., LTD.
    Inventors: Toshio Miyata, Nagahisa Yamaoka, Hidehiko Kodama, Kenji Murano
  • PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITOR
    Publication number: 20090124620
    Abstract: The present invention relates to an inhibitor of plasminogen activator inhibitor-1. The present invention further relates to a pharmaceutical composition that has an inhibitory action on PAI-1 activity and is useful in the prevention and treatment of various diseases whose onset is associated with PAI-1 activity. Furthermore, the present invention relates to a novel compound having PAI-1 inhibitory activity represented by the following general formula (I), and a salt thereof. Each symbol is defined as those in the specification.
    Type: Application
    Filed: March 12, 2008
    Publication date: May 14, 2009
    Inventors: Toshio Miyata, Nagahisa Yamaoka, Hidehiko Kodama