Patents by Inventor Hidemitsu Matsuura

Hidemitsu Matsuura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oncofetal fibronectin epitope
    Patent number: 5300630
    Abstract: An onco-developmentally regulated .alpha.-N-acetylgalactosaminyltransferase isolated as a component of a particulate membrane fraction separated from cell and tissue homogenates and having the following characteristics:(a) Activity in Various Cells and Tissues--present in human fetal lung fibroblasts, hepatoma tissues and placenta, but absent from normal adult liver, lung, kidney and spleen tissues;(b) Substrate Specificity--acts on polypeptides comprising a sequence val-thr-his-pro-gly-tyr by catalyzing u-N-acetylgalactosaminylation at the thr residue of the sequence;(c) Requirements for Metal Ion--requires metal ion for activity in 25 mM tris buffer, pH 7.6;(d) Optimal pH--optimal pH is about 7.6 assayed in hepatoma cell homogenate in tris buffer and at a pH of about 6 to about 7 assayed in hepatoma cell homogenate enzyme activity is higher in 2(N-morpholino)ethanesulfonic acid than in cacodylate buffer; and(e) Km--apparent Km for UDP - GalNAc is about 48 .mu.M.
    Type: Grant
    Filed: October 2, 1992
    Date of Patent: April 5, 1994
    Assignees: Fred Hutchinson Cancer Research Institute, The Biomembrane Institute, The Board of Regents of the University of Washington
    Inventors: Hidemitsu Matsuura, Sen-itiroh Hakomori, Koiti Titani
  • Oncofetal structure of fibronectin
    Patent number: 5243029
    Abstract: Antibody defining structure present in fibronectins from tumors and fetal tissues but absent in fibronectins from normal adult tissues and plasma; useful for diagnosing and treating human cancers.
    Type: Grant
    Filed: November 4, 1991
    Date of Patent: September 7, 1993
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: Hidemitsu Matsuura, Sen-Itiroh Hakomori
  • Onco-developmentally regulated .alpha.-N-acetylgalactosaminyltransferase
    Patent number: 5177015
    Abstract: An onco-developmentally regulated .alpha.-N-acetylgalactosaminyltransferase is isolated as a component of a particulate membrane fraction separated from cell and tissue homogenates which has the following characeristics:(a) Activity in Various Cells and Tissues--present in human fetal lung fibroblasts, hepatoma tissues and placenta, but absent from normal adult liver, lung, kidney and spleen tissues;(b) Substrate Specificity--acts on polypeptides comprising a sequence of val-thr-his-pro-gly-tyr by catalyzing .alpha.-N-acetylgalactosaminylation at the thr residue of the sequence;(c) Requirements for Metal Ion--requires metal ion for activity in 25 mM tris buffer, pH 7.6;(d) Optimal pH--optimal pH is about 7.6 asssayed in hepatoma cell homogenate in tris buffer and at a pH of about 6 to about 7 assayed in hepatoma cell homogenate enzyme activity is higher in 2(N-morpholino)ethanelsulfonic acid than in cacodylate buffer; and(e) Km--apparent Km for UDP - GalNAc is about 48 .mu.m.
    Type: Grant
    Filed: January 22, 1992
    Date of Patent: January 5, 1993
    Assignee: Fred Hutchinson Cancer Research Centre
    Inventors: Hidemitsu Matsuura, Sen-itiroh Hakomori
  • Monoclonal antibody defining oncofetal structure of fibronectin
    Patent number: 4894326
    Abstract: Antibody defining structure present in fibronectins from tumors and fetal tissues but absent in fibronectins from normal adult tissues and plasma; useful for diagnosing and treating human cancers.
    Type: Grant
    Filed: April 9, 1986
    Date of Patent: January 16, 1990
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: Hidemitsu Matsuura, Sen-itiroh Hakomori