Patents by Inventor Hidenori Kimura
Hidenori Kimura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11911466Abstract: The present invention provides a compound of the formula (1): wherein X, R1, R2, R3, R4, R5, R6, Y1, Y2, L, and m are as defined in the description, and a pharmaceutically acceptable salt thereof, which are useful as a vaccine adjuvant.Type: GrantFiled: January 25, 2022Date of Patent: February 27, 2024Assignee: Sumitomo Pharma Co., Ltd.Inventors: Hidenori Kimura, Hitoshi Ban, Yoshiaki Isobe, Hitoshi Watanabe
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Patent number: 11731960Abstract: The present invention provides a compound of formula (1) and a pharmaceutical composition comprising the compound useful as a nerve regeneration promoter wherein R1-L- is R1—OC(O)—, or the like, R1 is hydrogen atom, optionally-substituted C1-6 alkyl group, optionally-substituted 3- to 8-membered cycloalkyl group, or the like, R2 is hydrogen atom or the like, Ring A is formula (2) or formula (3) wherein R3 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like, the part of X, Y, and Z is X?Y—Z, X—Y?Z, or X—Y—Z, X is nitrogen atom, NR4 (R4 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like), or the like, Y is carbon atom or the like, and Z is carbon atom, nitrogen atom or the like.Type: GrantFiled: July 22, 2022Date of Patent: August 22, 2023Assignee: SUMITOMO PHARMA CO., LTD.Inventors: Hitoshi Watanabe, Yoshiaki Isobe, Hidenori Kimura, Yuji Fujiwara
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Publication number: 20220380353Abstract: The present invention provides a compound of formula (1) and a pharmaceutical composition comprising the compound useful as a nerve regeneration promoter wherein R1-L- is R1—OC(O)—, or the like, R1 is hydrogen atom, optionally-substituted C1-6 alkyl group, optionally-substituted 3- to 8-membered cycloalkyl group, or the like, R2 is hydrogen atom or the like, Ring A is formula (2) or formula (3) wherein R3 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like, the part of X, Y, and Z is X=Y-Z, X-Y=Z, or X-Y-Z, X is nitrogen atom, NR4 (R4 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like), or the like, Y is carbon atom or the like, and Z is carbon atom, nitrogen atom or the like.Type: ApplicationFiled: July 22, 2022Publication date: December 1, 2022Applicant: SUMITOMO PHARMA CO., LTD.Inventors: Hitoshi WATANABE, Yoshiaki ISOBE, Hidenori KIMURA, Yuji FUJIWARA
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Patent number: 11440905Abstract: The present invention provides a compound of formula (1) and a pharmaceutical composition comprising the compound useful as a nerve regeneration promoter wherein R1-L- is R1—OC(O)—, or the like, R1 is hydrogen atom, optionally-substituted C1-6 alkyl group, optionally-substituted 3- to 8-membered cycloalkyl group, or the like, R2 is hydrogen atom or the like, Ring A is formula (2) or formula (3) wherein R3 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like, the part of X, Y, and Z is X?Y—Z, X—Y?Z, or X—Y—Z, X is nitrogen atom, NR4 (R4 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like), or the like, Y is carbon atom or the like, and Z is carbon atom, nitrogen atom or the like.Type: GrantFiled: October 26, 2020Date of Patent: September 13, 2022Assignee: SUMITOMO PHARMA CO., LTD.Inventors: Hitoshi Watanabe, Yoshiaki Isobe, Hidenori Kimura, Yuji Fujiwara
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Publication number: 20220226468Abstract: The present invention provides a compound of the formula (1): wherein X, R1, R2, R3, R4, R5, R6, Y1, Y2, L, and m are as defined in the description, and a pharmaceutically acceptable salt thereof, which are useful as a vaccine adjuvant.Type: ApplicationFiled: January 25, 2022Publication date: July 21, 2022Inventors: Hidenori Kimura, Hitoshi Ban, Yoshiaki Isobe, Hitoshi Watanabe
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Patent number: 11266738Abstract: The present invention provides a compound of the formula (2): wherein X, R1, R2, R3, R4, R5, R6, R8, Y1, Y2, and L are as defined in the description, and a pharmaceutically acceptable salt thereof, which are useful as a vaccine adjuvant.Type: GrantFiled: March 18, 2020Date of Patent: March 8, 2022Assignee: Sumitomo Dainippon Pharma Co., Ltd.Inventors: Hidenori Kimura, Hitoshi Ban, Yoshiaki Isobe, Hitoshi Watanabe
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Publication number: 20210198242Abstract: The present invention provides a compound of formula (1) and a pharmaceutical composition comprising the compound useful as a nerve regeneration promoter wherein R1-L- is R1—OC(O)—, or the like, R1 is hydrogen atom, optionally-substituted C1-6 alkyl group, optionally-substituted 3- to 8-membered cycloalkyl group, or the like, R2 is hydrogen atom or the like, Ring A is formula (2) or formula (3) wherein R3 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like, the part of X, Y, and Z is X?Y—Z, X—Y?Z, or X—Y—Z, X is nitrogen atom, NR4 (R4 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like), or the like, Y is carbon atom or the like, and Z is carbon atom, nitrogen atom or the like.Type: ApplicationFiled: October 26, 2020Publication date: July 1, 2021Applicant: SUMITOMO DAINIPPON PHARMA CO., LTD.Inventors: Hitoshi Watanabe, Yoshiaki Isobe, Hidenori Kimura, Yuji Fujiwara
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Publication number: 20210008197Abstract: The present invention provides a compound of the formula (1): wherein X, R1, R2, R3, R4, R5, R6, Y1, Y2, L, and m are as defined in the description, and a pharmaceutically acceptable salt thereof, which are useful as a vaccine adjuvant.Type: ApplicationFiled: March 18, 2020Publication date: January 14, 2021Applicant: Sumitomo Dainippon Pharma Co., Ltd.Inventors: Hidenori Kimura, Hitoshi Ban, Yoshiaki Isobe, Hitoshi Watanabe
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Patent number: 10870642Abstract: The present invention provides a compound of formula (1) and a pharmaceutical composition comprising the compound useful as a nerve regeneration promoter wherein R1-L- is R1—OC(O)—, or the like, R1 is hydrogen atom, optionally-substituted C1-6 alkyl group, optionally-substituted 3- to 8-membered cycloalkyl group, or the like, R2 is hydrogen atom or the like, Ring A is formula (2) or formula (3) wherein R3 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like, the part of X, Y, and Z is X?Y—Z, X—Y?Z, or X—Y—Z, X is nitrogen atom, NR4 (R4 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like), or the like, Y is carbon atom or the like, and Z is carbon atom, nitrogen atom or the like.Type: GrantFiled: April 24, 2019Date of Patent: December 22, 2020Assignee: SUMITOMO DAINIPPON PHARMA CO., LTD.Inventors: Hitoshi Watanabe, Yoshiaki Isobe, Hidenori Kimura, Yuji Fujiwara
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Patent number: 10632192Abstract: The present invention provides a compound of the formula (1): wherein X, R1, R2, R3, R4, R5, R6, Y1, Y2, L, and m are as defined in the description, and a pharmaceutically acceptable salt thereof, which are useful as a vaccine adjuvant.Type: GrantFiled: October 6, 2016Date of Patent: April 28, 2020Assignee: Sumitomo Dainippon Pharma Co., Ltd.Inventors: Hidenori Kimura, Hitoshi Ban, Yoshiaki Isobe, Hitoshi Watanabe
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Publication number: 20190308958Abstract: The present invention provides a compound of formula (1) and a pharmaceutical composition comprising the compound useful as a nerve regeneration promoter wherein R1-L- is R1—OC(O)—, or the like, R1 is hydrogen atom, optionally-substituted C1-6 alkyl group, optionally-substituted 3- to 8-membered cycloalkyl group, or the like, R2 is hydrogen atom or the like, Ring A is formula (2) or formula (3) wherein R3 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like, the part of X, Y, and Z is X?Y—Z, X—Y?Z, or X—Y—Z, X is nitrogen atom, NR4 (R4 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like), or the like, Y is carbon atom or the like, and Z is carbon atom, nitrogen atom or the like.Type: ApplicationFiled: April 24, 2019Publication date: October 10, 2019Applicant: Sumitomo Dainippon Pharma Co., Ltd.Inventors: Hitoshi Watanabe, Yoshiaki Isobe, Hidenori Kimura, Yuji Fujiwara
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Patent number: 10323024Abstract: The present invention provides a compound of formula (1) and a pharmaceutical composition comprising the compound useful as a nerve regeneration promoter wherein R1-L- is R1—OC(O)—, or the like, R1 is hydrogen atom, optionally-substituted C1-6 alkyl group, optionally-substituted 3- to 8-membered cycloalkyl group, or the like, R2 is hydrogen atom or the like, Ring A is formula (2) or formula (3) wherein R3 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like, the part of X, Y, and Z is X?Y—Z, X—Y?Z, or X—Y—Z, X is nitrogen atom, NR4 (R4 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like), or the like, Y is carbon atom or the like, and Z is carbon atom, nitrogen atom or the like.Type: GrantFiled: January 12, 2017Date of Patent: June 18, 2019Assignee: SUMITOMO DAINIPPON PHARMA CO., LTD.Inventors: Hitoshi Watanabe, Yoshiaki Isobe, Hidenori Kimura, Yuji Fujiwara
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Publication number: 20190016711Abstract: The present invention provides a compound of formula (1) and a pharmaceutical composition comprising the compound useful as a nerve regeneration promoter wherein R1-L- is R1—OC(O)—, or the like, R1 is hydrogen atom, optionally-substituted C1-6 alkyl group, optionally-substituted 3- to 8-membered cycloalkyl group, or the like, R2 is hydrogen atom or the like, Ring A is formula (2) or formula (3) wherein R3 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like, the part of X, Y, and Z is X?Y—Z, X—Y?Z, or X—Y—Z, X is nitrogen atom, NR4 (R4 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like), or the like, Y is carbon atom or the like, and Z is carbon atom, nitrogen atom or the like.Type: ApplicationFiled: January 12, 2017Publication date: January 17, 2019Applicant: SUMITOMO DAINIPPON PHARMA CO., LTD.Inventors: Hitoshi WATANABE, Yoshiaki ISOBE, Hidenori KIMURA, Yuji FUJIWARA
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Publication number: 20180280499Abstract: The present invention provides a compound of the formula (1): wherein X, R1, R2, R3, R4, R5, R6, Y1, Y2, L, and m are as defined in the description, and a pharmaceutically acceptable salt thereof, which are useful as a vaccine adjuvant.Type: ApplicationFiled: October 6, 2016Publication date: October 4, 2018Inventors: Hidenori Kimura, Hitoshi Ban, Yoshiaki Isobe, Hitoshi Watanabe
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Patent number: 9758480Abstract: A compound represented by formula (1) (in the formula: ring-D represents a three- to eight-membered hydrocarbon ring; Ra represents an optionally substituted amino C1-6 alkyl group or the like; Rb1 and Rb2 each independently represent a hydrogen atom, a halogen atom, or the like; Rc represents an optionally substituted C6-10 aryl group or the like; Rd represents a hydrogen atom or the like; and ring-Q represents a (hetero)aryl group or the like which may be substituted with a carboxyl group or the like) or a pharmaceutically acceptable salt thereof exhibits an excellent FXIa inhibitory activity, and is useful as a therapeutic agent against thrombosis or the like.Type: GrantFiled: July 18, 2013Date of Patent: September 12, 2017Assignee: SUMITOMO DAINIPPON PHARMA CO., LTD.Inventors: Yohei Ikuma, Nobuhisa Fukuda, Masato Iwata, Hidenori Kimura, Kuniko Suzuki
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Patent number: 9216132Abstract: A device that supports a motion for restoring an inclination angle of a body to a reference direction is provided. A balance device includes a sensor, at least one flywheel, and a controller. The sensor is configured to detect an inclination angle of the body with respect to the reference direction. The at least one flywheel is arranged on the balance device so that an axis of the flywheel is non-parallel to a yaw axis of the body when the balance device is attached to a user. The yaw axis of the body corresponds to a longitudinal direction of the body. In addition, the yaw axis coincides with the reference direction when the user stands erect. The controller is configured to change a rotation rate of the flywheel based on an inclination angle detected by the sensor.Type: GrantFiled: September 22, 2010Date of Patent: December 22, 2015Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHAInventors: Eisuke Aoki, Hitoshi Konosu, Hidenori Kimura, Tytus Wojtara, Shingo Shimoda
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Publication number: 20150210640Abstract: A compound represented by formula (1) (in the formula: ring-D represents a three- to eight-membered hydrocarbon ring; Ra represents an optionally substituted amino C1-6 alkyl group or the like; Rb1 and Rb2 each independently represent a hydrogen atom, a halogen atom, or the like; Rc represents an optionally substituted C6-10 aryl group or the like; Rd represents a hydrogen atom or the like; and ring-Q represents a (hetero)aryl group or the like which may be substituted with a carboxyl group or the like) or a pharmaceutically acceptable salt thereof exhibits an excellent FXIa inhibitory activity, and is useful as a therapeutic agent against thrombosis or the like.Type: ApplicationFiled: July 18, 2013Publication date: July 30, 2015Applicant: SUMITOMO DAINIPPON PHARMA CO., LTD.Inventors: Yohei Ikuma, Nobuhisa Fukuda, Masato Iwata, Hidenori Kimura, Kuniko Suzuki
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Patent number: 8620844Abstract: Using variable neuron thresholds and extended Hebb's rule in a neural network, a neuron device for simulating a nerve cell includes a threshold storage unit storing a threshold variable ? and threshold coefficients ??1 and ??2; an input reception unit receiving one or more input signal values at predetermined time intervals; an output unit outputting an output signal value “1” indicating that the neuron device is firing when the sum total s of received input signal values is equal to or greater than the value of the stored threshold variable ?, or a value “0” indicating that the neuron device is resting; and a threshold updating unit calculating ??1X+??2(X?1) using the output signal value X and the stored threshold coefficients ??1 and ??2 and updating the value of the threshold variable ? stored in the threshold storage unit by increasing it by the calculation result.Type: GrantFiled: September 30, 2008Date of Patent: December 31, 2013Assignees: Riken, Toyota Jidosha Kabushiki KaishaInventors: Shingo Shimoda, Hidenori Kimura, Masaaki Yamaoka, Hideki Kajima
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Patent number: 8389511Abstract: The present invention relates to a compound of the following formula (I) or a pharmaceutically acceptable salt thereof, being useful as a renin inhibitor. [wherein R1a is halogen, etc.; R1m is H, etc.; G1 is —N(R1b)—, etc.; G2 is —CO—, etc.; G3 is —C(R1c)(R1d)—, etc.; G4 is oxygen, etc.; R1b is optionally substituted C1-6 alkyl, etc.; R1c and R1d are independently the same or different, H, etc.; R3 is H, optionally substituted C1-6 alkyl, etc.; R3a, R3b, R3c and R3d are independently the same or different, and a group: -A-B (said A is single bond, etc., and said B is H, etc.), etc.; and n is 1, etc.Type: GrantFiled: December 19, 2008Date of Patent: March 5, 2013Assignee: Dainippon Sumitomo Pharma Co., Ltd.Inventors: Hiroyuki Nakahira, Yohei Ikuma, Nobuhisa Fukuda, Kozo Yoshida, Hidenori Kimura, Satoshi Suetsugu, Akira Fusano, Kiyoto Sawamura, Junya Ikeda, Yoshio Nakai
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Publication number: 20120253247Abstract: A device that supports a motion for restoring an inclination angle of a body to a reference direction is provided. A balance device comprises a sensor, at least one flywheel, and a controller. The sensor is configured to detect an inclination angle of the body with respect to the reference direction. The at least one flywheel is arranged on the balance device so that an axis of the flywheel is non-parallel to a yaw axis of the body when the balance device is attached to a user. The yaw axis of the body corresponds to a longitudinal direction of the body. In addition, the yaw axis coincides with the reference direction when the user stands erect. The controller is configured to change a rotation rate of the flywheel based on an inclination angle detected by the sensor.Type: ApplicationFiled: September 22, 2010Publication date: October 4, 2012Applicant: TOYOTA JIDOSHA KABUSHIKI KAIHSAInventors: Eisuke Aoki, Hitoshi Konosu, Hidenori Kimura, Tytus Wojtara, Shingo Shimoda