Abstract: In an embodiment, an object of the present invention is to provide a double-stranded nucleic acid complex having a novel structure. In an embodiment, the present invention relates to a nucleic acid complex comprising a first nucleic acid strand and a second nucleic acid strand, wherein said first nucleic acid strand: (1) is capable of hybridizing to at least a part of a target transcriptional product; (2) has an antisense effect on the target transcriptional product; and (3) is a gapmer comprising a central region, and a 5? wing region and a 3? wing region, said second nucleic acid strand comprises at least one sugar-unmodified central region (first exposed region) consisting of one sugar-unmodified ribonucleoside or two or three contiguous sugar-unmodified ribonucleosides linked by an internucleoside bond, which is or are complementary to a part of said first nucleic acid strand, and said first nucleic acid strand is annealed to said second nucleic acid strand.

Abstract: A column 2 is provided in a gas capturing unit 20 for capturing sample gas. A gas supply unit 1 supplies carrier gas for sending sample gas into the column 2. A gas separation mechanism 100 guides carrier gas in the column 2 to the outside of the column 2 by setting the lead-out path 5 to negative pressure with respect to the inside of the column 2. A heating unit 23 heats the column 2 to desorb sample gas captured by the gas capturing unit 20. Sample gas desorbed from the gas capturing unit 20 is introduced into a cell 31. A light source unit 32 irradiates sample gas in the cell 31 with light. An analysis unit 3 analyzes sample gas based on an intensity change of light emitted by the light source unit 32.

Abstract: A gas measurement apparatus includes an optical resonator that resonates light, a light source that generates light for irradiation of the optical resonator, and a photodetector that detects light taken out of the optical resonator. The optical resonator includes a plurality of mirrors, a holding member, a hollow tubular member, a hollow tubular member, and a temperature adjustment instrument. The holding member is lower in thermal expansion coefficient than the hollow tubular member. The hollow tubular member includes a portion higher in thermal conductivity than the holding member and a bellows higher in elasticity than a first portion. The hollow tubular member is equal to or higher than the hollow tubular member in thermal conductivity, and is provided as far as positions of the plurality of mirrors on an inner side of the bellows.

Abstract: A light generator including a light source, an optical switch that controls ON/OFF of light from the light source, and a mirror that reflects light from the optical switch and sends the light back to the optical switch. A light generator less in residue in fitting of a ring-down signal, and a radioactive carbon dioxide isotope analysis device and a radioactive carbon dioxide isotope analysis method, by use of the light generator are provided.

Abstract: A carbon isotope analysis method, including the steps of: generating carbon dioxide isotope from carbon isotope; feeding the carbon dioxide isotope into an optical resonator having a pair of mirrors; applying irradiation light having an absorption wavelength of the carbon dioxide isotope into the optical resonator; adjusting a relative positional relationship between the mirrors so that an optical axis of the irradiation light and an optical axis of light generated by the etalon effect are not matched; measuring the intensity of the transmitted light generated by resonance of carbon dioxide isotope excited by the irradiation light; and calculating the concentration of the carbon isotope from the intensity of the transmitted light. An optical resonator that can be suppressed in the parasitic etalon effect, and a carbon isotope analysis device and a carbon isotope analysis method, by use of the optical resonator, are provided.

Abstract: Provided is a carbon isotope analysis device including a carbon dioxide isotope generator provided with a combustion unit that generates gas containing carbon dioxide isotope from carbon isotope, and a carbon dioxide isotope purifying unit; a spectrometer including optical resonators having a pair of mirrors, and a photodetector that determines intensity of light transmitted from the optical resonators; and a light generator including a single light source, a first optical fiber that transmits first light from the light source, a second optical fiber that generates second light of a longer wavelength than the first light, the second optical fiber splitting from the first optical fiber and coupling therewith downstream, a first amplifier on the first optical fiber, a second amplifier on the second optical fiber, different in band from the first amplifier, and a nonlinear optical crystal.

Abstract: A laser device for laser resonance ionization includes a wavelength variable grating-type titanium-doped sapphire laser and includes a titanium (Ti) doped titanium sapphire crystal disposed within a resonator. The titanium sapphire crystal is fixedly disposed on a stage. The titanium-doped sapphire crystal can be moved in the optical axis direction by the stage, thereby changing the position of the titanium-doped sapphire crystal. The switching between the wideband mode and the high-output mode can be performed by changing the position of the titanium-doped sapphire crystal.

Abstract: Provided are a carbon isotope analysis device high in partial pressure of carbon dioxide isotope in gas sent into as optical resonator, and high in sensitivity performance and analytical accuracy, and an analysis method by use of the carbon isotope analysis device. A carbon isotope analysis device including a carbon dioxide isotope generator provided with a combustion unit that generates gas containing carbon dioxide isotope from carbon isotope, and a carbon dioxide isotope purifying unit; a spectrometer including an optical resonator having a pair of mirrors, and a photodetector that determines intensity of light transmitted from the optical resonator; a carbon dioxide trap including a cooler for freezing the carbon dioxide isotope, the carbon dioxide trap being disposed between the carbon dioxide isotope generator and the spectrometer; and a light generator.

Abstract: Provided is a carbon isotope analysis device including a carbon dioxide isotope generator provided with a combustion unit that generates gas containing carbon dioxide isotope from carbon isotope, and a carbon dioxide isotope purifying unit; a spectrometer including optical resonators having a pair of mirrors, and a photodetector that determines intensity of light transmitted from the optical resonators; and a light generator including a single light source, a first optical fiber that transmits first light from the light source, a second optical fiber that generates second light of a longer wavelength than the first light, the second optical fiber splitting from the first optical fiber and coupling therewith downstream, a first amplifier on the first optical fiber, a second amplifier on the second optical fiber, different in band from the first amplifier, and a nonlinear optical crystal.

Abstract: A laser device for laser resonance ionization includes a wavelength variable grating-type titanium-doped sapphire laser and includes a titanium (Ti) doped titanium sapphire crystal disposed within a resonator. The titanium sapphire crystal is fixedly disposed on a stage. The titanium-doped sapphire crystal can be moved in the optical axis direction by the stage, thereby changing the position of the titanium-doped sapphire crystal. The switching between the wideband mode and the high-output mode can be performed by changing the position of the titanium-doped sapphire crystal.

Abstract: A method and apparatus for analyzing carbon isotope 14C is provided. A carbon isotope analyzer including an isotopic carbon dioxide generator to generate isotopic carbon dioxide from a carbon isotope; a spectrometer including an optical resonator having a pair of mirrors, and a photodetector to determine the intensity of light transmitted from the optical resonator; and a light generator including a light source, a first optical fiber to transmit a light beam from the light source, a second optical fiber for wavelength conversion, the second optical fiber branching from the first optical fiber at a point and combining with the first optical fiber at another point downstream of the branching point, and a non-linear optical crystal to generate light having the absorption wavelength of the isotopic carbon dioxide on the basis of the difference in frequency between light beams transmitted through the optical crystal.

Abstract: A carbon isotope analysis device including a carbon dioxide isotope generator provided with a combustion unit that generates gas containing carbon dioxide isotope from carbon isotope, and a carbon dioxide isotope purifying unit; a spectrometer including an optical resonator having a pair of mirrors and a photodetector that determines intensity of light transmitted from the optical resonator; and a light generator including a light source, a splitter that splits light from the light source, a focusing lens that focuses light from the splitter, and a mirror that reflects light from the focusing lens and sends the light back to the light source via the focusing lens and the splitter. A carbon isotope analysis device improved in stability of a light source and a carbon isotope analysis method by use of the analysis device are provided.

Abstract: A carbon isotope analyzer 1 includes a carbon dioxide isotope generator 40 that includes a combustion unit that generates gas containing carbon dioxide isotope from carbon isotope, and a carbon dioxide isotope purifying unit; a spectrometer 10 including an optical resonator 11 having a pair of mirrors 12, and a photodetector 15 that determines the intensity of light transmitted from the optical resonator 11; and a light generator 20 including a light source 23, a first optical fiber 21 to transmit a light beam from the light source 23, a second optical fiber 22 for wavelength conversion, the second optical fiber 22 splitting from the first optical fiber 21 at a point and combining with the first optical fiber 21 at another point downstream of the splitting point, and a non-linear optical crystal 25 that generates light having the absorption wavelength of the carbon dioxide isotope on the basis of the difference in frequency between light beams transmitted through the optical crystal 25.

Abstract: A method and apparatus for analyzing carbon isotope 14C is provided. A carbon isotope analyzer including an isotopic carbon dioxide generator to generate isotopic carbon dioxide from a carbon isotope; a spectrometer including an optical resonator having a pair of mirrors, and a photodetector to determine the intensity of light transmitted from the optical resonator; and a light generator including a light source, a first optical fiber to transmit a light beam from the light source, a second optical fiber for wavelength conversion, the second optical fiber branching from the first optical fiber at a point and combining with the first optical fiber at another point downstream of the branching point, and a non-linear optical crystal to generate light having the absorption wavelength of the isotopic carbon dioxide on the basis of the difference in frequency between light beams transmitted through the optical crystal.

Abstract: A method and apparatus for analyzing carbon isotope 14C is provided. A carbon isotope analyzer including an isotopic carbon dioxide generator to generate isotopic carbon dioxide from a carbon isotope; a spectrometer including an optical resonator having a pair of mirrors, and a photodetector to determine the intensity of light transmitted from the optical resonator; and a light generator including a light source, a first optical fiber to transmit a light beam from the light source, a second optical fiber for wavelength conversion, the second optical fiber branching from the first optical fiber at a point and combining with the first optical fiber at another point downstream of the branching point, and a non-linear optical crystal to generate light having the absorption wavelength of the isotopic carbon dioxide on the basis of the difference in frequency between light beams transmitted through the optical crystal.

Abstract: A carbon isotope analyzer 1 includes a carbon dioxide isotope generator 40 that includes a combustion unit that generates gas containing carbon dioxide isotope from carbon isotope, and a carbon dioxide isotope purifying unit; a spectrometer 10 including an optical resonator 11 having a pair of mirrors 12, and a photodetector 15 that determines the intensity of light transmitted from the optical resonator 11; and a light generator 20 including a light source 23, a first optical fiber 21 to transmit a light beam from the light source 23, a second optical fiber 22 for wavelength conversion, the second optical fiber 22 splitting from the first optical fiber 21 at a point and combining with the first optical fiber 21 at another point downstream of the splitting point, and a non-linear optical crystal 25 that generates light having the absorption wavelength of the carbon dioxide isotope on the basis of the difference in frequency between light beams transmitted through the optical crystal 25.

Abstract: Provided are a simple and convenient apparatus capable of analyzing carbon isotope 14C and a method of analyzing the carbon isotope.